The changes of platelet counts and serum TPO levels in chronic hepatitis C patients during consensus interferon therapy are reversible. Multivariate logistic regression analysis showed that an age of less than 45 years and a serum TPO level elevation greater than 50% of baseline level at week 12 of consensus interferon treatment are significant independent predictors associated with the sustained response to treatment (75 chronic hepatitis C patients) [51]. To complement thrombocyte counts, the prothrombin time and ALT/AST ratio, Saaden et al. have introduced a number of additional parameters, the most informative of which turned out to be the age, the level of g-glutamyl transferase GGT and the quantity of blood serum albumin (BSA). Clinical and laboratory analysis enabled a noninvasive diagnosis of liver cirrhosis for a considerable number of patients [19]. According to this extended Bonancini scale, the average evaluation score for the patients with histologically confirmed cirrhosis was 5.5±1.9, and for non-cirrhotic patients, 3.5±1.5. None of non-cirrhotic hepatitis C patients had the score over 7. Totally, in 30% of cases one can avoid the biopsy and with a high probability either reject or formulate liver cirrhosis by non-invasive biochemical scoring [19].