The most frequent complications were vaso-vagal episodes with four collapses that required atropine treatment. The live threatening complications included hemoperitoneum, biliary peritonitis, and pneumothorax puncture some due to blind biopsy without ultrasonic monitoring [33]. The complication rate increased with inceased number of needle passes that were necessitated by the failure to obtain a material fit for examination (26.6% of the complications occurred with one manipulation and 68% with two and more manipulations) [33]. Special concerns on the probability of serious complications arise when more then two needle manipulations in liver tissue are required [36]. If liver biopsy is performed under the ultrasonic monitoring, atropine premedication, and if the preliminary examination is made to eliminate the risk of hemorrhage due to hypocoagulation, the number of complications related to this procedure decreases drastically. The later study of liver biopsy in a smaller group group of HCV patients (n=122) reveal no major complications [19]. Minor complications such as pains that did not require drug intervention were recorded in 9.5%; the pains that did require drug intervention, in 15.1% and emergency treatment, in 3.2% of cases. The lack of serious complications in this study may have been related to the fact all biopsies were carried out in one center in compliance with standard rules, but also, to the fact that the group of patients was relatively small.