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Unfortunately, the situation in this sphere of research is rather complicated. The scale we have developed corresponds to the WHO protocol only partly since at present there exists only the Russian version that, hence, does not meet the requirements of transcultural appropriateness, the unique requirement of the WHO project. The scale can receive a WHO Instrument status only after being modified through international collaboration with a sufficient number of other countries. The participation of the Bekhterev Institute in the development of the WHOQOL-100 has also given a stimulus to the translation, adaptation and approbation of the Lancashire Quality of Life Profile (LQOLP) for the mentally ill. At present a comparison of the WHOQOL-100, SM-QOL and LQOLP on a Russian sample of mental patients is being carried out. We are also developing an original universal quality of life scale QOL-SD (Quality of Life – Semantic Differential) claiming to be able to measure specific effects of psychosocial work with various types of psychoneurological patients and their family members.