Thus leishmaniasis is linked to poverty, economic development and environmental changes such as deforestation, urbanization, migration of people into endemic areas and the building of dams, etc. The annual incidence rate is estimated to be 1-1.5 million cases of cutaneous leishmaniasis and half a millon cases of visceral leishmaniasis occur each year according the World Health Organization (WHO). 90% of all visceral leishmaniasis cases occur in Bangladesh, Brazil, India, especially in the state of Bihar and in the Sudan. 90% of mucocutaneous leishmaniasis occurs in Bolivia, Brazil and Peru. 90% of cutaneous leishmaniasis cases occur in Afghanistan, Brazil, Iran, Peru, Saudi Arabia and Syria.