In collaboration with Joe Blondeau we also measured MPC for about 150 clinical isolates of S. pneumoniae to compare fluoroquinolones. Since activity measurements are meaningless without consideration of pharmacokinetics, we show MPC relative to drug concentrations achieved with standard doses. What you see is that moxifloxacin is above its MPC for roughly half a day while levofloxacin, at the standard 500 mg dose, never reaches MPC. Thus we would predict that moxifloxacin would be more effective than levofloxacin at restricting the development of resistance.