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picture |
As a test of the window idea
Alex Firsov and Steve Zinner (12) carried out a pharmacodynamic study in which
moxifloxacin concentration was varied so that it was either above, within, or below the
selection window throughout treatment using an in vitro model (left panels). The
dynamic model contained Staphylococcus aureus, and at the times indicated by the
arrows moxifloxacin was added and samples were taken for analysis. Determination of MIC
showed that resistant mutants were enriched only when the moxifloxacin concentration was
inside the selection window for at least 20% of the time. |
