prev next front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |29 |30 |31 |32 |review
African American women may be particularly vulnerable to CHD as a result of diabetes, not only because of their increased prevalence relative to other race/gender mixes but also because of the cumulative effects of hypertension, glucose intolerance and dyslipedemia, commonly known as syndrome x (18). Persons with diabetes are also more likely to have hypertension and dyslipidemia, both of which are associated with a higher cardiovascular mortality. This syndrome has a synergistic effect on atherogenesis and is typically seen more often in blacks, particularly black women (18). Diabetes has also been implicated as a possible etiology of the increased incidence of CHD in young black women. Animal studies have suggested that hyperglycemia and hyperinsulinemia-insulin resistence prevent the cardiovascular protective effects of estrogen. Because black women have a higher incidence of both diabetes and obesity relative to white women, this mechanism may eliminate the protection from CHD that female sex normally provides (19).