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Knowing the mechanisms of the famous interactions, it isnít that difficult to predict how medications are going to interact. Phenytoin has potent metabolic consequences for many medications. The same is true for cimetidine. Note the number of empty boxes, and the number of question marks; the question marks represent either single case reports or an apparent interaction the mechanism of which cannot be established. Also, having filled in as many of the known or even possible drug interactions, there are still many question marks, and many blanks!