||This is a simplification of a
lot of tabulated data of the pain score and the disappearance of pain for all four limbs
over time. Now, if youíre going to inject this capsaicin and youíre going to have
pain, but if you proceeded it by a placebo cream instead of an anesthetic cream, what will
happen? The person will expect that there will be perhaps an attenuation of the pain in
that limb, or if itís in the leg, in the other limb.
What really happens is that the pain diminished and went away more
quickly in the very limbs that had the placebo cream applied but not the other limbs. And
if before the cream, and before the skin injection, you got a shot of placebo, it didnít
affect it, but if you got a shot of Naloxone, what happened is that relief of pain
completely disappeared. It works through opiates and itís spatially specific.