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DiPaola and his colleagues at Rutgers a couple of years ago showed that at least part of the activity of PC SPES is because in the herbs are botanical equivalents of animal estrogens, and at least some of this is due to estrogenic activity, as evidenced by the fact that most of the men on this have a decrease in libido, have breast tenderness, enlargement and other estrogenic type responses.

Adrian Dobs and her colleagues at Johns Hopkins University through peer review was funded to do the first placebo control trial of this herbal remedy. This is in 100 men with hormone refractory disease, comparing it to a standard estrogenic treatment, estradiol. She’s doing this in Baltimore and in Singapore, and measuring the kinds of things one would need to show that a prostate cancer drug is effective.