Numerous SBS risk factors have been identified. While the primary risk factor is poor indoor air quality, human and psychological factors also affect the occurrence of symptoms.

Building characteristics: mechanical ventilation with air conditioning, new or renovated buildings, wall to wall carpet, water damage.

Indoor environments: low ventilation, low humidity, high temperature, chemicals (volatile organic compounds, environmental tobacco smoke, perfume).

Work conditions: video display terminal, photocopying machine, overtime.

Human factors: female gender, younger age, history of allergy.

Psychological factors: work overload, control of work, co-worker support.