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Human Epidemiological Studies
-Advantages
Relevant species (no extrapolation)
Relevant exposures (no extrapolation) 
-Disadvantages
Insensitive
Long latency
Confounding
Complex exposures
No experimental data

Laboratory Animal Toxicological Studies
-Advantages
Homogeneous population
Controlled conditions & exposures
Short time 
-Disadvantages
Homogeneous population
High to low dose extrapolation
Animal welfare issues