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We define the "case component" as hazard period which is the time period right before the disease or event onset; and the "control component" as control period which is a specified time interval other than the hazard period. The information of the individual "exposed to certain activity or agent during the hazard period and control period will be compared. If we collect such information from many subjects who had the disease or event, we can test for consistent relationships between the disease and the exposure.