prev next front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |review
Congenital hypothyroidism

A serious mentally disabling disease of

extreme public health significance.

thro3.jpg (7845 bytes)

(look at the web source of the image)

Observations of the patients with congenital hypothyroidism (CH) are consistent with point mutations and autosoaml-recessive inheritance for the full defect. Consanguinity has been the rule. The most serious outcome of congenital hypothyroidism is mental retardation. Most common causes include aplasia and hypoplasia, radioiodine, Iodine deficiency, thyrotropin deficiency, thyroid hormone unresponsiveness and defective synthesis of thyroxine.

Though recent studies reported the possibility of a prenatal diagnosis, neonatal screening is the most useful and practical tool for early diagnosis and treatment of congenital hypothyroidism..