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Using Cox Proportional Hazards modeling for CHD (defined as myocardial infarction, CHD death, or angina diagnosed by an EDC physician), duration and hypertension were found to be strong predictors. There are also two gender risk factor interactions. One is related to physical activity (number of flights of stairs climbed per day), suggesting that increased physical activity in women was protective. The other gender interaction is depressive symptomatology which also increased risk in women in this analysis. Waist hip ratio, an indirect measure of visceral adiposity and thereby insulin resistance, was also an independent predictor. Subsequent analyses with follow-up up to 8 years have suggested that depressive symptomatology also predicts in men as well as women.