Transferrin is the major protein responsible for transporting Iron
in the body. Most of Iron in the mucosal cell is transferred to the
blood almost immediately after absorption, binded to transferrin.
After it rapid phase, transfer continuous at a slower rate during 24 hours.
Transferrin is synthesized in the liver and secondarily in the female breast.
Transferrin receptors, located on the surface of nearly all cells in the body,
can bind two molecules of transferrin. There is an up regulation mechanism of
transferrin receptors synthesis, what allows the cell to increase the cellular
uptake under Iron deficiency conditions. Both transferrin concentration and
transferrin receptors are important in assessing ID