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In summary, there is a hierarchy of studies from ones that open up a question to ones that may be the definitive answer, or as close to that as is possible. With increasing certainty comes increasing complexity and attention to detail (and increasing expense, time, and cooperation). Epidemiology is now a large industry, worldwide, and the successes since World War II have been very substantial. For more information on these topics, there are two best-seller text books available on the web:

 

Epidemiology for the uninitiated

 

Statistics at Square one