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There are many RCTs being conducted all over the world—supposedly 7,000 at any one time. One reason for this is that they are often studies that take many years before a clear picture of the outcomes in the two groups can be determined. Also, since these studies are the end of the line in study design, the answers need to be as unequivocal as possible, and so collaboration by many centers around the world is common. Nevertheless, the studies are often repeated to be sure that one treatment is better than another, or changed a little with different dosages of drugs or other comparisons, especially as new treatments keep on appearing and offering to improve on the current best ones.