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In summary, the development of Type 2 diabetes is characterized 1) by
development of insulin resistance, followed by 2) impaired glucose
tolerance, and 3)insulin secretory failure.
Thus Type 2 diabetes is characterised by the presence of hyperglycemia accompanied by insulin resistance and defects in insulin secretion. The other characteristic metabolic abnormality, increased hepatic glucose output, occurs as a result of insulin deficiency. |