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Two other mechanisms have been suggested for beta-cell failure. When the capacity of beta-cells to produce the insulin becomes maximized and the need for insulin continues to increase, the demand may simply exceed the capacity. If so hyperglycemia will worsen. Furthermore, experimental studies have shown that exposure of beta-cells to hyperglycemia per se will downregulate the glucose sensing mechanisms of the beta cells. Thus an alternative mechanism explaining why beta-cell failure may occur is that it is a result of desensitization due to to glycemia (Glucotoxicity hypothesis).