- Typical neuropathological findings in methylmercury
poisoning were first described by Hunter-Russell (1954). Minamata disease exhibits a
variety of neuropathological features, from severe changes at the early stage to mild
- The pronounced changes in the white matter in the brains
were usually unobservable in the first three years following poisoning but emerged (4-6
years) and became widespread after 10 years.
- Preferential, localized neuropatho-logic disintegration in
the brain occurred mainly in the calcarine contex, precentral and postcentral cortices and
central portion of the cerebellum in typical cases.
- The changes were characterised by tissues coarseness,
sclerosis was observed in some cases, and the later stages were characterised by thinning
of the myelim.