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Relation between CHD in type 2 diabetes and
apolipoprotein B gen polymorphhism
Conclusion
In China, now the work have been developed to research the relationship
between lipid problems and non-insulin dependent diabetes mellitus(NIDDM), in
following two aspects: 1)comparison of BMI and serum lipids between patient
with NIDDM and normal control group (see attached table ); 2) genetic analysis
for lipid genotype related to NIDDM. The later work included polymorphic
analysis of allele frequencies of CETP, apoE, Lp(a), apo B(EcoRI and XbaI)
and lipoprotein lipase(HindIII) genes, but only few there were some differences
of the allele frequencies between NIDDM and control groups
(Table). The serum results
showed that NIDDM may induce some complications associated closely with
lipoprotein metabolism disorders, such as arteriosclerosis, coronary
arteriosclerosis diseases and hypertension.
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