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Methylmercury enters the food chain by rapid diffusion and tight binding to proteins. As a result of food-chain biomagnification, highest levels are found in the tissues of such predatory species as freshwater trout, pike and ocean tuna, swordfish, and shark.

The bioconcentration factor (CF), i.e., the ratio of the concentration of methylmercury in fish tissue to that in water, is usually between 1,000 and 10,000.