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  • Genital ulcers (macro or microscropic) are a privileged entry point for HIV. Local inflammatory reaction drains in defense cells which, at the same time, serve as host cells for the virus.
  • Many factors explain the STD outbreak: social changes, promiscuity in wildly expanding towns, migrations, insufficient health services
  • the role of high risk groups for STD transmission is known since the early 1970s