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Following published scientific evidences, several governments produced
official recommendations, which, with minor variations, include
the supplementation of 0.4 mg of folic acid daily,
from one month before to two months after conception, that is,
PERICONCEPTIONALLY But, There is no sense in providing just one single vitamin
to undernourished poor populations.
Czeizel AE, Dudás I (1992) Prevention of the first occurrence of neural-tube
defects by periconceptional vitamin supplementation. N Engl J Med, 327:
1832-1835.
MRC Vitamin Study Research Group (1991): Prevention of neural tube defects:
results of the Medical Resarch Council Vitamin Study. Lancet 338:131-137.
Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, Rozen R,
Oakley GP, Adams MJ. (1996). 5,10 methylenetetrahydrofolate reductase genetic
polymorphism as a risk factor for neural tube defects. Am J Med Genet
63:610-614.
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