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Primary preventive measures have to be taken first because they are cheaper and more effective. They act on risk factors, which are numerous and entangled. In developed populations, many risk factors were automatically controlled by the same process of social, educational, and economical development. i.e.: Extreme maternal ages were reduced by family planning. Maternal illnesses were reduced by effective immunologic protection of the whole population and other actions of health promotion. Drug sales were controlled by reinforced rules as well as by public education.