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The three major classes of external carcinogens, and perhaps to some extent diet (although how it plays its role is not yet understood), exert their effect through multiple steps involving a final common pathway - the oncogenes.
The final result is malignant transformation and then the development through further genomic
instability the properties of invasiveness and metastasis.
 

 

 

 

 

 

Malignant Transformation   

 

 

 

 

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