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The results of our analysis of the molecular epidemology of type 1 diabetes were obtained by the relative risk estimates from the case-control analysis to the established incidence rate for type 1 diabetes for Allegheny Country, PA. Therefor, by linking descriptive and analytical molecular epidemiology studies, we can: 1) estimate individuals’ relative risk of disease (i.e., magnitude of the increase in risk associated with the presence of a specific molecular marker), and also 2) determine their absolute risk of disease (i.e., probability of developing the disease) if the molecular markers under evaluation are present. Information regarding absolute risk of disease is essential for the development of medical and public health strategies for disease prevention. However, these estimates require knowledge of the general epidemiology of the disease in the population under investigation, particularly incidence/prevalence rates.

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