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Molecular epidemiology is one of the most exciting and important areas of research leading into the 21st century. It represents a critical link between the Human Genome Project and medicine/public health. Without well-designed population-based molecular epidemiology studies, it will be impossible to interpret the risk of disease associated with the presence of newly identified susceptibility genes. As a result, molecular epidemiology is essential for the development of medical diagnostics, public health prevention strategies and discussions of the ethical, legal and social issues related to the evolution of the Human Genome Project.