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Y-axis: Incidence (/year/100,000), X-axis: age

The peak onset of MS occurs in the late 30s. It has been suggested that pubertal and sex hormone factors play a role. If the hit occurs at puberty, what does the age at onset curve tell us?

It may be that the "hit" does occur at puberty (-12 years), but the latency of disease is 20 years before symptoms appear.