Fall, 2003
Instructor: Stanley Shostak
Send me E-mail: sshostak@pitt.edu
Topics for Student Papers
(Papers cited are intended to help student get into the literature. Students
should research the literature far more extensively on their own.)
Adult Stem cells
Astrocytes
Svendsen,
C. N., The amazing astrocyte, “News and views,” Nature, 417:
29-32; 2002.
Song, H., C. F. Stevens, &
F. H. Gage, Astroglia induce neurogenesis from adult neural stem cells.
Nature, 417:
39-44; 2002.
Heart stem cells
Urbanek K., et al., Intense
myocyte formation from cardiac stem cells in human cardiac hypertrophy.
Proc. Nat. Acad. Sci. (US), 100:10440-10445; 2003.
Angiogenesis (Vasculogenesis)
LaRue, A. C., V. A. Mironov, W. S. Argraves,
A Czirok, P. A. Fleming, and C. J. Drake. Patterning of embryonic blood
vessels.
Developmental Dynamics, 228:21-29; 2003.
Apoptosis and programmed cell death
Lawson, A., Apoptosis--an introduction.
BioEssays, 29:888-896;
2003.
Cranial skeleton:
Kimmel, C. B., C. T. Miller, C.
B. Moens, Develop. Biol., 233:
239; 2001.
Cell fusion:
Wurmseter, A. E. and F. H. Gage,
Cell fusion causes confusion. “News and Views,” Nature, 416:485-487;
2002.
Chimeras:
Pearson, H., Dual identities, “News
feature,” Nature, 417:
10-11; 2002.
Cloning
Inoue, K., et al., Faithful expression of imprinted
gene in cloned mice.
Science, 295:
297; 2002.
Galli, C et al., A cloned horse born to its dam twin. Nature, 424:635;
2003.
Shaorong, G., M. McGarry, H. Priddle, T. Ferrier, B. Gasparrini, J.
Fletcher, L. Harkness, P. DeSousa, J. McWhir, and I. Wilmut. Effects of
donor oocyte and culture conditions on development of cloned mice embryos.
Molecular
Reproduction and Development, 66:126-133; 2003.
Dorsal/ventral axis formation (Drosophila):
Morisato, D., Development, 128:
2309; 2001.
Riechmann, V., A. Ephrussi, Curr.
Opin. Genet. Dev., 11:
374: 2001.
Differentiation:
van den Brink, G. R., P. De Santa
Barbara, D. J. Roberts, Epithelial cell differentiation—a matter of choice.
Science, 294:
2115?2116; 2001.
Egg receptors
Ensslin, M. A., and B. D. Shur,
Cell,
114:405-417;
2003.
Embryonic Stem Cells
Pilcher, H. R.,
Nature, "News and Views," 424:
265; 2003.
Ivanova, N. B., J. T. Domos, C. Schaniel, J. A. Hackney,
K. A. Moore, I. R. Lemischka, A stem cell molecular signature. Science, 298:
601-604; 2002.
Ramalho-Santos, M., S. Yoon, Y. Matsuzake, R. C. Mulligan,
D. A. Melton, “Stemness”: transcriptional profiling of embryonic and adult
stem cells. Science, 298:597-600;
2002.
Epigenetic Development and Imprinting:
Surani, M. A., Immaculate misconception, “News and
Views,” Nature, 416:
491-493; 2002.
Extraembryonic Mesoderm formation
Bianchi, Diana W., L. E. Wilkins-Haug, A. C. Enders,
and E. D. Hay, Origin of extraembryonic mesoderm in experimental animals:
relevance to chorionic mosaicism in humans. Am.
J. Med. Genet., 64: 542-550;
1993.
Enders, Allen C., and Harry F. King, Formation and
differentiation of extraembryonic mesoderm in the rhesus monkey. Am.
J. Anat., 181: 327-340;
1988.
Eye induction:
Kumar, J., Nature Reviews Genetics, 2: 846; 2001.
Facial skeleton:
Lee, S.-H., K. K. Fu, J. N. Hui & J. M. Richman,
Noggin and retinoic acid transform the identity of avian facial prominences.
Nature, 414:
909-912; 2002.
Gametogenesis and aneuploidy
Li, Y., J.-G. Liu, M.-R. Hoja, J. Wilbertz, K. Nordqvist,
C. Höög, Female germ cell aneuploidy and embryo death in mice
lacking the meiosis-specific protein SCP3. Science, 296:
1115-1118; 2002.
Genomics and the origin of vertebrates
Pennisi, E., Genome duplications: The stuff of evolution,
“News Focus,” Science, 294:
2458-2460; 2001.
Germ Cells: formation and migration
Germ-layer formation:
Zhang, J., W. S. Talbot, A. F. Schier, Cell, 92:
241; 1998.
Germ line
Wasserman, S. A. and S. DiNardo, Staying a boy forever.
Science,
294: 2495-2497; 2001.
Heart formation
Hanahan, D., Signaling vascular morphogenesis and maintenance.
Science,277:
48: 1997.
Harvey, R. P., NK-2 homeobox genes and heart development.
Dev.
Biol., 178: 203; 1996.
Kirby, M. L., T. F. Gale, D. E. Stewart, Neural crest
cells contribute to normal aorticopulmonary separation. Science, 220:
1059; 1983.
Kupperman, E. S. An, N. Osborne, S. Waldon, D. Y. R.
Stainier, A sphingosine-1-phosphate receptor regulates cell migration during
vertebrate heart development. Nature, 406:
192-195; 2000.
Lin, Q., J. Schwarz, C. Bucana, E. N. Olson, Control
of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science, 276:1404;
1997.
Olson, E. N. Srivastava, D., Molecular pathways controlling
heart development. Science, 272:
671; 1996.
Schultheiss,T. M., J. B. E. Burch, A. B. Lassar, A
role for bone morphogenetic proteins in the indction of cardiac myogenesis. Genes
Dev., 11: 451; 1997.
Srivastava, D., P. Cserjesi, E. N. Olson, A subclass
of 6HLH proteins required for cardiac morphogenesis. Science, 270:
1995; 1995.
Limb development
Te Welscher, P., A. Zuniga, S. Kuijper, T. Drenth,
H. J. Goedemans, F. Meijlink, R. Zeller, Progression of vertebrate limb
development through SHH-mediated counteraction of GL13. Science, 298:
827-830; 2002.
Longevity (Aging)
Murphy, C. T., et al., Genes that act downstream of
DAF-16 to influence the lifespan of
Caenorhabditis elegans. Nature,
424:277-284;
2003.
Gems, D. and J. J. McElwee, Microarraying mortality,
Nature,
"News and Views," 424:259-260; 2003.
Dillin, A., D. K. Crawford, C. Kenyon, Timing requirements
for insulin/IGF-1 signaling in C. elegans. Science, 298:
830-834; 2002.
Mesodermal partitioning: metameric somites
Holley, S. A., R. Geisler, C. Nüsslein-Volhard,
Genes
Develop., 14: 1678; 2000.
Morphogen gradients
Gurdon, J. B. & P.-Y. Bourillot, Morphogen gradient
interpretation. Nature, 413:797-803;
2001.
Neural Crest, facial and skull development:
Graveson, Ann C., Neural crest: contributions to the
development of the vertebrate head. Amer. Zool.,33:
424-433; 1993.
Pasqualetti, M. and F. M. Rijli, The plastic face,
Nature,
“News and Views,” 416:493-494;
2001.
Pancreas (stem cells)
Wolfe-Coote, S. A., J. Louw, H. M. Poerstamper and
D. F. Du Toit, Do the pancreatic primordial buds in embryogenesis have
the potential to produce all pancreatic endocrine cells? Medical Hypothesis, 31:
313-317; 1999.
Pattern formation
Blair, S. S.,
Nature, "News and Views," 424:
379-380; 2003.
Pituitary development:
Scully, K. M. and M. G. rosenfeld. Pituitary development:
regulatory codes in mamalian organogenesis. Science, 295:
2231-2235; 2002.
Sperm competition:
Anderson, M. J., A. F. Dixson, Motility and the midpiece
in primates. Nature, 416:
496; 2002.
Tail Induction
Niehrs, C., A tale of tails,
Nature, "News and Views,"
424:375;
2003.
Agathon, A., C. Thisse & B. Thisse, The molecular
nature of the zebrafish tail organizer. Nature, 424:448-452; 2003.
Last update: August. 28, 2003