Song Li, MD, PhD
Center For Pharmacogenetics
Department of Pharmaceutical Sciences
University of Pittsburgh, School of pharmacy
  • Biographic
  • Education and Training
  • Appointments and
        Positions
  • Honors and Awards
  • Membership
  • Professional Activities
  • Editorial Board
  • Journal Referee
  • Courses Taught
  • Publications
  •   Last updated
    BIOGRAPHICAL
    NameSong Li
    Business AddressCenter for Pharmacogenetics
    Department of Pharmaceutical Sciences
    University of Pittsburgh
    School of Pharmacy
    639 Salk Hall
    Pittsburgh, PA 15261
    Telephone(412) 383-7976
    Telefax(412) 648-1664
    Emialsol4@pitt.edu
    EDUCATION AND TRAINING
    Undergraduate
    1985 The Fourth Military MedicalUniversity,
    Xi’an, China
    B.S.Medicine
    Graduate
    1991Institute of Gastroenterology
    The Fourth Military Medical University,
    Xi’an, China
    Ph.D.
    M.D.
    Tumor Immno-therapy
    APPOINTMENTS AND POSITIONS
    1991-1994Xijing Hospital
    The Fourth Military Medical University
    Attending Physician
    1991-1992Xijing Hospital
    The Fourth Military Medical University
    Lecturer in Medicine
    1992-1994Xijing Hospital
    The Fourth Military Medical University
    Assist. Prof. of Medicine
    1994- July, 1996University of Pittsburgh
    Pittsburgh, PA
    Postdoc.Research Associate
    July, 1996-1998University of Pittsburgh
    Pittsburgh, PA
    Instructor in Pharmacology
    1998-2000University of Pittsburgh
    Pittsburgh, PA
    Research Assistant Professor
    July 2000-2006Center for Pharmacogenetics
    Department of Pharmaceutical Sciences
    University of Pittsburgh
    School of Pharmacy
    Pittsburgh, PA

    Assistant Professor

     

    2006-presentCenter for Pharmacogenetics
    Department of Pharmaceutical Sciences
    University of Pittsburgh
    School of Pharmacy
    Pittsburgh, PA

    Associate Professor

     

    HONORS AND AWARDS
    1989First Prize for the Presentation on the National Symposium on Digestive Diseases among Young Scientific Researchers
    1990Second Prize for The National Progress in Science and Technology
    1991Second Prize for The Military Progress in Sciences and Technology
    1993Recommended by Chinese Medical Association and Chinese Society of Immunology as the candidate for the Award for The Distinguished Young Scientists of 1993
    1994Young Clinicians (Investigators) Attendance Awards (10th World Congress of Gastroenterology, Los Angeles, CA October 2-7, 1994)
    1994Complimentary registration for the Ninth International Conference on Monoclonal Antibody Immunoconjugates for Cancer (San Diego, CA, March 3-5, 1994) (My abstract being rated as one of the top 10 abstracts)
    1997German-American Research Networking (GARN) Travel Grant
    1998NIH Travel Grant for Keystone Symposium 1998
    1999Young Investigator Award (2nd Annual Meeting of the American Society of Gene Therapy, Washington, DC June 9-13, 1999)
    MEMBERSHIP
  • American Society of Gene Therapy
  • American Physiological Society
  • American Association for the Advancement of Science
  • Member, University of Pittsburgh Cancer Institute
  • Member, Institute of Molecular Medicine, University of Pittsburgh
  • Member, McGowan Institute for Regenerative Medicine, University of Pittsburgh
  • PROFESSIONAL ACTIVITIES
    Major Research Interest
  • Immunotherapy
  • Liposome-mediated drug delivery
  • Targeted delivery of nucleic acids (plasmid DNA and antisense
        oligodeoxynucleotides)
  • Support
    HL RO1 63080 (NIH) (Song Li, M.D., Ph.D.)Lipid-Mediated Gene Transfer to Pulmonary Endothelium
    PC 001525 (DOD) (Song Li, M.D., Ph.D.) Targeted Delivery of Therapeutic Oligonucleotides for the Treatment of Prostate Cancer
    0265401U (AHA) (Song Li, M.D., Ph.D.) Targeted Gene Transfer to Pulmonary Endothelium for the Treatment of Pulmonary Hypertension
    HL RO1 68688 (NIH) (Song Li, M.D., Ph.D.)Pharmacogenetic Therapy of Pulmonary Hypertension
    0555456U (AHA) (Song Li, M.D., Ph.D.)Targeted Delivery of Synthetic SiRNA Expressing Minigenes to Plmonry Edothlium
    R21CA128415-01 (Song Li, M.D., Ph.D.)Nanosized Delivery System for Site-Specific Drug Release
    R01HL091828 (NIH) (Song Li, M.D., Ph.D.)Non Viral Gene Therapy for Lung Injury
    EDITORIAL BOARD
    2002-PresentJournal of Gene Medicine
    2006-PresentAssociate Editor, Journal of Gene Medicine
    2008-PresentBiological Procedure Online
    JOURNAL REFEREE
  • American Journal of Physiology
  • Biochimica et Biophysica Acta
  • Bioscience Report
  • BioTechniques
  • Biotechnology and Applied Biochemistry
  • Gene Therapy
  • The Journal of Gene Medicine
  • Journal of Liposome Research
  • Molecular Pharmacology
  • Nature Biotechnology
  • Pharmaceutical Research
  • Pharmaceutical Science & Technology Today
  • Biomacromolecules
  • Human Gene Therapy
  • Arteriosclerosis, Thrombosis and Vascular Biology
  • Biomaterials
  • European Journal of Pharmaceutical Sciences
  • International Journal of Pharmaceutics
  • Journal of Pharmaceutical Sciences
  • Journal of Pharmacy and Pharmacology
  • Molecular Therapy
  • Cancer Letters
  • Circulation Research
  • Pharmaceutical Science & Technology Today
  • COURSES TAUGHT
    Pharm 2007Special Topics In Drug Research
    Pharm 2001Pharmaceutical Analysis
    Pharm 3008Advanced Topics in Drug Delivery and Targeting
    Pharm 3023Foundations in Pharmaceutical Sciences
    PUBLICATIONS
    Peer Reviewed Articles (Publications in English)
  • Gao, X., Kuruba, R., Achary, D.K., Day, B.W., Liu, D., and Li, S. Polyhydroxylalkyleneamines: a class of hydrophilic polymer-based gene transfer agents. Journal of Controlled Release (in press).
  • Straub, A.C., Clark, K.A., Ross, M.A., Chandra, A.G., Li, S., Gao, X., Pagano, P.J., Stolz, D.B., and Barchowsky, A. Arsenic-stimulated sinusoidal capillarization in mice requires NADPH oxidase generated superoxide. Journal of Clinical Investigation 118: 3980-3989, 2008.
  • He, F., Zhang, Q., Kuruba, R., Gao, X., Li, J., Li, Y., Gong, W., Jiang, Y., Xie, W., and Li, S. Upregulation of decorin by FXR in vascular smooth muscle cells. Biochemical and Biophysical Research Communications 372: 746-751, 2008.
  • Lee, J.H., Gong, H., Khadem, S., Lu, Y., Gao, X., Li, S., Zhang, J., and Xie, W. Androgen deprivation by activating the liver X receptor (LXR). Endocrinology 149: 3778-3788, 2008.
  • Zhou, J., Febbraio, M., Zhai, Y., Kuruba, R., Wada, T., Khadem, S., Ren, S., Li, S., Silverstein, R., and Xie, W. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR and PPAR? to promote lipogenesis. Gastroenterology 134: 556-567, 2008.
  • Zhang, Q., He, F., Kuruba, R., Gao, X., Wilson, A., Li, J., Billiar, T.R., Pitt, B.R., Xie, W., and Li, S. FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovascular Research 77: 560-569, 2008.
  • Li, J., Wilson, A., Kuruba, R., Zhang, Q., Gao, X., He, F., Zhang, L.M., Pitt, B.R., Xie, W., and Li, S. FXR-mediated regulation of enos expression in vascular endothelial cells. Cardiovascular Research 77: 169-177, 2008.
  • Zhang, L.M., St. Croix, C.M., Cao, R., Wasserloos, K., Watkins, S.C., Stevens, T., Li, S., Tyurin, V., Kagan, V.E. and Pitt, B.R. Cell-surface protein disulfide isomerase is required for transnitrosation of metallothionein by S-nitroso-albumin in intact rat pulmonary vascular endothelial cells. Experimental Biology and Medicine 231: 1507-1515, 2006.
  • Holder, E, Griesenbach, U., Li, S., Huang L, Rogers D.F., Jeffery, P.K., Geddes, D.M., Alton, E.W. Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation. Gene Therapy 13: 1628-1638, 2006.
  • He, F., Li, J., Mu, Y., Kuruba, R., Ma, Z., Wilson, A., Alber, S., Jiang, Y., Stevens, T., Watkins, S., Pitt, P., Xie, W., and Li, S. Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circulation Research 98: 192-199, 2006.
  • Wilson, A., Zhou, W., Champion, H., Alber, S., Tang Z.-L., Kennel, S., Watkins, S., Huang, L., Pitt, B., and Li, S. Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo. Molecular Therapy 12: 510-518, 2005.
  • Ma, Z., Li, J., He, F., Wilson, A., Pitt, B., and Li, S. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochemical and Biophysical Research Communications 330: 755-759, 2005.
  • Saini, S.P.S., Mu, Y., Gong, H., Toma, D., Uppal, H., Ren, S., Li, S, Poloyac SM, and Xie, W. A paradoxical role of orphan nuclear receptor PXR in bilirubin detoxification. Hepatology 41: 497-505, 2005.
  • Li, J., Ma, Z., Tang, Z.L., Stevens, T., Pitt, B., and Li, S. CpG DNA-mediated immune response in pulmonary endothelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology 287: L552-L558, 2004.
  • Banerjee, R., Tyagi, P., *Li, S., and *Huang, L. Anisamide-targeted stealth liposomes: a potent carrier for targeting doxorubicin to prostate cancer cells. International Journal of Cancer 112: 693-700, 2004 (*co-correspondence author).
  • Yang, L., Li, J., Zhou, W., Yuan, X., and Li, S. Targeted delivery of antisense oligodeoxy-nucleotides to folate receptor-overexpressing tumor cells. Journal of Controlled Release 95: 321-331, 2004.
  • Ma, Z., Li, J., Mu, Y., Yang, L., Xie, W., Pitt,B., and Li, S. Inhibition of LPS- and CpG DNA-induced TNF-a response by oxidized phospholipids. American Journal of Physiology: Lung Cellular and Molecular Physiology 286: L808-L816, 2004.
  • Sheikh, M., Feig, J., Becky Gee, B., Li, S., Savva, M. In vitro lipofection with novel series of symmetric 1,3-dialkoylamidopropane-based cationic surfactants containing single primary and tertiary amine polar head groups. Chemistry and Physics of Lipids 124: 49-61, 2003.
  • Zhang, J., Wilson, A., Alber, S., Ma, Z., Sato, E., Mazda, O., Watkins, S., Huang, L., Pitt, B., and Li, S. Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein-Barr virus-based episomal plasmid. Gene Therapy 10: 822-826, 2003.
  • Yuan, X., Ma, Z., Zhou, W., Niidome, T., Alber, S., Huang, L., Watkins, S., and Li, S. Lipid-mediated delivery of peptide nucleic acids to pulmonary endothelium. Biochemical and Biophysical Research Communications 302: 6-11, 2003.
  • Zhou, W., Yuan, X., Wilson, A., Yang, L., Mokotoff, M., Pitt, B., and Li, S. Efficient intracellular delivery of oligonucleotides formulated in folate receptor-targeted lipid vesicles. Bioconjugate Chemistry 13: 1220-1225, 2002.
  • Ueno, N.T., Bartholomeusz, C., Xia, W., Anklesaria, P., Bruckheimer, B., Mebel, E., Paul, R., Li, S., Yoo, G.H., Huang, L., and Hung, M.C. Systemic gene therapy in human xenograft models by liposomal delivery of the E1A gene. Cancer Research 62: 6712-6716, 2002
  • Ma Z., Zhang, J., Alber, S., Dileo, J., Stolz, D., Watkins, S.C., Huang, L., Pitt, B., and Li, S. Lipid-mediated delivery of oligonucleotide to pulmonary endothelium. American Journal of Respiratory Cell and Molecular Biology 27: 151-159, 2002.
  • Ma, Z., Mi, Z., Wilson, A., Robbins, P.D., Pitt, B., and Li, S. Redirecting adenovirus to pulmonary endothelium by cationic liposomes. Gene Therapy 9: 176-182, 2002.
  • Whitmore, M.M., Li, S., Falo L., and Huang, L. Systemic administration of LPD prepared with CpG oligonucleotides eradicates established pulmonary metastases by stimulating innate and acquired antitumor immune responses. Cancer Immunology Immonotherapy 50: 503-514, 2001.
  • Tan, Y., Liu, F., Li, Z., Li, S., and Huang, L. Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity. Molecular Therapy 3: 673-682, 2001.
  • Hoffman, C.R., Dileo, J.P., Li, Z., Li, S., and Huang, L. Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity. Gene Therapy 8: 71-74, 2001.
  • Li, S., Tan, Y., Viroonchatapan, E., Pitt, B.R., and Huang, L. Targeted gene delivery to the lung by anti-PECAM antibody. American Journal of Physiology 278: L504-L511, 2000.
  • Li, B., Li, S., Tan, Y., Block, L.H., and Huang, L. Lyophilization of cationic lipid-protamine-DNA (LPD) complexes. Journal of Pharmaceutical Science 89: 355-364, 2000.
  • Whitmore, M., Li, S., and Huang, L. LPD lipopolyplex initiates a potent cytokine response and inhibits pulmonary metastatic tumor growth. Gene Therapy 6: 1867-1875, 1999.
  • Tan, Y., Li, S., Pitt, B.R., and Huang, L. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Human Gene Therapy 10: 2153-2161, 1999.
  • Li, S., Wu, S.P., Whitmore, M., Wang, L., Watkins, S. and Huang, L. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. American Journal of Physiology 276: L796-L804, 1999.
  • Li, S., Tseng, W.-C., Stolz, D.B., Wu, S.P., Watkins, S. and Huang, L. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection. Gene Therapy 6, 585-594, 1999.
  • Nikitin, A.Y., Juarez-Perez, M.I., Li, S., Huang, L. and Lee, WH. RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in RB+/- mice. Proceedings of National Academy of Sciences of USA 96: 3916-3921, 1999.
  • Brisson, M., He, Y., Li, S., Yang, J. and Huang, L. A novel T7 RNA polymerase expression vector for efficient cytoplasmic expression of target genes. Gene Therapy 6:263-270, 1999.
  • Li, S., Deshmukh, H.M. and Huang, L. Folate-mediated targeting of antisense oligodeoxynucleotides to ovarian cancer cells. Pharmaceutical Research 15: 1540-1545, 1998.
  • Li, S., Rizzo, M., Bhattacharya, S. and Huang, L. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery. Gene Therapy 5: 930-937, 1998.
  • Li, S. and Huang, L. Targeted delivery of antisense oligodeoxynucleotides formulated in a novel lipidic vector. Journal of Liposome Research 8: 239-250, 1998.
  • Li, S. and Huang, L. In vivo gene transfer via intravanous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Therapy 4: 891-900, 1997.
  • Li, S., Brisson, M., He, Y.K. and Huang, L. Delivery of a PCR amplified DNA fragment into cells: a model of using synthetic genes for gene therapy. Gene Therapy 4: 449-454, 1997.
  • Feero, W.G., Li, S., Rosenblatt, J.D., Sirianni, N., Morgan, J.E., Partridge, T.A., Huang, L., and Hoffman, E.P. Selection and use of ligands for receptor-mediated gene delivery to myogenic cells. Gene Therapy 4: 664-674, 1997.
  • Li, S., Khokhar, A.R., Perez-Soler, R., and Huang, L. Improved antitumor activity of cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) entrapped in long circulating liposomes. Oncology Research 7: 611-617, 1995.
  • Li, S., Zhang, X.Y., Qiao, T.D., Chen, X.T., Zhang, S.Y. and Chen, L.J. Enhanced antitumor activity of daunomycin conjugated with antigastric cancer monoclonal antibody MGb2. Oncology Research 4: 447-453, 1992.
  • Li, S., Zhang, X.Y., Zhang, S.Y., Chen, X.T., Chen, L.J., Shu, Y.H., Zhang, J.L. and Fan, D.M. Preparation of antigastric cancer monoclonal antibody MGb2-mityomycin C conjugate with improved antitumor activity. Bioconjugate Chemistry 1: 245-250, 1990.
  • Li, S., Zhang, X.Y., Chen, X.T., Fan, D.M., Zhang, S.Y., Chen, L.J., Shu, Y.H. and Zhang, J.L. Specific targeting of mitomycin C to tumors by anti-gastric cancer monoclonal antibody. Chinese Medical Journal 104: 358-362, 1991.
  • Li, S., Zhang, X.Y., Chen, X.T., Fan, D.M., Zhang, S.Y., Chen, L.J., Shu, Y.H., and Zhang, J.L. Preparation of anti-gastric cancer monoclonal antibody-mitomycin C conjugate and its in vitro and in vivo anti-tumor activity. Chinese Journal of Biochemistry and Biophysics 24: 207-212, 1992.
  • Li, S., Zhang, X.Y., Chen, X.T., Fan, D.M., Tan, L.S., Pan, H.Z. and Huang, L.Q. Targeted anti-tumor agents and their cytotoxicity on gastric cancer cells in vitro. Chinese Medical Journal 103: 376-379, 1990.
  • Li, S., Zhang, X.Y., Chen, X.T., et al. Selective cytotoxicity against human tumor cells by an anti-gastric cancer monoclonal antibody-mitomycin C conjugate. Acta Pharmacologica Sinica 11: 367-370, 1990.
  • Li, S., Zhang, X.Y., Chen, X.T., Fan, D.M., Tan, L.S., Pan, H.Z., Huang, L.Q. and Gu, Y.Q. Selective killing of gastric cancer cells by monoclonal antibody conjugated with A chain of ricin. Chinese Journal of Cancer Research 1: 34-38, 1989.
    Publications in Chinese
  • Li, S., Zhang, X.Y., Hu, J.L., Fan, D.M., Qiao, T.D., Zhang, S.Y. and Chen, L.J. Preparation of an anti-gastric cancer monoclonal antibody-mitomycin C conjugate via a new type of conjugation method (abstract in English). Chinese Journal of Microbiology and Immunology 14: 108-111, 1994.
  • Qiao, T.D., Wang, F.A., Li, S., Zhang, X.Y. and Fan, D.M. Whole body autoradiography in immunoconjugate localization in nude mice bearing human colon cancer xenografts: a comparative study with SPECT imaging scanning procedure (abstract in English). Chinese Journal of Physical Medicine 15: 65-69, 1993.
  • Wang, F.A., Li, S., Ding, J. and Zhang, S.Y. Immuno-ricin A chain specific for gastric cancer: internalization and its significance (abstract in English). National Medical Journal of China 72: 401-404, 1992.
  • Li, S., Zhang, X.Y., Chen, X.T. and Fan, D.M. Cytotoxicity of indirect immunotoxin mediated by anti-gastric cancer monoclonal antibodies on tumor cells (abstract in English). Chinese Journal of Microbiology and Immunology 10: 36-38, 1990.
  • Li, S., Zhang, X.Y., Chen, X.T., and Fan, D.M., In vitro cytotoxicity of a human serum albumin-mediated conjugate of mitomycin C with anti-gastric cancer monoclonal antibody (abstract in English). Shanghai Journal of Immunology 10: 166-168, 1990.
  • Li, S., Zhang, X.Y., Chen, X.T., Fan, D.M., Zhang, S.Y., Chen, L.J., Shu, Y.H., and Zhang, J.L. Inhibitory effect of anti-gastric cancer monoclonal antibody-mitomycin C conjugate on the growth of human gastric carcinoma (SGC-7901) transplanted under the kidney capsule of nude mice (abstract in English). Chinese Journal of Digestion 10: 313-315, 1990.
  • Zhang, S.Y., Li, S., Chen, L.J., Shu, Y.H., Zhang, X.Y. and Chen, X.T. Effects of immuno-drug conjugates on growth of human gastric cancer xenograft in subrenal capsule of nude mice (abstract in English). Acta Pharmacologica Sinica 11: 556-560, 1990.
  • Li, S., Zhang, X.Y., Chen, X.T., Fan, D.M., Tan, L.S., Pan, H.Z., Hu, J.W., Huang, L.Q. and Gu, Y.Q. Preparation and characterization of immunotoxin with blocked galactose-binding sites of ricin (abstract in English). Chinese Journal of Pharmacology and Toxicology 3: 81-84, 1989.
    Reviews and Book Chapters
  • Kuruba, R., Wilson, A., Gao, X., and Li, S. Targeted delivery of nucleic acids-based therapeutics to pulmonary circulation. The AAPS Journal (in press).
  • Wipf, P., Gong, H., Janjic, J.M., Li, S., Day, B.W., and Xie, W. New opportunities for pregnane X receptor (PXR) targeting in drug development: lessons from enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues. Mini-Reviews in Medicinal Chemistry 7: 617-625, 2007.
  • Li, S-D., Li, S., and Huang, L. Lipoplex and LPD Nanoparticles for In Vivo Gene Delivery. In “Gene Transfer. Delivery and Expression of DNA and RNA”, Eds, Friedman, T and Rossi J. Cold Spring Harbor Laboratory Press. Chapter 39, pp 433 – 438, 2006.
  • Wilson, A., He, F., Li, J., Ma, Z., Pitt, B., and Li, S.. Targeted delivery of therapeutic oligonucleotides to pulmnary circulation. Advances in Genetics 54: 21-41, 2005.
  • Zhang, J.S., Li, S., and Huang, L. Cationic liposome-protamine-DNA complexes for gene delivery. Methods Enzymol. 373:332-342, 2003.
  • Wilson, A., Pitt, B., and Li, S. Complex Roles of CpG in Liposomal delivery of DNA and oligonucleotides. Bioscience Report 22: 309-22, 2002.
  • Tan, Y., Whitmore, M., Li, S., Frederik, P., and Huang, L. LPD nanoparticles--novel nonviral vector for efficient gene delivery. Methods Mol Med 69: 73-81, 2002.
  • Li, S., Ma, Z., Tan, Y., Liu, F., Dileo, J., and Huang, L. Targeted gene delivery via lipidic vectors. In: “Vector Targeting for Therapeutic Gene Delivery” D. Curiel & J. Douglas (eds). John Wiley and Sons, Inc., New York, pp17-32, 2002.
  • Li, S., and Ma, Z. Non-viral gene therapy. Current Gene Therapy 1: 201-226, 2001.
  • Li, S. and Huang, L. Nonviral gene therapy: promises and challenges (a millennium review). Gene Therapy 7: 31-34, 2000.
  • Whitmore, M., Li, S., and Huang, L. Liposome vectors for in vivo gene delivery. In: “Current Protocols in Human Genetics” NC Dracopoli et al (Eds.). John Wiley and Sons, Inc., New York, Unit 12.8, 1999.
  • Li, S. and Huang, L. Novel lipidic vectors for gene transfer. In “Non-Viral Vectors for Gene Therapy” L. Huang, M.C. Hung, and E. Wagner (Eds.) Academic Press pp287-307, 1999.
  • Li, S. and Huang, L. Functional pleomorphism of liposomal gene delivery vectors: lipoplex and lipopolyplex. In “Liposomes: Rational Design” A.S. Janoff (Ed.). Marcel Dekker, Inc. pp89-124, 1998.
  • Huang, L and Li, S. Liposomal gene delivery- a complex package. Nature Biotechnology 15: 620-621, 1997.
  • Li, S. and Huang, L. Targeted delivery of antisense oligodeoxynucleotides by LPDII. Journal of Liposome Research 7: 63-75, 1997.
  • Li, S. and Huang, L. Protamine sulfate provides enhanced and reproducible intravenous gene transfer by cationic liposome/DNA complex. Journal of Liposome Research 7: 207-219, 1997.
  • Huang, L. and Li, S. Intravenous delivery of genes: introduction to the forum. Journal of Liposome Research 7: vii-xi, 1997.
  • Li, S., Gao, X., Son, K., Sorgi, F., Hofland, H. and Huang, L. DC-chol lipid system in gene therapy. Journal of Controlled Release 39: 373-381, 1996.
  • Li, S. and Huang, L. Lipidic supramolecular assemblies for gene transfer. Journal of Liposome Research 6: 589-608, 1996.
  • Li, S., Zhang, X.Y., and Hu, J.L. Bioconjugation of macromolecules (in Chinese). In “Internalization of Biomacromolecules” (F.A. Wang, X.Y. Zhang and J.L. Hu, Eds.) (D.A. McClain & A. Levitzki, Honorary Eds.) pp207-221, Science Press, Beijing, China, 1995.
  • Zhang, X.Y., Li, S., and Fan, D.M. Uses of MG series monoclonal antibodies in the daignosis and experimental targeting therapy of gastric cancer. Chinese Medical Sciences Journal 6: 56-59, 1991.