The Saxena Group at U. Pittsburgh

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Publications, Patents and Programs

(* indicates publications based on research at the University of Pittsburgh )

^*(33) ESR spectroscopy identifies inhibitory Cu(II) sites in a DNA modifying enzyme to reveal determinants of catalytic specificity, Z. Yang, M. Kurpiewski, M. Ji, J. E. Townsend, P. Mehta, L. Jen-Jacobson, and S. Saxena, Proc Natl. Acad. Sci. Plus 109 (2012) 6366 [pg E993 on pnas.org]. (dx.doi.org/10.1073/pnas.1200733109)

^*(32) Simulating the dynamics and orientations of spin labeled side chains in a protein-DNA complex, J. L. Sarver, J.E. Townsend, G. Rajapakse, L. Jen-Jacobson, and S. Saxena, J. Phys. Chem. B 116 (2012) 4024. (dx.doi.org/10.1021/jp211094n)

^*(31) Insight into potential Cu(II)-binding motifs in the four pseudorepeats of Tau protein, B.-k. Shin, S. Saxena, J. Phys. Chem. B 115 (2011) 15067. (dx.doi.org/10.1021/jp204410h)

^*(30) Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in Amyloid-ß(1-16) at physiological pH and its significance, B.-k. Shin, S. Saxena, J. Phys. Chem. A 115 (2011) 9590. (dx.doi.org/10.1021/jp200379m)

^*(29) Practical Aspects of copper-ion based DEER distance measurements, Z. Yang, M. Ji, S. Saxena, Appl. Magn. Reson. 39 (2010) 487.

^*(28) Pulsed ESR resolves the coordination site of Cu(II) ions in a1-GlyR, S. Ruthstein, K. M. Stone, T. F. Cunningham, M. Ji, M. Cascio, S. Saxena, Biophys. 99 (2010), 2497. (doi:10.1016/j.bpj.2010.08.050)

^*(27) An approach to the measurement of nanometer range distances based on Cu(II) ions and ESR, Z. Yang, D. Kise, S. Saxena, J. Phys. Chem. B. 114 (2010), 6165. (http://pubs.acs.org/doi/pdf/10.1021/jp911637s)

^*(26) The second Cu(II)-binding site in a proton rich environment interferes with the aggregation of Amyloid-ß(1-40) into amyloid fibrils, S. Jun, J. R. Gillespie, B.-Y. Shin, S. Saxena, Biochem. 48 (2009), 10724. (http://pubs.acs.org/doi/abs/10.1021/bi9012935)

^*(25) Electron spin resonance analysis of the mechanism of pericyclic reactions of bicyclobutanes, M. A. A. Walczak, B.-k. Shin, P. Wipf, S. Saxena, Org. Biomol. Chem. 7 (2009), 2363. (http://dx.doi.org/10.1039/b815469b)

^*(24) Electron spin resonance shows common structural features for different classes of EcoRI-DNA complexes, K. Stone, J. E. Townsend, J. Sarver, P. J. Sapienza, S. Saxena, L. Jen-Jacobson, Angew Chem. 47 (2008), 10192. (http://dx.doi.org/10.1002/anie.200803588)

^*(23) Distance distributions of end-labeled curved bis-peptide nanostructures by electron spin resonance, G. H. Bird, S. Pornsuwan, S. Saxena, C. E. Schafmeister, ACS Nano 2 (2008) 1857. (http://dx.doi.org/10.1021/nn800327g)

^*(22) Direct evidence that all three histidine residues coordinate to Cu(II) in amyloid-ß(1-16), B.-k. Shin and S. Saxena, Biochem. 47 (2008), 9117. (http://dx.doi.org/10.1021/bi801014x)

^*(21) Analysis of the dynamical flexibility of bis-peptide nanostructures, S. Pornsuwan, C. E. Schafmeister, and S. Saxena, J. Phys. Chem. C, 112 (2008), 1377. (http://dx.doi.org/10.1021/jp077523e)

^*(20) On Cu(II)-Cu(II) distance measurement by pulsed electron-electron double resonance, Z. Yang, J. S. Becker, and S. Saxena, J. Magn. Reson. 188 (2007) 337. (http://dx.doi.org/10.1016/j.jmr.2007.08.006)

^*(19) The aggregated state of amyloid-ß peptide in vitro depends on Cu(II) concentration, S. Jun, and S. Saxena, Angew. Chem., Inter. Ed., 46 (2007) 3959. (http://dx.doi.org/10.1002/anie.200700318)

^*(18) Lengths and Flexibility of bis-peptide nanostructures using electron spin resonance, S. Pornsuwan, G. Bird, C. E. Schafmeister, and S. Saxena, J. Am. Chem. Soc., 2006, 128, 3876. (http://dx.doi.org/10.1021/ja058143e)

^*(17) Unfolding of alanine-based peptides using electron spin resonance distance measurements, S. Jun, J. Becker, M. Yonkunas, R.Coalson, and S. Saxena, Biochemistry, 45 (2006), 11666 -11673. (http://dx.doi.org/10.1021/bi061195b)

^*(16) Double Quantum Coherence electron spin resonance on coupled Cu(II)-Cu(II) spins, J. Becker, and S. Saxena, Chem. Phys. Lett. 414 (2005) 248. (http://dx.doi.org/10.1016/j.cplett.2005.08.072)

^*(15) Binding of Cu(II) to thyrotropin-releasing hormone (TRH) and its analogs”, R. Meng, J. Becker, F.-T. Lin, S. Saxena, and S. G. Weber, Inorg. Chim. Acta, 358 (2005) 2933.

^*(14) Suppression of electron spin echo envelope modulation peaks in double quantum coherence electron spin resonance, M. Bonora, J. Becker, and S. Saxena, J. Magn. Reson.170 (2004) 278. (http://dx.doi.org/10.1016/j.jmr.2004.07.006)

^*(13) Nitroxide spin-relaxation over the entire motional range, M. Bonora, S. Pornsuwan, S. Saxena , J. Phys. Chem.B 108 (2004) 4196. (http://dx.doi.org/10.1021/jp0365864)

(12) Amplification of xenon NMR and MRI by remote detection , A. J. Moule, M. M. Spence, S.-I. Han, J. A. Seeley, K. L. Pierce, S. Saxena, and A. Pines, Proc. Natl. Acad. Sci. 100 (2003) 9122.

(11) Laser polarized ¹²⁹Xe NMR and MRI at ultra-low magnetic fields , A. Wong-Foy, S. Saxena, A. J. Moule, H. M. L. Bitter, J. A. Seeley, R. McDermott, J. Clarke and A. Pines, J. Magn. Reson. 157 (2002) 235.

(10) Resolution of Xenon-129 Chemical Shifts at Ultra low Magnetic Field , S. Saxena, A. Wong-Foy, A. J. Moule, J. A. Seeley, R. McDermott, J. Clarke and A. Pines, J. Am. Chem. Soc. 123 (2001) 8133.

(9) Solid state ²H-NMR studies of segmental dynamics in polymer blends , S. Saxena, D. Cizmeyciyan, J. A. Kornfield, Solid State Nuclear Magnetic Resonance 12 (1998) 165.

(8) Two-dimensional electron spin resonance and slow motions , S. Saxena and J. H. Freed, J. Phys. Chem. A 101 (1997) 7998.

(7) Theory of double quantum two dimensional electron spin resonance with application to distance measurements , S. Saxena and J. H. Freed, J. Chem. Phys. 107 (1997) 1317.

(6) Absorption lineshapes in two dimensional electron spin resonance and the effects of slow motions in complex fluids , S. Saxena and Jack H. Freed, J. Magn.Reson. 124 (1997) 439.

(5) A theoretical approach to the analysis of arbitrary pulses in magnetic resonance , K. M. Salikhov, D. J. Schneider, S. Saxena and J. H. Freed, Chem. Phys. Lett. 262 (1996) 17.

(4) Double quantum two dimensional Fourier transform electron spin resonance: Distance measurements , S. Saxena and J. H. Freed, Chem. Phys. Lett. 251 (1996) 102.

(3) Non linear least-squares analysis of slow motional EPR spectra in one and two dimensions using a modified Levenberg-Marquardt Algorithm , D. E. Budil, S. Lee, S. Saxena and J. H. Freed, J. Magn. Reson. A 120 (1996) 155.

(2) Studies on lipid membranes by two dimensional Fourier transform ESR: Enhancement of resolution to ordering and dynamics , R. H. Crepeau, S. Saxena, S. Lee, B. Patyal, and J. H. Freed Biophys. J. 66 (1994) 1489.

(1) Two-dimensional Fourier transform electron spin resonance in complex fluids'', S. Lee, B. R. Patyal, S. Saxena, R. H. Crepeau and J. H. Freed, Chem. Phys. Lett. 221 (1994) 397.

Remote NMR/MRI detection of laser polarized gases A. Pines, S. K. Saxena, A. Moule, M. Spence, J. A. Seeley, K. L. Pierce, S.-I. Han, J. Granwehr, US Patent No. 7,061,237 B2.

Updated on November 17, 2011

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