ABCA1 transporter and LXR: emerging players and new targets in AD
Sanders-Brown Center on Aging, Lexington, KY July, 2010.
Role of Abca1 transporter and LXR receptors in AD
Department of Environmental and Occupational Health, University of Pittsburgh September, 2009.
LXR agonists for treatment of Alzheimer's amyloidosis
ICAD Meeting, Chicago, IL July, 2008.
ABCA1 Transporter: A Therapeutic Target for Alzheimer's disease
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY July 6, 2006.
LXR agonists for the treatment of Alzheimer's amyloidosis
“Obesity and Alzheimer's Disease Workshop”, NIH/NIA Workshop, June 20-21, 2006, Washington, DC.
LXR and PPAR g Synthetic Ligands Upregulate ABCA1 Expression and Decrease A b Secretion
International Conference on Prevention of Dementia: Early diagnosis and intervention. June 20, 2005, Washington, D.C.
Fitz, N., Lefterov, I., Koldamova, R. Role of Abca1 in Alzheimer's pathology and cognition. Presentation: University of Pittsburgh Postdoctoral Association: Data and Dine, Pittsburgh PA, June 2009
Andrea A. Cronican. Nicholas Fitz, Allison Fogg, Sean Egglestone, Tim Tulloch, Priya Rajendran, Iliya Lefterov, and Radosveta P. Koldamova. “Effect of Abca1 and brain lipoproteins on in vivo Aβ clearance in APP/PS1 mice”. Presented at SfN meeting, Chicago, Oct 17-21, 2009.
Allison. L. Fogg, N. F. Fitz, A. A. Cronican, S. Egglestone, T. Tulloch, P. Rajendran, I. Lefterov, R. Koldamova. Lack of ApoA-I increases amyloid deposition and aggravates memory deficits in APP/PS1 mice. Presented at SfN meeting, Chicago, Oct 17-21, 2009.
Nicholas F. Fitz, Andrea A. Cronican, Allison L. Fogg, Sean Egglestone, Tim Tulloch, Iliya Lefterov & Radosveta Koldamova. LXR ligand treatment in APP23 mice on normal and high fat diet. Presented at SfN meeting, Chicago, Oct 17-21, 2009.
Fitz, N., Lefterov, I., Koldamova, R. Role of Abca1 in Alzheimer's pathology and cognition. Presentation: University of Pittsburgh Postdoctoral Association: Data and Dine, Pittsburgh PA, June 2009.
Fitz, N., Lefterov, I., Koldamova, R. Influence of Abca1 on Alzheimer's pathology and cognition.
Presentation: Celebrating Research on Aging, Pittsburgh PA, December 2008.
Koldamova, R., Fitz, N.; Cronican, A., Lefterov, P., Lefterov, I., Regulatory role of Abca1 and brain
lipoproteins in Ab oligomerization and deposition - comparative pathology in ABCA1ko and ApoAIko/ApoEko mice. 2008 Society for Neuroscience Meeting, Washington D.C., November 2008.
Fitz, N., Lefterov, I., Lefterov, P., Staufenbiel, M., Koldamova, R. Amyloid beta oligomerization and
fibrillization associated with working memory impairments in APP23/ABCA1+/- mice - implications for
the role of ABCA1 in Alzheimerʼs disease. 2008 Society for Neuroscience Meeting, Washington D.C.,
November 2008.
Fitz, N., Lefterov, I., Lefterov, P., Koldamova, R. Implications for the role of ABCA1 in Alzheimer's
disease. SCIENCE 2008, Pittsburgh PA, August 2008.
R. Koldamova, A. Bookout, M. Staufenbiel, D. Mangelsdorf, I. Lefterov. “Long-term LXR ligand treatment increases soluble ApoE and decreases insoluble Ab in older APP23 mice”. Presented at the Society for Neuroscience Meeting in Atlanta, GA., October 13-18, 2006.
I. Lefterov, A. Bookout, M. Staufenbiel, D. Mangelsdorf, R. Koldamova. “Effects of LXR ligands on inflammatory response in primary microglia and AD transgenic animals” Presented at the Society for Neuroscience Meeting in Atlanta, GA., October 13-18, 2006.
William E. Klunk, Brian J. Lopresti, Manik L. Debnath, Guo-feng Huang, Li Shao, Iliya Lefterov, Radosveta Koldamova, Milos D. Ikonomovic, Steven T. DeKosky, Chester A. Mathis, University of Pittsburgh, Pittsburgh, PA, USA. “Low Binding of the Amyloid PET Tracer, PIB, to Transgenic PS1/APP Mouse Brain Compared to Human AD Brain Explained by Bmax”. Presented at the Alzheimer's Association International Prevention of Dementia Conference in Washington, D.C., USA, June 18 – 21, 2005.
William E. Klunk, Brian J. Lopresti, Manik L. Debnath, Daniel P. Holt, Yanming Wang, Guo-feng Huang, Li Shao, Iliya Lefterov, Radosveta Koldamova, Milos Ikonomovic, Steven T. DeKosky, Chester A. Mathis (2004). Amyloid Deposits in Transgenic PS1/APP Mice Do Not Bind the Amyloid PET Tracer, PIB, in the Same Manner as Human Brain Amyloid. Neurobiology of Aging; Vol. 25, (S2): 232
Iliya Lefterov, Radosveta Koldamova, Matthias Staufenbiel, Milos Ikonomovic, Barbara Isanski, Steven T. DeKosky, John S. Lazo (2004) LXR ligand treatment in vitro and in vivo is followed by ABCA1 upregulation and decrease in Ab secretion. Neurobiology of Aging; Vol. 25, (S2): 569
