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Patricia Opresko - Teaching and Mentoring
Courses Taught
Years Taught Course Number: Title Primary Instructor Spring 2006, 2008, 2010, 2012, 2014, 2016 EOH 3305, MSMPHL 3330 and MSBMG 3530: DNA Repair - from biochemistry to human disease Co-director with Drs. Bennett Van Houten and Chris Bakkenist Spring 2015 EOH 3210: Pathophysiology and Environmental Disease Lecturer Fall 2015 EOH 2310: Molecular Fundamentals Drs. Patricia Opresko and Peter Di
2013 - 2015 MLB 1: Methods and Logic in Biomedicine Drs. Patricia Opresko and Peter Drain Spring 2012 EOH 3305, MSMPHL 3330 and MSBMG 3530: DNA Repair - from biochemistry to human disease Drs. Robert Sobol, Laura Niedernhofer, and Patricia Opresko
Fall 2012 EOH 2310: Molecular Fundamentals Drs. Patricia Opresko and Peter Di
Summer 2008, 2010, 2012, 2014, 2016 EPIDEM 2980 Biology and Physiology of Aging 1 Lecture Dr. Ann Newman Fall 2011 MSELCT 5130-1020. M.S.T.P. Research Basis of Medical Knowledge University of Pittsburgh School of Medicine, MD/PhD program, second year students
Co-director with Dr. Bennet van Houten Spring 2010 EOH 3305, MSMPHL 3330 and MSBMG 3530: DNA Repair - from biochemistry to human disease Drs. Robert Sobol, Laura Niedernhofer, and Patricia Opresko Fall 2010, 2011, 2014, 2015, 2016 HUGEN 2031 Introduction to Human Genetics Lecture: DNA repair defects; chromosomal breakage syndromes; cancer predisposition
Dr. Suzanne Gollin Spring 2010 EOH 2310: Molecular Fundamentals Drs. Patricia Opresko and Peter Di Spring 2008 MSMPHL 3330 and MSBMG 3530: DNA Repair - from biochemistry to human disease Biochemistry and Molecular Genetics graduate course 1. Lecture 18: Damage Processing at Telomeres 2. Lecture 22: Helicase (BLM, WRN) in damage processing 3. Lecture 23: Processing Syndromes Werner, Bloom, NBS1, ATLD, RTS Drs. Robert Sobol and Laura Niedernhofer Spring 2008 EOH 2310: Molecular Fundamentals Environmental and Occupational Health Graduate Program 1. Lecture 7: Proteins 2. Lecture 8: Enzymology 3. Lecture 20: DNA Damage and Repair 4. Lecture 21: Mutagenesis Dr. Sye Garte Fall 2007 - 2016 EOH 2175: General Toxicology University of Pittsburgh School of Public Health Lecture: Genetic Toxicology Lecture: Carcinogenesis Dr. James Fabisiak Fall/Spring 2006/2007, 2007/2008, 2008/2009, 2009/2010, 2010/2011 M.S.T.P. Research Basis of Medical Knowledge University of Pittsburgh School of Medicine, MD/PhD program Co-director with Dr. Richard Steinman Fall 2006 EOH 2310: Molecular Fundamentals Environmental and Occupational Health Graduate Program Biochemistry and Metabolism section: 7 lectures Dr. Paul Reynolds Spring 2006 MSMPHL 3330 and MSBMG 3530: DNA Repair - from biochemistry to human disease Biochemistry and Molecular Genetics graduate course 1. Lecture 19: Other diseases with defective damage processing
2. Lecture 23: Manuscript on Werner Syndrome and Premature AgingDr. Richard Wood Fall 2005 EOH 2310: Molecular Fundamentals
Environmental and Occupational Health Graduate Program
1. Lecture 21: Protein PurificationDr. Paul Reynolds Mentoring
Date(s) Type of Teaching Title Fall 2006 Presented a 1hr. lecture titled Basic orientation to 'bench' biomarkers of age with an emphasis on telomeres to faculty, post-doctoral fellows and graduate students. Biomarkers of Aging Workshop November 7, 2006 The Pittsburgh Mind-Body Center Fall 2006 Served as a preceptor for analysis of the article "The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma." Smela 2002 PNAS. EOH 2176: Principles of Toxicology Conference EOH Graduate Program Fall 2006 Served as a preceptor for analysis of the article "Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity". Matsutani 1999 EMBO J EOH 2176: Principles of Toxicology Conference EOH Graduate Program Spring 2006
Lectured on my experience with the peer review process for a recent publication “POT1 Stimulates RecQ Helicases WRN and BLM to Unwind Telomeric DNA Substrates” Opresko et al., 2005, Journal Biological Chemistry. EOH 2109: Graduate Program in Molecular Toxicology Journal Club Fall 2005
Served as a mentor/preceptor for the student presentation of the article “DNA Helicase Srs2 disrupts the Rad51 presynaptic filament” Krejci 2003 Nature. EOH 2311: Molecular Fundamentals Conference.
EOH Graduate ProgramFall 2005
Served as a faculty mentor for Aaron Secrest and Oni Obi for their presentation of the journal article “Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity” Crabbe et al, 2004, Science. Journal Club 2 nd year MD/PhD students Fall/Spring 1996-97 Tutored Medical Students for the Biochemistry course Dept. Biochemistry, Pennsylvania State University School of Medicine Other Teaching/Training
Date(s) Type of Teaching Program/Description Summer 2016-17 Adam Barsok, mentored undergraduate Undergraduate internship Summer 2015 Adam Barsok, mentored high school student UPCI Academy Spring 2015 Mentored Lisa Clark, PhD Student in MBSB program MBSB MB2 class; student present a research article from a selected mentors’ lab Fall 2014 Mentored rotation medical student Lu Yang University of Pittsburgh and Tsinghua University Medical Research Scholars program Spring 2014 Mentored rotation graudate student Meghan Sullivan Molecular Genetics and Developmental Biology graduate program University of Pittsburgh School of Medicine Fall 2013 Mentored rotation medical student Jingei Chen University of Pittsburgh and Tsinghua University Medical Research Scholars program Fall 2013 Mentored rotation medical student Hanqi Tang University of Pittsburgh and Tsinghua University Medical Research Scholars program Summer 2013 Supervised undergraduate Laura Congelio EOH summer undergraduate research program Summer 2012 Supervised a high school student in the lab, Ashley Grinage PITT STEER program, Short Term Education Experience in Research Spring/Summer 2012 Supervised Human Genetics Masters student, Cassandra Krise Work study student Spring 2011 Supervised and mentored an undergraduate student- Steven Strutt EOH summer undergraduate research program Summer 2009 Supervised and mentored a first year medical student-Nathan Smith Medical Student Training in Aging Research (MSTAR) Program sponsored by The American Federation for Aging Research and the National Institute on Aging Summer 2009 Supervised and mentored an undergraduate student- Devin Kepchia EOH summer undergraduate research program Winter 2009 Workshop with GSPH graduate students Dean’s Day abstract preparation session Summer/Fall 2008 Supervised and mentored an undergraduate student- Abbe Jackson EOH summer undergraduate research program Summer 2006 Supervised and mentored an undergraduate student- Hannah Colabrese EOH summer student Summer 2004 Supervised and mentored a M.S. graduate student – Shamika Danzy NIH Summer Internship Program
Dates Served Name of Student Degree Awarded Title of Dissertation/Essay 4/21/2016
thesis defenseStanley Oyaghire PhD, Chemistry, Carnegie Mellon University Recognition of Guanine Quadruplexes by PNA and Gamma-PNA Oligomers 6/15 – present Meghan Sullivan PhD, Molecular Genetics and Developmental Biology Program TBA 6/14 - present Muwen Ben Kong PhD, Molecular Structural Biology and Biophysics TBA 2/28/14 - present Kyle Knickelbein PhD, Chemical Biology and Pharmacology TBA 12/3/2013 – 1/2016 Dushani Palliyaguru PhD, Environmental and Occupational Health Characterizing Withaferin A as a novel Nrf2 inducer: implications for liver disease prevention 12/18/2013 - present Sean Carney PhD, Molecular Structural Biology and Biophysics TBA 8/23/2013 – 12/2015 Stephen K. Godin PhD, Molecular Genetics and Developement Biology program The Shu complex is a conserved regulator of Rad51 filament formation 2/3/2012 Karin Solvang-Garten PhD Molecular Medicine X-ray Repair Cross-Complementing Protein 1 – the roles as a scaffold protein in Base excision repair and Single strand break repair
Norwegian University of Science and Technology, Trondheim, Norway4/2010-6/2012 Advaitha Madireddy PhD Human Genetics Linking the Multiple Functions of XPF-ERCC1 Endonuclease in DNA Repair to Health Outcomes: Cancer and Aging
Service on Comprehensive or Qualifying Examination Committees (past 5 years)
Dates Served Student Population Type of Exam 6/2016 Emily Beckwitt, PhD student, Molecular Biophysics and Structural Biology Program Comprehensive Exam, chair 6/2016 Emilie Castronio, PhD student, Environmental and Occupational Health Qualifying Exam, chair 6/2014 Kindra Witlatch, PhD student, Molecular Biophysics and Structural Biology Program Comprehenisve Exam, chair 6/2014 Meghan Sullivan, PhD student, Molecular Genetics and Developmental Biology Program Comprehensive Exam 11/2014 Teresa Anguiano, PhD student, Environmental and Occupational Health Qualifying Examination, chair 10/24/13 Amin Cheikhi, 1 PhD student, Environmental and Occupational Health Qualifying Examination, chair 7/29/13 Stephen K. Godin, 1 PhD student, Molecular Genetics and Developemental Biology program Comprehensive Examination 7/23/13 Courtney Roper, 1 PhD EOH student Qualifying Examination, chair 7/9/13 Muwen Ben Kong, 1 PhD student, Molecular Biophysics and Structural Biology program Comprehensive Examination 12/7/11 Shilpi Oberoi, 1 PhD EOH student Qualifying Examination, chair Supervision of Post-Doctoral Students, Residents, and Fellows (past 5 years)
Dates Supervised Name of Student Position of Student 8/2015 - Present Arindam Bose Postdoctoral fellow 6/2014 - Present Elise Fouquerel Postdoctoral fellow
2/2011 – 12/31/14 Connor Murphy Imaging & Microscopy Specialist, B&B Microscopes, Pittsburgh, PA 9/2007 – 3/2011 Fujun Liu Postdoctoral fellow, now Manager of Product Safety of LBrand, NJ