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Department of Environmental and Occupational Health

Patricia Opresko - Publications (past 5 years)

Opresko, P.L., Calvo, J.P. and von Kobbe, C. Essential role of the Werner syndrome protein in oncogenic proliferation of human cancer cells. Mech Ageing Dev. 2007 Jul-Aug;128(7-8):423-36. Epub 2007 May 31. PMID: 1762441

Opresko PL. Telomere ResQue and preservation-Roles for the Werner syndrome protein and other RecQ helicases. Mech Ageing Dev. 2008 Jan-Feb; 129 ( 1-2 ): 79-90 . Epub 2007 Oct 30. PMID: 18054793

Sowd, G., Lei, M., and Opresko, P.L. (2008) Mechanism and Substrate Specificity of Telomeric Protein POT1 Stimulation of the Werner Syndrome Helicase. Accepted in Nucleic Acids Research Jun 25.  PMID: 18583366

Opresko PL, Sowd G, Wang H. The Werner Syndrome Helicase/exonuclease Processes Mobile D-loops Through Branch Migration and Degradation.  PLoS ONE. 2009;4(3):e4825. Epub 2009 Mar 13. PMID: 19283071

Sanders, J., Cauley, J., Boudreau, R., Zmuda, J., Strotmeyer, E., Opresko, P., Hsueh, W.C., Cawthon,R., Li, R., Harris,T., Kritchevsky, S., Newman A.  Leukocyte Telomere Length is Not Associated with Bone Mineral Density, Osteoporosis, or Fracture in Older Adults: Results from the Health, Aging and Body Composition Study. J Bone Mineral Research. 2009, in press.

Liu FJ, Barchowsky A, Opresko PL. The Werner Syndrome Protein Functions in Repair of Cr (VI)-induced Replication.  Associated DNA Damage. Toxicol Sci. 2009 Jun 1; 110: 307-18. PMID: 19487340

Sowd, S., Wang, H., Pretto, D., Chazin, W.J. and Opresko, P.L. Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration Activity. Journal of Biological Chemistry, 2009. 284: 34682-91.

Shah, S., Opresko, P., Xiao, M., Lee, M., and Eckert, K. DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Research, 2010. 38: 1149-62.

Nora, G., Buncher, A., and Opresko, P.L. Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner Syndrome helicase. Nucleic Acids Research, 2010 Jul 1;38(12):3984-98. Epub 2010 Mar 9. PubMed PMID: 20215438

Kusumoto-Matsuo R., Opresko, P.L., Ramsden D., Tahara, H. and Bohr, V.A. Cooperation DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops. Aging, 2010, in press.

Liu FJ, Barchowsky A, Opresko PL. The Werner Syndrome Protein Suppresses Telomeric Instability Caused by Chromium (VI) Induced DNA Replication Stress. PLoS One. 2010 Jun 16;5(6):e11152. PubMed PMID: 20585393

Damerla RR, Knickelbein KE, Kepchia D, Jackson A, Armitage BA, Eckert KA, Opresko PL. Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability. DNA Repair (Amst). 2010 Nov 10;9(11):1119-29. Epub 2010 Aug 25. PubMed PMID: 20800555

Wang H, Nora GJ, Ghodke H, Opresko P. Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveals Pot1 Mechanism for Promoting G-Quadruplex Unfolding. J Biol Chem. 2010 Dec 23. PMID: 21183684

Sanders JL, Iannaccone A, Boudreau RM, Conley YP, Opresko PL, Hsueh WC, Cummings SR, Cawthon RM, Harris TB, Nalls MA, Kritchevsky SB, Newman AB; for the Health ABC Study. The Association of Cataract With Leukocyte Telomere Length in Older Adults: Defining a New Marker of Aging. J Gerontol A Biol Sci Med Sci. 2011 Jun;66A(6):639-645. Epub 2011 Mar 7. PMID:21382885

O'Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES; for the Health Aging and Body Composition Study. Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study. PLoS One. 2011;6(5):e19687. Epub 2011 May 13. PMID: 21602933

Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus. 2011 Nov-Dec;2(6):570-9. Epub 2011 Nov 1. PMID: 22127259

Miller A, Balakrishnan L, Buncher NA, Opresko PL, Bambara RA. Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro. Cell Cycle. 2012 Mar 1;11(5). PMID: 22336916

Damerla, R.R., Knickelein, K.E., Strutt, S., Liu, F.-J., Wang, H., Opresko, P.L. The Werner Syndrome protein suppresses the formation of large deletions during the replication of human telomeric repeats. Cell Cycle, 2012. 11: 3036-44.

Hwang, H., Buncher, N., Opresko, P.L.,  Myong, S. Telomeric tail dynamics and sliding clamp activity of POT1-TTP1. Structure, 2012. 20: 1872-80.

Adler, N., Pantell, K., O’Donovan, A., Blackburn, E., Cawthon, R., Koster, A., Opresko, P., Newman, A., Harris, T.B., Epel, E. Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.  Brain Behav Immun., 2013. 27: 15-21.