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Department of Environmental and Occupational Health

Patricia Opresko - Publications (past 5 years)


Sanders JL, Iannaccone A, Boudreau RM, Conley YP, Opresko PL, Hsueh WC, Cummings SR, Cawthon RM, Harris TB, Nalls MA, Kritchevsky SB, Newman AB; for the Health ABC Study. The Association of Cataract With Leukocyte Telomere Length in Older Adults: Defining a New Marker of Aging. J Gerontol A Biol Sci Med Sci. 2011 Jun;66A(6):639-645. Epub 2011 Mar 7. PMID:21382885

O'Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES; for the Health Aging and Body Composition Study. Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study. PLoS One. 2011;6(5):e19687. Epub 2011 May 13. PMID: 21602933

Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus. 2011 Nov-Dec;2(6):570-9. Epub 2011 Nov 1. PMID: 22127259

Miller A, Balakrishnan L, Buncher NA, Opresko PL, Bambara RA. Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro. Cell Cycle. 2012 Mar 1;11(5). PMID: 22336916

Damerla, R.R., Knickelein, K.E., Strutt, S., Liu, F.-J., Wang, H., Opresko, P.L. The Werner Syndrome protein suppresses the formation of large deletions during the replication of human telomeric repeats. Cell Cycle, 2012. 11: 3036-44.

Hwang, H., Buncher, N., Opresko, P.L.,  Myong, S. Telomeric tail dynamics and sliding clamp activity of POT1-TTP1. Structure, 2012. 20: 1872-80.

Adler, N., Pantell, K., O’Donovan, A., Blackburn, E., Cawthon, R., Koster, A., Opresko, P., Newman, A., Harris, T.B., Epel, E. Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.  Brain Behav Immun., 2013. 27: 15-21.

Lormand, J., Buncher, N., Murphy, C.T., Kaur, P., Lee, M.Y., Burgers, P., Wang, H., Kunkel, T.A., and Opresko, P.L. DNA Polymerase d Stalls on Telomeric Lagging Strand Templates Independently from G-quadruplex formation. Nucleic Acids Research, 2013. 41: 10323-33

Hong, W., Lin, J., Countryman, P., Buncher, N., Parminder, K., Longjiang, E., Gibson, G., You, C., Watkins, S., Jacob, P., Opresko, P., and Kad, N. TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres. Nucleic Acids Research, 2014. 42: 2493-504

Hwang, H., Kreig, A., Calvert, J., Lormand, J., Kwon, Y., Delay, J.M., Sung, P., Opresko, P.L., Myong, S. Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. Structure, 2014. 22: 842-53. PMID: 24836024; PMCID: PMC4067947

Lin, J., Countryman, P., Buncher, N., Kaur, P., E., L., Zhang, Y., Gibson, G., You, C., Watkins, S.C., Piehler, J., Opresko, P.L., Kad, N.M., and Wang, H. TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres. Nucleic Acids Research, 2014. 42: 2493-504. PMID: 24271387; PMCID: PMC3936710

Hwang, H., Opresko, P.L., and Myong, S. Single-molecule real-time detection of telomerase extension activity. Scientific Reports, 2014, 12: 7345-54. PMID: 25263700; PMCID: PMC41788293

Pham, H.H., Murphy, C.T., Sureshkumar, G., Ly, D.H., Opresko, P.L., and Armitage, B.A. Cooperative Hybridization of GammaPNA Miniprobes to a Repeating Sequence Motif and Application to Telomere Analysis. Organic and Biomolecular Chemistry, 2014. 12: 7345-54. PMID: 25115693; PMCID: PMC4162129

Murphy, C.T., Gupta, A., Armitage, B.A., and Opresko, P.L. Hybridization of G-quadruplex forming peptide nucleic acids to guanine rich DNA templates inhibits DNA polymerase η extension. Biochemistry, 2014. 53: 5315-22; PMID: 25068499

Pope-Varsalona, H., Liu, F.-J., Guzik, L., and Opresko, P.L. Polymerase h suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Research, 2014. 42: 13096-109.  PMID:25355508; PMCID: PMC4245935

Parikh, D., Fouquerel, E., Murphy, C.T., Wang, H., and Opresko, P.L. Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproduct. Nature Communications, 2015. 6:8214. PMID:26351258; PMCID:PMC4566151

Kaur, K., Wu, D., Lin, J., Countryman, P., Bradford, K.C., Erie, D.A., Riehn, R., Opresko, P.L., and Wang, H. Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2. Scientific Reports, 2016. 6:20513. PMID: 26856421; PMCID: PMC4746636

Lee, S., Opresko, P., Pappo, A., Kirkwood, J.M., and Bahrami, A. Association of TERT promoter mutations with telomerase expression in melanoma. Pigment Cell Melanoma Research, 2016. 29: 391-3. PMID: 26928778

Lin, J., Countryman, P., Chen, H., Pan, H., Fan, Y., Jiang, Y., Kaur, P., Wang, M., Gurgel, G., You, C., Piehler, J., Kad, N., Riehn, R., Opresko, P., Smith, S., Tao, Y., and Wang, H. Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. Nucleic Acids Research, in press

Tippana, R., Hwang, H., Opresko, P.L., Bohr, V.A., and Myong, S. Single molecule imaging reveals a common mechanism shared by G-quadruplex resolving helicases. PNAS, 2016. 113: 8448-53. PMID: 27407146.  PMCID: PMC4968719

Garcia-Exposito, L*., Bournique, E.*, Bergoglio, V.*, Bose, A., Barroso-Gonzalez, J.-B., Zhang, S., Roncaioli, J.L., Lee, M.Y., Wallace, C.T., Watkins, S.C., Opresko, P.L., Hoffmann, J.-S., and O’Sullivan, R.J. Proteomic profiling reveals a specific role for translesion DNA polymerase eta in the alternative lengthening of telomeres.  Cell Reports, 2016. 17: 1858-1871. PMID 27829156. * these authors contributed equally

Fouquerel, E., Lormand, J.*, Bose, A.*, Lee, H.-T., Kim, G.S., Li, J., Sobol, R.W., Freudenthal, B.D., Myong, S., and Opresko, P.L. Oxidative guanine base damage regulates human telomerase activity. Nature Structural & Molecular Biology, 2016. 23: 1092-1100. PMID 27820808. PMCID: PMC5140714


Patricia Opresko - Review Articles (past 5 years)


Lin, J., Kaur, P., Countryman, P., Opresko, P.L., Wang, H. Unraveling secrets of telomeres: One molecule at a time. DNA Repair. 2014.  20: 142-53. PMID: 24569170

Croteau, D.L., Popuri, V., Opresko, P.L., Bohr, V.A. Human RecQ Helicases in DNA Repair, Recombination and Replication. Annu Rev Biochem. 2014. 83: 519-52. PMID: 24606147

Opresko, P.L*, Shay, J.W*. Telomere-Associated Aging Disorders. Ageing Research Reviews. 2017. 33: 52-66. PMID: 27215853.  *Co-corresponding authors

Fouquerel, E., Parikh, D., Opresko, P. DNA damage processing at telomeres: The ends justify the means. DNA Repair special issue. 2016. 44:159-68. PMID: 2723313

Fouquerel, E., Opresko, P. Convergence of the Nobel fields of telomere biology and DNA Repair. Photochemistry and Photobiology. 2017. 93: 229-237.  PMID: 27861975. PMCID: PMC5315637