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Patricia Opresko - Publications (past 5 years)

Harrigan, J.A., P.L. Opresko, C. von Kobbe, P.S. Kedar, R. Prasad, S.A. Wilson, and V.A. Bohr. (2003) The Werner syndrome protein stimulates DNA polymerase b strand displacement synthesis via its helicase activity. J. Biol. Chem, 278, 22686-22695. Abstract

Cheng, W.-H., C. von Kobbe, P. L. Opresko, J. Ren, D. Kufe, and V.A. Bohr. (2003) Werner Syndrome protein phosphorylation by Abl tyrosine kinase regulates its activity. Mol. Cell. Biol., 23, 6385-6395. PMID: 12944467

Laine, J.-P.*, P.L. Opresko*, F.E. Indig, J.A. Harrigan, C. von Kobbe, and V.A.Bohr. (2003) Werner protein stimulates topoisomerase I DNA relaxation activity. Cancer Research, 63, 7136-7146. * authors contributed equally. PMID: 14612507

von Kobbe, C., J.A. Harrigan, A. May, P.L. Opresko, L. Dawut, W.H. Cheng, and V.A. Bohr. (2003) A central role for the WRN/PARP-1 complex in the poly (ADP-Ribosyl)lation pathway after DNA damage. Mol. Cell. Biol., 23, 8601-8613. PMID: 14612404

Cheng W.H., P.L. Opresko, C. von Kobbe, L.M. Arthur, K. Komatsu, M.M. Seidman, J.P. Carney, and V.A. Bohr. (2004). Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J. Biol. Chem., 279, 21169-21176. PMID: 15026416

Opresko, P.L., M. Otterlei, J. Graakjær, P. Bruheim, L. Dawut, S. Kølvraa, A. May, M.M. Seidman and V.A. Bohr. (2004). The Werner syndrome helicase and exonuclease cooperate to resolve D-loop structures at telomeric ends and in a manner regulated by TRF1 and TRF2. Molecular Cell, 14, 763-774. PMID: 15200954

Opresko, P.L., J. Fan, S. Danzy, D.M. Wilson III, and V.A. Bohr. (2005). Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Research, 33, 1230-9. PMID: 15731343

Opresko, P.L., P.A. Mason, E.R. Podell, M. Lei, I.D. Hickson, T.R. Cech, and V.A. Bohr. (2005) POT1 Stimulates RecQ Helicases WRN and BLM to Unwind Telomeric DNA Substrates. J. Biol. Chem., 280, 32069-80. PMID: 16030011

Muftuoglu, M., Wong, H. K., Imam, S., Wilson, D.M. III, Bohr, V.A. and Opresko, P.L. Telomere Repeat Binding Factor 2 Interacts with Base Excision Repair Proteins and Stimulates DNA Synthesis by DNA Polymerase ß. Cancer Research. 2006. 66: 113-124. Abstract

Harrigan, J.A., Wilson, D.M., Prasad, R., Opresko, P.L., Beck, G., May, A., Wilson, S.H. and Bohr, V.A. The Werner syndrome protein cooperates with DNA polymerase ß during base excision repair. Nucleic Acids Research. 2006. 34: 745-754. PMID: 16449207

Zhang, P., Furikawa, K., Opresko, P.L., Xu, X., Bohr, V.A. and Mattson, M.P. TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. Journal Neurochemistry. 2006. 97: 567-581. Abstract

Cheng, W.H ., Kusumoto, R., Opresko, P.L., Sui , X., Huang, S., Nicolette, M.L., Paull, T.T., Campisi, J., Seidman , M.M. and Bohr,V.A. Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Research. 2006. 34: 2751-2760. PMID: 16714450

Opresko, P.L., Calvo, J.P. and von Kobbe, C. Essential role of the Werner syndrome protein in oncogenic proliferation of human caner cells. Mech Ageing Dev. 2007 Jul-Aug;128(7-8):423-36. Epub 2007 May 31. PMID: 1762441

Opresko PL. Telomere ResQue and preservation-Roles for the Werner syndrome protein and other RecQ helicases. Mech Ageing Dev. 2008 Jan-Feb; 129 ( 1-2 ): 79-90 . Epub 2007 Oct 30. PMID: 18054793

Sowd, G., Lei, M., and Opresko, P.L. (2008) Mechanism and Substrate Specificity of Telomeric Protein POT1 Stimulation of the Werner Syndrome Helicase. Accepted in Nucleic Acids Research Jun 25.  PMID: 18583366