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Department of Environmental and Occupational Health

Patricia Opresko - Conferences

Attended Conferences/Workshops

March 2008 Organized and participated in NIEHS ONES advisory committee meeting to monitor and mentor progress
January 2008 Attended GTCbio New Applications in Aging Research Conference, San Diego, CA
August 2007 Invited to attend 2007 Biology of Aging Colloquium, Ellison Medical Foundation, Woods Hole, MA
June 2007 Participated in one week course on Quantitative Fluorescence Microscopy, CBI University of Pittsburgh, MDIBL, Salisbury Cove, Maine
February 2007 Two weeks of training on telomere length measurement assays in Dr. Peter Lansdorp's laboratory, BC Cancer Research Center, Vancouver, Canada
September 2006 4th Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, Morgantown, WV
March 2006 Scientific Management Leadership- 3 day course. Pittsburgh, PA
March 2003 Grantspersonship, Survival Skills and Ethics Workshop
March 1999 Pathobiology of Cancer, AACR Workshop, poster presentation

Abstracts from Attended Conferences/Workshops

  1. Nora, G.J., Sowd, G., and Opresko, P.L. “TRF2 regulates WRN helicase/exonuclease displacement of telomeric Holliday Junctions”.  11th Annual Midwest DNA Repair Symposium. Ann Arbor, MI. May 2009. Student oral presentation.


  2. Wang, H., Nora, G.J., van Houten, B., and Opresko, P.L. “Single-Molecule Studies of G-Quadruplex DNA and POT1 DNA Binding”.  Telomeres and Telomerase, Cold Spring Harbor Laboratory Meeting.  May 2009, CSH, NY.  Postdoctoral fellow poster presentation.


  3. Damerla, R., Jackson, A., Sowd, G., and Opresko, P.L. “Mutagenic Potential of Telomeric DNA”.  Telomeres and Telomerase, Cold Spring Harbor Laboratory Meeting.  May 2009, CSH, NY. PhD student poster presentation.


  4. Liu, F., Barchowsky, A., and Opresko, P.L. “The Werner Syndrome protein functions in repair of Cr(VI) induced stalled DNA replication forks”. The 48th Annual Meeting of the Society of Toxicology. March 2009. Baltimore, MD.  Postdoctoral fellow poster presentation.


  5. Nora, G., Sowd, G., and Opresko, P.L. "Multiplex Analysis of TRF2 Modulation of WRN Helicase/Exonuclease Dissociation of HJ DNA".   Molecular and Clinical Mechanisms in Bloom's Syndrome and Related Disorders.  University of Chicago, IL.  May 2008. Student poster presentation.


  6. Sowd, G., Lei, M. and Opresko, P.L. "Mechanism and Substrate Specificity of Telomeric Protein POT1 Stimulation of the Werner Syndrome Helicase". Molecular and Clinical Mechanisms in Bloom's Syndrome and Related Disorders.  University of Chicago, IL.  May 2008. Staff poster presentation.


  7. Nora, G., Sowd, G., and Opresko, P.L. "Multiplex Analysis of TRF2 modulation of WRN Helicase/Exonuclease Dissociation of HJ DNA". 10th Annual Midwest DNA Repair Symposium. Pittsburgh, PA. May 2008. Student poster presentation


  8. Sowd, G., Lei, M. and Opresko, P.L. "Mechanism and Substrate Specificity of Telomeric Protein POT1 Stimulation of the Werner Syndrome Helicase". 10th Annual Midwest DNA Repair Symposium. Pittsburgh, PA. May 2008. Staff poster presentation


  9. Sowd, G., Lei, M. and Opresko, P.L. "Mechanism and Substrate Specificity of Telomeric Protein POT1 in Promoting the Werner Syndrome Helicase".  Gordon Conference on DNA Damage, Mutations and Cancer, Venture, CA, March 2008. Poster Presentation


  10. Sowd, G., Lei, M. and Opresko, P.L. "Telomeric protein POT1 regulated processing of telomeric ends by the Werner syndrome helicase/exonuclease".  38th Annual Meeting of the Environmental Mutagen Society, Atlanta, GA. October 2007.  Oral presentation.


  11. Sowd, G., Lei, M. and Opresko, P.L. "Roles for the Werner Syndrome Protein in Processing Telomeric Ends". Poster presentation at the FASEB  Research Conference - Helicases and NTP-Drive Nucleic Acid Motors: Structure, Function, Mechanisms and Roles in Human Disease, Indian Wells, CA. June 2007. Poster presentation


  12. Nora, G., Fagerburg, M., Sowd, G., Leuba, S., Opresko, P. "Modulation of Alternative Structures in Telomeric DNA by WRN Helicase and POT1 Binding Protein"  9th Annual Midwest DNA Repair Symposium. Columbus, OH.  May 2007. Student poster presentation.


  13. Damerla, R.R. and Opresko, P.  "Role of Werner Syndrome Protein in Telomere DNA Replication" 9th Annual Midwest DNA Repair Symposium. Columbus, OH. May 2007. Student poster presentation.


  14. Sowd, G., Lei, M., and Opresko P. L. "Telomere Binding Protein POT1 Protects Telomeric End Tails from Processing by Werner Syndrome Helicase/Exonuclease" 9th Annual Midwest DNA Repair Symposium. Columbus, OH. May 2007. poster presentation


  15. Nora, G., Fagerburg, M., Sowd, G., Leuba, S., Opresko, P. "Modulation of Alternative Structures in Telomeric DNA by WRN Helicase and POT1 Binding Protein"  American Physician Scientist Association, Chicago, IL.  April 2007. Student poster presentation.


  16. Opresko, P.L., Muftuoglu, M., Wilson , D.M., and Bohr, V.A. Telomeric Protein TRF2 Stimulations DNA Synthesis by DNA Polymerase ß. Gordon Conference on DNA Damage, Mutations and Cancer, Venture, CA, March 2005.


  17. Opresko, P.L., Muftuoglu, M., Mason, P., Wilson, D.M. III, and Bohr, V.A. RecQ Helicases and DNA Repair Pathways at Telomeric DNA. 9 th International Conference on Environmental Mutagens and 36 th Annual Meeting of the Environmental Mutagen Society, San Francisco, CA, September 2005.


  18. Opresko, P.L., Mason, P., Kusumoto, R., and Bohr, V.A. Roles for RecQ Helicases in Telomere Metabolism. Bloom Syndrome Workshop: Molecular Basis of Genomic Instability, Bethesda MD, April 2005.


  19. Opresko, P.L., Otterlei, M., Fan, J., Kolvraa, S., Wilson , D.M., Seidman, M.M. and Bohr, V.A. The Werner Syndrome Protein and DNA Repair Pathways at Telomeric DNA. 35 th Annual Meeting of the Environmental Mutagen Society, Pittsburgh, PA, October 2004.


  20. Opresko, P.L., Otterlei, M., Graakjær, J., Bruheim, P., Dawut, L., Kølvraa, S., Seidman, M.M. and Bohr, V.A. The Werner syndrome helicase and exonuclease cooperate to dissociate telomeric D-loops in a manner regulated by TRF1 and TRF2. EMBO Workshop/58 th Harden Conference – Telomere and Genome Stability, Cambridge, UK, April 2004.


  21. Opresko, P.L. Roles for the Werner Syndrome Protein in Telomere Metabolism. Baltimore Area Repair Symposium, Baltimore, MD, March 2004.

Invited Lectureships/Seminars - past 5 years

Date
Title of Presentation
Venue
May 2009 Mechanisms for Preserving Chromosomal Ends in Protection Against Premature Aging and Cancer Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, Invited by Dr. Barbara Tudek
April 2009 RPA and POT1 Differentially Modulate WRN Processing of Mobile Telomeric D-loops Telomere and Telomerase, Cold Spring Harbor Laboratory Meetings, CSH, NY
March 2009 Challenges in Telomeric DNA Replication and Repair NIEHS, RTP, NC, Invited by Dr. Thomas Kunkel
March 2009 Mechanisms of Telomeric DNA Loss and Repair 48th Annual Meeting of the Society of Toxicology, Baltimore, MD
February 2009 Werner Syndrome protein processing of recombination repair intermediates at telomeric vs. non-telomeric regions 3rd US/EU Conference on Repair of Endogenous Genome Damage, Galveston, TX
January 2009 Modulation of Telomeric DNA Structure and Function University of Pittsburgh Molecular Biophysics and Structural Biology graduate program: Faculty presentations
November 2008 Telomeric DNA Replication and Repair University of Rochester, invited by Robert Bambara
October 2008 The Werner Syndrome protein in telomere preservation and repair 39th Annual Meeting of the Environmental Mutagen Society, PR.
May 2008 RecQ Helicase Functions at Telomeres Molecular and Clinical Mechanisms in Bloom’s Syndrome and Related Disorders University of Chicago, IL
April 2008 Roles for RecQ helicases in telomere preservation DNA Repair Interest Group Videoconference
University of Pittsburgh, PA Invited by Ken Kraemer and Vilhelm Bohr
December 2007 Mechanism and Substrate Specificity of POT1 Stimulation of Werner Syndrome Helicase AACR special conference in cancer research: The Role of Telomere and Telomerase in Cancer Research.  San Francisco, CA
December 2007 Links between Telomeres, Human Disease and Aging Division of Pulmonary, Allergy, and Critical Care Medicine
University of Pittsburgh School of Medicine Invited by Dr. Bruce Pitt
November 2007 Faculty research presentation Graduate School of Public Health
University of Pittsburgh Board of Visitors Meeting
November 2007 Links between Genomic Instability and Aging Dean's Junior Faculty Seminar Series, GSPH, University of Pittsburgh, PA Invited by Dr. Don Burke
November 2007 Molecular mechanisms of telomere instability associated with aging Gastroenterology Research Seminar Series, UPMC Invited by Dr. Robert Schoen
October 2007 Mechanisms of telomere preservation: links between DNA helicases, premature aging, and cancer Emory University School of Medicine, Department of Pathology Research Seminar, Atlanta, GA Invited by Dr. Jihn Ly
October 2007 Telomeric protein POT1 regulated processing of telomeric ends by the Werner syndrome helicase/exonuclease. 38th Annual Meeting of the Environmental Mutagen Society, Atlanta, GA. Oral presentation.
October 2007 Role of Preserving Chromosome Ends in Protection Against Aging and Cancer Science 2007 University of Pittsburgh, Pittsburgh, PA
May 2007 Roles for the Werner Syndrome Protein in Telomere Preservation 3rd Japan-US DNA Repair Meeting
February 2007 "Mechanisms of telomere preservation: links between DNA helicases, premature aging and cancer" BC Cancer Research Center, Vacouver, Canada
October 2006 "Roles for the Werner syndrome protein in oncogenic proliferation" National Institute on Aging, NIH, Baltimore, MD
October 2006 “Molecular mechanisms of telomeric DNA instability associated with premature aging” Senior Vice Chancellor's Research Seminar Series, University of Pittsburgh
October 2006 “Mechanisms of Telomeric DNA Loss and Repair” National Institute on Environmental Science, NIH, meeting for ONES awardees
September 2006 “Mechanisms of telomere preservation: links between DNA helicases and premature aging” University of Pittsburgh, Molecular Biophysics Seminar

August 2006

Cooperation of the Werner syndrome protein and POT1 in dissociating telomeric DNA substrates Telomere and Genome Stability 2006, International Conference, Villar-sur-Ollon, Switzerland

May 2006

Mechanisms of Telomeric DNA Loss and Repair National Institute of Environmental Health Sciences, NIH, presentation of research proposal

May 2006

 Roles for the Werner Syndrome Protein in Telomere Maintenance Pittsburgh Chromatin Club, mini-symposium, Pittsburgh, PA

May 2006

Cooperation of RecQ Helicases and Telomeric Proteins in Dissociating Telomeric Substrates International Workshop on RecQ Helicases and Other Helicases in Telomere Maintenance and Related Pathways, Lansdowne, VA * co-organizer

January 2006

Werner Syndrome Protein Functions at Telomeres University of Pittsburgh, Human Genetics Seminar series

October 2005

Mechanisms of Telomere Instability Associated with Premature Aging University of Pittsburgh Cancer Institute, Basic Research Seminar Series

June 2005

RecQ Helicases and Telomeric DNA Instability University of Pittsburgh, Department of Molecular Genetics and Biochemistry

March 2005

 

RecQ Helicases and DNA Repair Pathways at Telomeric DNA Keystone Symposia on Genome Instability and Repair, Taos, New Mexico
August 2004;
June 2004 		Links Between Premature Aging and Telomeres 1. University of Pittsburgh Cancer Institute, Pittsburgh, PA;
2. University of Pittsburgh, Department of Environmental and Occupational Health Seminar, Pittsburgh, PA
March 2004; December 2003 Investigating Roles for the Werner Syndrome Protein in Telomere Metabolism 1. University of Maryland Biotechnology Institute, Baltimore, MD;
2. Yale University School of Medicine, Department of Therapeutic Radiology and Genetic, New Haven, CT