YuanPu Di - Publications

Last 5 years

• Jinming Zhao, Reen Wu, and Y.P. Di. Tobacco smoke exposure induces EGFR and ERK1/2 mediated mucin gene activation in lung epithelial cells. (J of Cell Physiology, in revision)



• Jinming Zhao and Y.P. Di. Transcriptional regulation of tobacco smoke exposure induces MUC5AC expression is regulated through Sp1. (submitted to J Biol Chem, in revision)



• Zhao, J, RW Harper, A Barchowsky, YP Di. Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 293:L480-l490, 2007. PMID: 17496060



• Lina Lukinskiene, Sue Reynolds, Chad Steele, Barry Stripp, Jay Kolls, and Y.P. Di.  Functional role of spurt in airway specific epithelial defense against Pseudomonas aeruginosa. (Submitted to Am J Physiol Lung Cell Mol Physiol., in revision)



• Lina Lukinskiene, Joseph pilewski, and Y.P. Di.  CFTR regulates the abnormal secretion of PLUNC proteins in cystic fibrosis patients.(In preparation)



• Jinming Zhao and Y.P. Di. Tobacco smoke induced MUC5AC mucin over-expression is regulated through Sp1. (Submitted to JBC, in revision)



• Yingze Zhang, Annie Pardo, Y.P. Di, Brion S. Maher, Augustine M.K. Choi, Moises Selman, and Naftali Kaminski.  Evidence for gene environment interaction in HNF-3 mediated MMP-7 induction in idiopathic pulmonary fibrosis (submitted to JBC, in revision)



• Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells. 2008 May;26(5):1337-46. Epub 2008 Mar 20. PMID: 18356571



• Lu, Chu, Beth Kokahnen, and Y.P. Di., Expression and function of PLUNC family proteins in human oral cavity. (In preparation)



• Y.P. Di.1*†,Yi Lu2*, Qiuyan Chen2,3, Hongwei Rao4, Beth A. Kahkonen1, Jie Fan5, Ken Patrene2, Timothy J. Titchner1, Escara-Wilke June6,   Chunyan Yu6, Evan T. Keller6, G. David Roodman2, and Jian Zhang2†. Smoking impairs bone remodeling. (to be submitted to J of Exp Med)  



• Daniela Volonte, Beth Kahkonen, Steven Shapiro S, Y.P. Di. and Ferruccio Galbiati. Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem, 284(9): 5462-5466, February 27, 2009. Article



• Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD.  Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45. Epub 2009 Aug 6.  PMID: 19661247



• Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Dopico Jr. RA, Di YP, Knoell DL, Barchowsky A, Leikauf GD. Endothelial Dysfunction and Claudin 5 Regulation during Acrolein-induced Lung Injury. Am J Respir Cell Mol Biol. 2011 Apr;44(4):483-90. Epub 2010 Jun 4. PubMed PMID: 20525806



• Leikauf G.D., Pope-Varsalona H., Concel V.J., Liu P., Bein K., Brant K.A., Dopico R.A.Jr, Di Y.P., Jang A-S., Dietsch M., Medvedovic M., Li Q., Vuga L.J., Kaminski N., You M., Prows D.R. Functional genomics of chlorine-induced acute lung injury in mice. Proc. Am. Thorac. Soc. 2010 Jul;7(4):294-6. PubMed PMID: 20601635



• Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J Exp Med. 2010 Nov 22;207(12):2595-607. Epub 2010 Oct 25. PMID: 20975041



• Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA, Dietsch M, Pope-Varsalona H, Dopico Jr RA, Di YP, Li Q, Vuga LJ, Medvedovic M, Kaminski N, You M, Prows DR. Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1. Am J Respir Crit Care Med. 2011 Feb 4. PubMed PMID: 21297076



• Vo N, Wang D, Sowa G, Witt W, Ngo K, Coelho P, Bedison R, Byer B, Studer R, Lee J, Di YP, Kang J. Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus cell metabolism. J Orthop Res. 2011 Mar 29. doi: 10.1002/jor.21417. PMID:21448984



• Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW. SPLUNC1 Promotes Lung Innate Defense Against Mycoplasma pneumoniae Infection in Mice. Am J Pathol. 2011 May;178(5):2159-67. PMID:21514430



• Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP. Antimicrobial Activity of PLUNC Protects against Pseudomonas aeruginosa Infection. J Immunol. 2011 Jul 1;187(1):382-90. Epub 2011 Jun 1. PubMed PMID: 21632717: PubMed Central PMCID: PMC3119743.



• P. Keohavong, B. Kahkonon, E. Kinchington, J. Yin, X. Liu, J. Jin, J. M. Siegfried and Y.P. Di. K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation. Anticancer Res. 2011 Sep;31(9):2877-82. PMID:21868532



• Y.P. Di. Functional roles of SPLUNC1 in innate immune response against gram-negative bacteria. Biochem Soc Trans. 2011 Aug 1;39(4):1051-5. PubMed PMID: 21787346



• Y. Zhang, R Birru, and Y.P. Di. Analysis of clinical and biological samples using microsphere based multiplexing Luminex system. Methods in Molecular Biology, Humana Press, Springer publisher (in press)



• Y.P. Di. Assessment of pathological and physiological changes in mouse lung through bronchoalveolar lavage. Methods in Molecular Biology, Humana Press, Springer publisher (in press)



• Tao S, Zhu L, Lee P, Lee WM, Knox K, Chen J, Di YP, Chen Y. Negative Control of TLR3 Signaling by TICAM1 Downregulation. Am J Respir Cell Mol Biol. 2011 Dec 28. PMID:22205631



• Richards T, Park C, Chen Y, Gibson KF, Di YP, Pardo A, Watkins SC, Choi AM, Selman M, Pilewski JM, Kaminski N, Zhang Y. Allele Specific Transactivation of Matrix Metalloproteinase 7 by FOXA2 and Correlation with Plasma Levels in Idiopathic Pulmonary Fibrosis. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 20. PMID: 22268124



• Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP. Integrative Assessment of Chlorine-induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2012 Mar 23. PubMed PMID: 22447970



• Birru R, Kahkonon B, Di YP. Chronic Inflammation in the Pathogenesis of COPD and Lung Cancer. Proc Am Thorac Soc. 2012 May;9(2):81. No abstract available. PMID: 22550252

Symposia and Abstracts - past 5 years

Jinming Zhao and Y.P. Di. The regulation of tobacco smoke exposure induced JNK phosphorylation in GSTPi function. International Conference for American Thoracic Society. San Diego, U.S.A. May 18-23, 2007.

Y.P. Di. and J Kolls. Characterization of innate immuno-regulatory function of PLUNC in Cystic Fibrosis. Gordon Research Conference in Biology of Acute Respiratory Infection. Ventura, U.S.A. March 9-14, 2008.

Yang Liu*, Maria Ines Barría*, Eric Lagasse, Y.P. Peter Di. Establishment of a distal bronchiolar airway epithelial cell culture and the identification of candidate surface markers. NIH Stem Cell Meeting. Chicago, U.S.A. November 6-7, 2008. (*Equal Contribution).

Y.P. Di. Functional characterization of PLUNC in airway innate immunity. Gordon Research Conference in Antimicrobial Peptides. Ventura, U.S.A. March 1-6, 2009.

Y.P. Di. Synergistic lung tumorigenesis by smoke carcinogen and inflammation. Molecular origins of lung cancer: Prospects for personalized prevention and therapy. Coronado, U.S.A. January 11-14, 2010.

Yang Liu, Yvonne, Chan, Paul McCray, and Y.P. Di. Airway PLUNC and Respiratory Infection. Gordon Research Conference in Biology of Acute Respiratory Infection. Ventura, U.S.A. March 21-26, 2010.

Marissa E. Di, Beth Kahkonon, Edwina Kingchiton, Phouthone Keohavong, and Y.P. Di. Chronic inflammation promotes tobacco smoke carcinogen induced lung tumor formation. Annual meeting of American Association for Cancer Research, Washington DC, U.S.A. April 17-21, 2010.

Phouthone Keohavong, Beth Kahkonon, Edwina Kingchiton, Jinling Yin, Jide Jin, Jill M. Siegfried, and Y.P. Di. Pulmonary inflammation and lung tumorigenesis in mice. 101st annual meeting of American Association for Cancer Research, Washington DC, U.S.A. April 17-21, 2010.

Yang Liu, Joe Latoche, Joe Pilewski, and Y.P. Di. Differential expression of SPLUNC1 and LPLUNC1 in lungs of healthy human subjects and COPD patients. International Conference for American Thoracic Society. New Orleans, U.S.A. May 14-19, 2010.

Invited Seminars - past 5 years

Inflammation and Tissue Remodeling in Cystic Fibrosis. Department of Cell and Physiology, University of Pittsburgh, January 16, 2007.

Regulation of cigarette smoke induced mucus hypersecretion in airway epithelium. "Grand Rounds" conference, Division of Newborn Medicine, Magee-Women's Hospital, January 18, 2007.

Transcriptional regulation of cigarette smoke-induced MUC5AC expression in airway epithelium. Gordon Research Conference, “ CILIA, MUCUS & MUCOCILIARY INTERACTIONS” Ventura, CA, February 6, 2007.

Environmental Exposure, Lung Disease and Public Health. Dean's Junior Faculty Seminar. Graduate School of Public Health, University of Pittsburgh. February 19, 2007.

PLUNC protein family and innate immunity in pulmonary diseases. Research Conference, Division of Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh. April 2, 2007.

PLUNC, Innate Immunity, and Cystic Fibrosis. The Center for Comparative Respiratory Diseases, University of California, Davis. April 13, 2007.

Differential expression of PLUNC in cystic fibrosis. Cystic Fibrosis Center, University of Pittsburgh, January 8, 2008.

Environmental tobacco smoke exposure and health effect:  What do we learn from mouse models?  The Hamner Institutes for Health Sciences, February 28, 2008.

Functional Characterization of PLUNC in Airway Epithelium. Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT, November 20, 2008.

PLUNC proteins and innate immunity in Cystic Fibrosis. Department of Cell and Physiology, University of Pittsburgh, March 27, 2009.

Environmental Exposure, Innate Immunity, and Lung Disease. Department of Environmental and Occupational Health, University of Pittsburgh, September 10, 2009.

Synergistic Multiplication of Tumorigenesis by Cigarette Smoke Carcinogen and Inflammation. Graduate School of Public Health. University of Pittsburgh, October 20, 2009.

Lung Stem Cells and Tissue Remodeling in Cystic Fibrosis. Cystic Fibrosis Center, University of Pittsburgh, March 2, 2010.