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Petr Pancoska, PhD. |
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Center for clinical pharmacology
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Entromics is the complete theory of physical genomics. The etymology of this discipline name comes from its objective – to derive a quantitative characterization of the energy cost for the assembly of the genome using physical arguments. We study this novel entropy distribution along the genome, which leads us to the name “entromics”. All physical principles of entromics are derived from the single DNA or RNA sequence. There is no alignment or probabilistic argument in this derivation; all steps are deterministic or derived directly by exact mathematical operations from general physical principles, exactly established and validated elsewhere in science. We therefore call entromics the theoretical foundation of individual genomics. Entromics' novel contribution is a correlation between the specially defined entropy of a DNA sequence assembly and the functionality of that sequence in the non-coding as well as coding regions. This contribution is based on fundamental mathematical and physical analysis of energy aspects of genome assembly. |
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Dr. Pancoska is a Research Associate Professor of Medicine, whose main research interests are on applications of mathematical methods in molecular biology and medicine. His research expertise is on the development of novel interdisciplinary applications of advanced computational methodologies. He is a member of the pharmacogenetic team at the Center for Clinical Pharmacology. He earned his PhD. degree in physics at the Charles University Prague, Czech Republic. He also serves as the Board Member of the international Center for Discrete Mathematics, Theoretical Computer Science and Applications (DIMATIA), Charles University Prague. |
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University of Pittsburgh, Center for Clinical Pharmacology 100 Technology Drive, Suite 450 Pittsburgh, PA 15219
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Phone: 412-624-8943 Fax: 412-648-1837 E-mail: pep9@pitt.edu
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University of Pittsburgh |
