Name: Guoguang yang
Title:





Educational Background:

MSRC Research Group:
Mechanobiology

Lab Contact Info:
Musculoskeletal Research Center
405 Center for Bioengineering
300 Technology Drive
Pittsburgh, PA 15219
Phone: 412-648-1943
Fax: 412-648-2001
guy2@pitt.edu

Research Interests:
Current project:
Tissue engineering on bioscaffolds enhance healing tendon and ligament in a rabbit model.
  1. Culture rabbit ACL, MCL, patella tendon and bone marrow derived cells
  2. Cells response on an aligned bio-scaffold (SIS).
  3. Cells response on SIS gel.
  4. SALS, RNA and protein, ECM quantification and analysis.
The effect of mechanical loading on the growth and inflammation factor expressions, collagen synthesis in the extracellular matrix, and the differentiation of human tendon fibroblasts.
  1. Cells culture from tendon samples.
  2. Perform controlled mechanical cyclic stretching.
  3. RNA, DNA, and protein quantification and analysis.
Tissue engineering research on the regeneration and repair of bone cells and chondricytes.
  1. Cell culture from fresh bone and cartilage tissues. Separation of stem cells from bone marrow.
  2. Synthesis of scaffold for tissue engineering use.
  3. Property tests for synthesized polymer materials.
  4. In vitro cell culture on polymer scaffolds. In vivo surgery experiment with polymer scaffolds.

Publication:
  1. Alejandro Almarza, Guoguang Yang, Savio L-Y Woo, Tan Nguten, Steven D. Abramowich. Positive changes in Response of Bone Marrow Derived Cells to Culture on an Aligned Bioscaffold. Paper was submitted to Journal of Biomechanics on Dec. 2007.
  2. Guoguang Yang, Hee-Jeong Im, James H-C Wang. Repetitive Mechanical Stretching Modulates IL-1 Induced COX-2, MMP-1 Expression, and PGE2 Production in Human Patellar Tendon Fibroblasts. Gene 363 (2005) 166-172.
  3. James H-C Wang, Guoguang Yang , Zhaozhhu Li. Controlling Cell Responses to Cyclic Mechanical Stretching. Annals of Journal of Biomed Engineering , Vol.33 March 2005 pp.337~342.
  4. Guoguang Yang, Richard C. Crawford, James H-C. Wang. Proliferation and collagen production of human patellar tendon fibroblasts in response to cyclic uniaxial stretching in serum-free conditions. Journal of Biomechanics, 37 (2004) 1543-1550.
  5. Qing Yang, Guoguang Yang, Jianying Zhang, Noriyoshi Masuoka, Yun Z. Riffle, Zhigang Wang, Hideo Ebinuma, and Hiroyuki Kodama. Effect of Agkistroden blomhoffi (mamushi) on the proliferation of Human Fibroblasts. Clinical Biochemistry, 37 (2004) 138-145.
  6. Zhaozhu Li, Guoguang Yang, Mustafa Khan, David Stone, Savio L-Y.Woo, James H-C Wang. Inflammatory Response of Human Tendon Fibroblasts to Cyclic Mechanical Stretching. American Journal of Sports Medicine, 32:2 (2004) 435-440.
  7. James H-C. Wang, Guoguang Yang, Zhaozhu Li, Wei Shen. Fibroblast responses to cyclic mechanical stretching depend on cell orientation to the stretching direction. Journal of Biomechanics, 37 (2004) 573-576.
  8. James H-C Wang, Zhaozhu Li, Guoguang Yang, and Mustafa Khan. Repetitively Stretched Tendon Fibroblasts Produce Inflammatory Mediators. Clinical Orthopaedics & Related Research, Paper in the press, Feb. 2004.
  9. Guoguang Yang, Richard C. Crawford, James H-C Wang. Stretching-induced Collagen Type I Synthesis in Human Tendon Fibroblasts is mediated by TGF- 1. ASME International Mechanical Engineering Congress. Paper Number IMECE 2003-43047 (Oct. 2003).
  10. Wang H-C. James, Jia F, Yang GG, Yang SH, Stone D, Woo SL-Y. An in vitro model study of the effect of cyclic mechanical stretching on the production of prostaglandin E2 by human tendon fibroblasts. Conn. Tissue Res., 44:3-4 (2003) 128-133.
  11. Jianyang Zhang, Eric J. Beckman, Jing Hu, Guoguang Yang, Sudha Agarwal and Jeffrey O. Hollinger. Synthesis, Biodegradability, and Biocompatibility of Lysine Diisocyanate-Glucose Polymers. Tissue Engineering, 8:5 (2002) 771-785
  12. Qing Yang, Stephen M. Populo, Jianying Zhang, Guoguang Yang, Hiroyuki Kodama. Effect of Angelica Sinensis on the Proliferation of human Bone Cells. Clinica Chimica Acta 324 (2002) 89-97

Recent Abstracts:
  1. Alejandro Almarza, Guoguang Yang, Tan Nguten, Steven D. Abramowich, and +Savio L-Y Woo. Bone Marrow Derived Cells Express more Collagen when Seeded on Elongated Small Intestine Submucosa. Presentation in the Orthopedic Tissue Engineering session, Chicago, IL October 14 2006.
  2. Guoguang Yang, Alejandro Almarza, Tan Nguten, David Shin, Steven D. Abramowich, and +Savio L-Y Woo. Cells Seeded on Porcine Small Intestine Submucosa under Constant Elongation Align along the Improved Collagen Fiber Orientation. International Symposium Ligaments & Tendons - VI, Chicago, IL March 18, 2006
  3. Guoguang Yang, James H-C Wang. Cyclic Mechanical Stretching Regulates IL-1? induced Cox-2 expression in Human Patella Tendon Fibroblasts. 51st Annual Meeting of Orthopaedic Research Society, Washington, D.C. March 2005
  4. Guoguang Yang, James H-C Wang. Cyclic mechanical stretching modulates Cox-2 expression and PGE2 production in Human Tendon Fibroblasts. Midwest Connective Tissue Workshop-POSTER Cleveland, OH Sep. 2004
  5. Guoguang Yang, Richard C. Crawford, James H-C Wang. Stretching-induced Collagen Type I Synthesis in Human Tendon Fibroblasts is mediated by TGF- 1. ASME International Mechanical Engineering Congress Winter Session, Washington D.C., Nov. 2003
  6. Zhaozhu Li, Guoguang Yang, Mustafa Khan, David Stone, Savio L-Y. Woo, James H-C Wang. A Study of the Molecular Mechanisms for the Development of Tendinopathy Using a Novel In Vitro Model. Midwest Connective Tissue Workshop, Chicago, Oct. 2002
  7. Wang H-C. James, Yang Guoguang. Cyclic Stretching of Human Tendon Fibroblasts Increased PGE2 Production but Decreased Inflammatory Gene Expression: Implications for Tendon Pathophysiology. 2002
  8. Wang, JH-C, Yang, GG., Yang, SH., Salari, N., Civic, B., Stone, D., and Woo, SL-Y. Prostaglandin regulation and its effect on proliferation and collagen synthesis in the human tendon fibroblasts. Midwest Connective Tissue Conference, Oct. 2001
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