International Symposium
Ligaments & Tendons - ISL&T-XVII

April 21, 2018

Hangzhou The New Hotel
No 58 Beishan Road
Hangzhou, Zhejiang
China 310007

General Information
Preliminary Program
Symposium Awards
Instructions for Presenters
Previous Meetings

Preliminary Program


Download the schedule in PDF Format here

Podium Sessions

Time Topics Presenting Author
7:30 Registration and Light Breakfast  
8:00 Welcome

Hongwei Ouyang, M.D., Ph.D.
Savio L-Y. Woo, Ph.D., D.Sc., D.Eng.

8:15 Clinical Lecture: Re-recognition of Synthetics Ligament for ACL Reconstruction: Chinese Experience Shiyi Chen, M.D., Ph.D
8:25 Discussion  

Podium Session I: Tendon & Ligament Biomechanics

Shiyi Chen, M.D., Ph.D.
Matthew Fisher, Ph.D.

8:30 Keynote Lecture: Orientation, Size and Function of the Anterior Cruciate Ligament During Skeletal Growth: Results From a Porcine Model Matthew Fisher, Ph.D.
8:40 Discussion  


Biomechanical Augmentation of Tendon Graft Healing in Anterior Cruciate Ligament Reconstruction Using a Silk Based Osteoconductive Sheath Thomas Teh, Ph.D.
8:50 Development of Functional Assessments by Gait and Open Field Analysis in a Rat Model of Rotator Cuff Tendon Repair Yang Liu, M.Surg.
8:55 MRI Measurement on Water Content in Patellar Tendon:  Relationship with Tendon Integrity and Stiffness Siu Ngor Fu, Ph.D.
9:00 Finite Element Analysis of Joint Stability and ACL Load Following Mechanical Augmentation for Goat ACL Healing Huizhi Wang, B.S.
9:05 Anterior Cruciate Ligament Reconstruction Revision Preoperative Planning, Intra Operative Findings and Postoperative Analysis Christos D. Papageorgiou, M.D., Ph.D.
9:10 Discussion  
9:25 Coffee Break/ Poster Session I (#1-12)  
  Podium Session II: Tendon & Ligament Biology Moderators:
Albert J. Banes, Ph.D.
Minghao Zheng, M.D., Ph.D.
9:55 Apoptotic Bodies From Tenocytes Enhance the Proliferation and Migration of Tenocytes and Bone Marrow Stromal Cells in a Canine Tendon In Vitro Model

Chenhui Dong, Ph.D., M.D.

10:00 TGFβ1 Induces a Contractile CD146+ Phenotype of Human Annulus Fibrosus Cells Showing Affinity to a Collagen Gel

Zhen Li, Ph.D.

10:05 Neural Crest-Derived Cells Migrate From Nerve and Participate in Achilles Tendon Remodeling Kang Xu, Ph.D.
10:10 Impaired Function of Tendon-Derived Stem Cells Isolated From Patellar Tendon in Streptozotocin-Induced Type I Diabetes Mellitus Rat Model: Implications for the Cellular Mechanism of the Diabetic Tendon Disorder

Shi Liu, M.D., M.S.

10:15 Discussion  
10:30 Anatomical Heterogeneity of Canine Digit Annular Ligament

Yu-Long Sun, Ph.D.

10:35 Toxicity of Tranexamic Acid to Human Tendon Tissue and Tenocytes In Vitro

Michael McLean, MbChb, Bmsc

10:40 miR-378 Inhibits Extracellular Matrix Production During Tendon Repair in Mouse Model

Yang Liu, Ph.D.

10:45 Discussion  
  Podium Session III: ACL and Tendon-to-Bone Healing I Moderators:
Kai-Ming Chan, M.D., Ph.D.
Kanglai Tang, M.D., Ph.D.
11:00 Keynote Lecture: Current Strategy in the Treatment of Tendinopathy

Kanglai Tang, M.D., Ph.D.

11:10 A Novel KGN-Releasing Polymer for Regeneration of Wounded Tendon-Bone Junction Jianying Zhang, Ph.D.
11:15 Autologous Adipose-Derived Mesenchymal Stem Cells-Sheets Sandwiched by a Book-Type Acellular Fibrocartilaginous Matrix Scaffold Enhances Tendon-Bone Healing

Can Chen, B.S.

11:20 Flexible Bipolar Nanofibrous Membranes for Improving Gradient Microstructure in Tendon-to-Bone Healing Xiaoxi Li, B.S.
11:25 Tendon Stem Cells Transduced with SOX9 Improve Tendon-to Bone Healing in a Rat Model Youxing Shi, Ph.D.


11:45 Effect of PET Graft Coated with Silk Fibroin via EDC/NHS Crosslink on Graft-Bone Healing in ACL Reconstruction

Dandan Sheng, M.Med.

11:50 The Effect of 58S Bioactive Glass Coating on Polyethylene Terephthalates in Graft-Bone Healing Yang Wu, M.D.
11:55 Development of Artificial Collagen Ligament (ACL®) for Anterior Cruciate Ligament Reconstruction Minghao Zheng, M.D., Ph.D.
12:00 Discussion  
12:15 Lunch (Group Photo and Poster Viewing)  
  Podium Session IV: Tendon Repair and Regeneration

James Goh, Ph.D.
Yu-long Sun, Ph.D.

13:30 Keynote Lecture: Biological and Functional Treatment of the PCL Injury Ramon Cugat, M.D., Ph.D.
13:40 Discussion  
13:45 Savio L-Y Woo Young Researcher Award - Biology Research Category:Novel Tendon-Derived Stem Cell Sheet Secures Functional Repair of Torn Rotator Cuff Through TGF-β3 and IGF-1 Signaling Jiankun Xu, Ph.D.
13:55 Discussion  
14:00 Thermo-Responsive Elastomer Layers for Cell Sheet Engineering with Dynamic Cell Culture In Vitro

Gen Wang, Ph.D.

14:05 3D Printed Knitted Scaffold for Tunable Delivery of miR210 for Tendon Regeneration

Yanjie Zhang, B.S.

14:10 Discussion  
14:20 IGelatin-Grafted Poly(L-lactide) Electrospun Fibrous Membranes for Healing Improvement After Rotator Cuff Repair

Wenguo Cui, Ph.D.

14:25 The Mechanical Property and Microstructure of Scaffolds Regulate Differentiation of Annulus Fibrosus-Derived Stem Cells

Genglei Chu, Ph.D.

14:30 The Effect of Bone Marrow Stem Cells-Seeded Polyethylene Terephthalate Scaffold on Repair and Regeneration of Rabbit Achilles Tendon

Genglei Chu, Ph.D.

14:35 Discussion  
  Podium Session V: Tendon-Related Stem Cell Biology Moderator:
Sai Chuen Bruma Fu, Ph.D.
Yiting Zhou, Ph.D.
14:50 Stem Cells Isolated From Sheath and Core of Rabbit Anterior Cruciate Ligament (ACL) Exhibit Differential Biological Properties Biao Chen, M.D., Ph.D.
14:55 Tenogenic Differentiation of Human Mesenchymal Stem Cells on Highly Aligned Ultrafine PLLA Fibers Functionalized by Type-I Collagen and Chondroitin Sulfate

Huihua Yuan, Ph.D.

15:00 3D Microenvironments Boost Induction of Stemness and Tenogenesis in TSPCs Through RNA Demethylation

Qin Tian, B.S.

15:05 Curcumin Maintains the Phenotype and Promote the Tenogenesis of Tendon Stem/Progenitor Cells in the Pathological Microenvironment of Tendinopathy

Zi Yin, Ph.D.

15:10 Discussion  
15:25 Phenotypic Expansion of Mouse Tendon Stem/Progenitor Cells for Tendon Repair by Small Molecule

Can Zhang, Ph.D.

15:30 Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells

Yiting Zhou, Ph.D

15:35 Fos Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells

Jialin Chen, Ph.D.

15:40 Discussion  
15:55 Coffee Break/Poster Session II (#13-23)  
  Podium Session VI: ACL and Tendon-to-Bone Healing II Moderators:Chunfeng Zhao, M.D.
Gang Li, M.D, Ph.D.
16:25 Surface Modification of VEGF Loaded Silk Fibroin to Improve Biological Performance of UHMWPE via Promoting Angiogenesis

Chengchong Ai, M.Med.

16:30 Intraoperative Irrigation with Magnesium and Vitamin C Solution Reduced Morphological Alterations in Quadriceps Muscle and Improved Graft Healing Following ACL Reconstruction in a Rat Model

Yau-Chuk Cheuk, M.Phil.

16:35 Local Delivery of Controlled-Release Simvastatin to Improve the Biocompatibility of Polyethylene Terephthalate Artificial Ligaments for Reconstruction of the Anterior Cruciate Ligament

Peng Zhang, Ph.D.

16:40 Discussion  
16:55 Ectopic Tissue Engineered Ligament with Silk Collagen Scaffold for ACL Regeneration

Jisheng Ran, M.D.

17:00 The Use of Silk Fibroin Coating to Enhance Intra-Articular Ligamentization of PET Artificial Ligament in Beagle Dog ACL Reconstruction Model

Jia Jiang, M.D.

17:05 Comparison of the Allograft and Autograft After Anatomical Lateral Ankle Ligament Reconstruction Using MRI UTE-T2* Evaluation

Yinghui Hua, M.D., Ph.D.

17:10 Discussion  
17:25 The Mg Interference Screw Developed for Enhancement of the Tendon Graft Healing in ACL Reconstruction Model

Jia-li Wang, Ph.D.

17:30 Effect of bFGF-Loaded Ca5(PO4)2SiO4 Bioceramic on Tendon-to-Bone Healing After Repair of Chronic Rotator Cuff Tear

Song Zhao, M.D.

17:35 Discussion  
17:45 Closing Remarks for ISL&T - XVII  
18:00 Meeting adjourned  
19:00 Banquet and Award Ceremony
Hangzhou The New Hotel

Poster Sessions
Chih-Hwa Chen, M.D., Christos D. Papageorgiou, M.D., Ph.D.,
Hongbin Lu, Ph.D., Bin LI, Ph.D.

Poster Number Title Presenting Author
1 Effects of Vitrification on the Biological Characteristics of Tendon Stem/Progenitor Cells in the Rat Tendon Tissues

Guang-Chun Dai, B.S.

2 A Study on the Hierarchical Collagen Meshwork of Achilles Tendons

Jian-Ping Wu, Ph.D.

3 Injectable Microcryogel Cell Microcarriers for the Repair of Acute Achilles Tendon Rupture in a Rat Model.

Xuan Yang

4 Comparative Study of the Ability of Tendon Stem Cells and Bone-Marrow Stem Cells to Promote the Repair of the Tendon-Bone Interface

Chengsong Yuan


5 Bone Marrow Mesenchymal Stem Cells-Sheets Sandwiched by a Book-Shape Decellularized Tendon Matrix Scaffold for Repair of Achilles Tendon Defect

Meihan Tao, M.S.

6 Bone Marrow Mesenchymal Stem Cells-Sheets Sandwiched by a Book-Shape Decellularized Tendon Matrix Scaffold for Repair of Achilles Tendon Defect

Hongbin Lu, Ph.D.

7 The Effect of Cartilage Fragments on Tendon-Bone Integration After Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Controlled Study

Chi Zhang, Ph.D.

8 Biological Augmentation of Tendon to Bone Healing Repair Using bFgF-Loaded Electrospun PLGA Fibrous Membranes

Wei Su, M.D.

9 Biological Augmentation of Rotator Cuff Repair Using bFGF-Loaded Electrospun Poly(lactide-co-glycolide) Fibrous Membranes

Wenxiao Qi, B.S.

10 Achilles Tendon Adaptation During a 12-week Minimalist Running Retraining

Xini Zhang, M.S.

11 Inhibition of Rac1 Activity Prevents Pathological Calcification in Degenerative Tendinopathy

Yangwu Chen, B.S.

12 Surface Modification of Polyethylene Terephthalate Ligament by Hydroxyapatite Plasma Spraying Improves Biocompatibility In Nitro and Osseointegration In Vivo

Siheng Wang, M.D.

13 Regulation of Tendon-Derived Stem Cell Differentiation by the Degenerative Tendon Microenvironment

Chang Liu, M.D.

14 Sparc Regulates Tendon Development

Tao Wang, Ph.D.

15 Aligned Silk-Collagen Scaffold for Functional Massive Rotator Cuff Repair

Jiayun Huang, M.S.

16 Microfluidic Chip System for Decellularized Tendon Based 3D-Biomimetic Scaffolds to Enhance the Bone-Tendon Interface Healing and Its Mechanism

Jingtong Lyu, M.D., Ph.D.

17 The Osteogenesis of Hydroxyapatite and Gelatin Coating on the Polyethylene Terephthalate Artificial Ligament

Dandan Sheng, M.Med.

18 Development of an Assay to Address Potency, Purity and Identity for Autologous Tenocyte Implantation

Minghao Zhang, M.D., Ph.D.

19 Evaluation of the Bone-Ligament and Tendon Insertions Based on Raman Spectrum and Its PCA and CLS Analysis

Yang Wu, M.D.

20 3D Printed Scaffold with Delivery of TGF-β1 miRNA Plasmid for Preventing Flexor Tendon Adhesion Formation

Yinxian Yu, M.D.

21 In vitro Evaluation of Rotator Cuff Repairment with Biocomposite Suture Anchor: Long-Term Degradation Study

Xiao-Yan Cao, B.S.

22 Decellularization of Remolded Rat Gracilis Muscle Flap as a Potential Scaffold for Skeletal Muscle Composite Allotransplantation

Chenhui Dong, Ph.D., M.D.

23 Identification of an Anti-Inflammation Protein, Annexin A1, in TDSCs of Cystic Fibrosis Mice

Yang Liu, Ph.D.