International Symposium
on
Ligaments & Tendons - XII

Friday, February 3, 2012

Hilton Financial District
San Francisco, California


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Program at a Glance

Thematic Keynote Lectures
  • Clinical Session: Dr. Matuo Ochi
  • Session 1: Dr. CB Frank
  • Session 2: Prof. David Butler
  • Session 3: Prof. Louis Soslowsky
  • Session 4: Prof. Patrick Danielson
  • Session 5: Dr. Ronen Shweizer


    Time

    Session

    Chairs

    7:00 – 7:45

    Registration and Light Breakfast

     

    7:45 – 7:55

    Welcome

    Savio L-Y.Woo,Ph.D., D.Sc.,D. Eng.

    7:55 – 8:10

    Welcome

    K.M. Chan, MD

    8:10 – 8:25

    Clinical Talk

    Keynote Lecture: ACL Injury and Tunnel Length for ACL Reconstruction

    Speaker: Matsuo Ochi, MD

    Chair: Ranjan Gupta, MD

    8:25 – 10:26

    Podium Session 1: ACL (Click for detail)

     

    Keynote Lecture: Biology of Healing and Biomechanics after ACL Reconstruction. 

    Speaker: CB Frank, MD

    11 podium presentations

    Mitsuo Ochi, MD,

    Guoan Li, Ph.D.

    10:26 – 10:56

    Break / Poster Session

    16 poster presentations

    Louis Soslowsky, Ph.D.,

    Stavros Thomopoulos, Ph.D.

    10:56 – 12:35

    Podium Session 2: Tendon and Ligament Tissue Engineering

    (Click for detail)

     

    Keynote Lecture: Working Across Model Systems at the Interface between Functional Tissue Engineering and Developmental Biology to Improve Adult Tendon Repair. 

    Speaker: David Butler, Ph.D.

    10 podium presentations

    Helen Lu, Ph.D.,

    PW Ackermann, MD, Ph.D.

    12:35 – 13:35

    Lunch

     

    13:35 – 14:33

    Podium Session 3: Rotator Cuff

    (Click for detail)

     

    Keynote Lecture: Rotator Cuff Tendon Healing in an Animal Model. 

    Speaker: Louis Soslowsky, Ph.D.

    4 podium presentations

    Zong-Ming Li Ph.D.,

    Chih-hwa Chen, MD, Ph.D.

    14:33 – 15:33

    Podium Session 4: Tendinopathy

    (Click for detail)

     

    Keynote Lecture: Biochemical Causes of Tendinopathy. 

    Speaker: Patrik Danielson, MD, Ph.D.

    5 podium presentations

    Braden Fleming, Ph.D.,

    Nicola Maffulli, MD

    15:33 – 16:03

    Break / Poster Session

    15 poster presentations

    Catherine K. Kuo, Ph.D.,

    Wei-Hsiu Hsu, MD

    16:03 – 18:15

    Podium Session 5: Biology and Biomechanics of Tendons and Ligaments

    (Click for detail) 

     

    Keynote Lecture: Regulation of Tendon Elongation by Strain and Scelraxis Dependent Tenocytes Induction.

    Speaker: Ronen Schweize, Ph.D.

    14 podium presentations

    PPY Lui, Ph.D.,

    Christer Rolf, Ph.D.

    18:15 – 18:20

    COA 2012 – ISL&T

    KM Chan, MD

    18:20 – 18:25

    ISL&T 2013, Perugia/Arezzo, Italy

    Giuliano Cerulli, MD

    18:25 – 18:30

    Closing Remarks

    Chih-hwa Chen, MD, Ph.D.

    19:00 – 21:30

    Reception / Banquet
    Far East Cafe
    631 Grant Avenue
    San Francisco, CA 94108     (Google Maps)
    TEL: (415) 982-3245

     




    Preliminary Program

    Time

    Code

    Topics

    Speakers

    7:00

     

    Registration and Light Breakfast

     

    7:45

     

    Welcome

    Savio L-Y. Woo, PhD, DSc, DEng

    7:55

     

    Welcome

    K.M. Chan, MD

    8:10

     

    Clinical Talk

    Chair: Ranjan Gupta, MD

     

     

    ACL injury and tunnel length

    -Transtibial versus far anteromedial portal technique for posterolateral femoral tunnel drilling In anatomic double-bundle anterior cruciate ligament reconstruction

    Mitsuo Ochi, MD

     

     

    Podium Session 1: ACL

    Session Chairs:
    Mitsuo Ochi, MD,
    Guoan Li, Ph.D.

    8:25

     

    Keynote Lecture: Biology of healing and biomechanics after ACL reconstruction

    Cyril Frank, MD

    8:40

    S1-1

    Local Administration of Alendronate Reduced Peri-Tunnel Bone Loss and Promoted Graft-Bone Tunnel Healing in ACL Reconstruction

    Yuk Wa Lee

    8:46

    S1-2

    Effects of Altering Grade on Vertical Ground Reaction Forces and ACL Forces in the Sheep Model

    Rebecca J. Nesbitt

    8:52

    S1-3

    Effect of Combined ACL and Meniscus Injuries on Knee Joint Kinematics

    Guoan Li

    8:58

    S1-4

    Characterization of Inflammation Following ACL Injury

    Carla Haslauer

    9:04

     

    Discussion

     

    9:19

    S1-5

    Biplanar X-ray Derived ACL Excursions during a Jump-Cut Maneuver Associated with ACL Injury

    Daniel L. Miranda

    9:25

    S1-6

    Effect of Graft Fixation Angels on Knee Kinematics, Graft Tension Curves and Load Sharing in Double-Bundle Anterior Cruciaet Ligament Reconstruction

    Hideyuki Koga

    9:31

    S1-7

    Intra-operative Suplementation of Vitamin C Improved Knee Laxity Restoration in Anterior Cruciate Ligament Reconstruction

    Wai Hang Cheng

    9:37

    S1-8

    Knee Kinematics After ACL Reconstruction Using Transtibial and Anteromedial Portal Surgical Techniques

    Hongsheng Wang

    9:43

     

    Discussion

     

    9:58

    S1-9

    Intra-operative Assessment of Joint Laxity in the ACL-deficient and Contralateral Healthy Knees

    Claudio Belvedere

    10:04

    S1-10

    Biomechanical Evaluation of Bioabsorbable Polymer Interference Screws for ACL Reconstruction at Time Zero and 12 Weeks of Healing in a Goat Model

    Kwang  Eun Kim 

    10:10

    S1-11

    Relationship Between Medial-to-Lateral Femoral Cartilage Thickness Ratio and Peak Knee Adduction Moment During Walking for ACL Reconstructed and Healthy Contralateral Knees

    Michael Zabala

    10:16

     

    Discussion

     

    10:26

     

    Break / Poster session

    Session Chairs:
    Louis Soslowsky, PhD,
    Stavros Thomopoulos, PhD

     

     

    Podium Session 2: Tendon and Ligament Tissue Engineering

    Session Chairs:
    Helen Lu, PhD,
    Paul Ackermann, MD, PhD

    10:56

     

    Keynote Lecture: Working across Model Systems at the Interface between Functional Tissue Engineering and Developmental Biology to Improve Adult Tendon Repair

    David Butler, PhD

    11:11

    S2-1

    Type I Collagen Synthesis in Scaffold-free, Single Fibers for Engineered Tendon

    Nathan  R. Schiele

    11:17

    S2-2

    Fabricating Scaffolds of Electrospun Nanofibres from Synthetic Biopolymers for Tendon Repair

    Lucy Bosworth

    11:23

    S2-3

    Fibrin Hydrogels Exhibit Improved Biological and Mechanical Properties Compared to Collagen Hydrogels in Tissue-engineered Constructs in vitro

    Andrew P. Breidenbach

    11:29

    S2-4

    Addition  of Collagen Fibers to MPC-Collagen Gels to Promote Tissue Engineered Construct Stiffness and Matrix Production

    Andrea Lalley

    11:35

    S2-5

    Effect of Nanofiber Alignment and Mechanical Loading on hMSC Differentiation

    Siddarth Subramony

    11:41

     

    Discussion

     

    11:56

    S2-6

    BMP-2 Eluting Biphasic Hybrid Silk Scaffold for Ligament and Bone Tunnel Regeneration

    Thomas Kok Hiong Teh

    12:02

    S2-7

    Localized, Controlled Release of Human PDGF from Highly Aligned Collagen-Nanoparticle Fiber for Tendon Repair

    Xing Guo Cheng

    12:08

    S2-8

    Low Oxygen Tension Promotes Proliferation and Enhances the Stemness of Human Tendon Stem Cells

    James H-C Wang

    12:14

    S2-9

    Alginate Encapsulated Platelet-rich Plasma and Synovial Fluid Mesenchymal Stem Cells Provided Potential to Repair the Partial Ligament Tear

    Ing-Chih Wang

    12:20

     

    Discussion

     

    12:35

     

    Lunch

     

     

     

    Podium Session 3: Rotator Cuff

    Session Chairs:
    Zong-Ming Li, PhD,
    Chih-Hwa Chen, MD, PhD

    13:35

     

    Keynote Lecture: Long head of the biceps tendon is damaged following a rotator cuff tear in a rat model:  initiation of damage and possible mechanism of injury

    Louis J. Soslowsky, PhD

    13:50

    S3-1

    Savio L-Y. Woo Young Researcher Award Winner : Chronic Rotator Cuff Tear Changes the Expression of Several Small Non-Coding RNA Molecules That Regulate Muscle Atrophy, Fibrosis and Autophagy

    Jonathan P.  Gumucio

    14:00

     

    Discussion

     

    14:05

    S3-2

    Effect of the Adipose-derived Stem Cell for the Improvement of Fatty Degeneration of the Rotator Cuff Muscle in Rabbit Model

    Seok Won Chung

    14:11

    S3-3

    Biomechanical Factors Predisposing to Propagation of Rotator Cuff Tears: Tear Size, Shoulder Elevation and Rotation, and Rotator Cuff Muscle Strength

    Teruhisa Mihata

    14:17

    S3-4

    The Arthroscopic Bone Needle. A New, Safe and Cost-effective Technique for Rotator Cuff Repair

    Jens Stehle

    14:23

     

    Discussion

     

     

     

    Podium Session 4: Tendinopathy

    Session Chairs:
    Braden Fleming, PhD,
    Nicola Maffulli, MD

    14:33

     

    Keynote Lecture: Biochemical Causes of Tendinopathy?

    Patrik Danielson, MD, PhD

    14:48

    S4-1

    Diclofenac and Trimcinolone Acetonide Impairs Medenchymal Stem Cell Growth and Their Differentiation to Tenocytes

    Maritha Fredriksson

    14:54

    S4-2

    Evidence that Aggrecan-Rich Deposits Cause Tendinopathies by Blocking Fibrogenesis

    Vincent M. Wang

    15:00

    S4-3

    Lipoxin A4 Receptor Mediated Inflamm-Aging in Flexor Tendinopathy: A Mechanism for Immunosenescence

    Stephanie Georgina Dakin

    15:06

    S4-4

    Visualization of Collagen Matrix Damage in a Tendon Fascicle Fatigue Model

    Stephen J. Ros

    15:12

    S4-5

    Effect of Degenerative Rotator Cuff Tears and Subacromial Bursa Steroid Injection on the Structural Properties of the Supraspinatus Tendon

    Jennifer Tilley

    15:18

     

    Discussion

     

    15:33

     

    Break / Poster session

    Session Chairs:
    Catherine K. Kuo, PhD,
    Wei-Hsiu Hsu, MD

     

     

    Podium Session 5: Biology and Biomechanics Tendons and Ligaments

    Session Chairs:
    PPY Lui, PhD,
    Christer Rolf, MD, PhD

    16:03

     

    Keynote Lecture: Regulation of tendon elongation by strain and Scleraxis dependent tenocytes induction

    Ronen Schweitzer, PhD

    16:18

    S5-1

    Differential Expression and Cellular Localization of Novel Isoforms of the Tendon Biomarker Tenomodulin

    Jie Qi

    16:24

    S5-2

    Effects of Stress Deprivation on Lubricin Synthesis and Gliding of Flexor Tendon

    Chunfeng Zhao

    16:30

    S5-3

    BMP12 and BMP14 Promote Tenogenesis in the Adipose-Derived Stem Cells

     Hua Shen

    16:36

    S5-4

    Cyclic and Static Stress-relaxation Properties of Bovine Tendon Fascicles – The Effect of Recovery Time

    Hazel Screen

    16:42

    S5-5

    Tendon Glycosaminoglycans - Interfibril Glue or Lube?  AFM Observations of Collagen Ultrascale Mechanics

    Jess G. Snedeker

     

     

    Discussion

     

    16:57

    S5-6

    Tracking of Mesenchymal Stem Cells in Tendon Injuries Following in vivo Administration

    Jay Dudhia

    17:03

    S5-7

    The Effect of Increasing Load on Tendon Biomechanics During Eccentric and Concentric Triceps Surae Exercises

    Saira Chaudhry

    17:09

    S5-8

    A High Calcium Diet Improves the Adaptive Response of Tendon to Exercise

    Nelly Andarawis-Puri

    17:15

    S5-9

    Mechanical and Molecular Effects of Aging on Normal Ligaments

    Gail M. Thornton

     

     

    Discussion

     

    17:30

    S5-10

    Investigating Fiber Mechanics in Functionally Distinct Tendons

    Chavaunne Thorpe

    17:36

    S5-11

    Measuring Transverse Carpal Ligament Thickness by Ultrasound

    Zhilei Liu Shen

    17:42

    S5-12

    Does Locking Configuration Affect the Biomechanical Characteristics of Extensor Tendon Repair in Zone IV?

    Kyung Chil Chung

    17:48

    S5-13

    Effects of Collagen Crosslink Inhibition on Embryonic Tendon

    Joseph E. Marturano

    17:54

    S5-14

    Rapamycin Attenuates Age-associated Changes in Tibialis Anterior Tendon
    Viscoelastic Properties

    Lauren Wood

    18:00

     

    Discussion

     

    18:15

     

    2012 ISL&T - COA

    K.M. Chan, MD

    18:20

     

    ISL&T - XIII, Perugia/Arrezzo, Italy

    Giuliano Cerulli, MD

    18:25

     

    Closing Remarks

    Chih-Hwa Chen, MD, PhD

    18:30

     

    Proceed to dinner venue

     

    19:00

     

    Reception / Dinner

    Location TBD