Integrilin (eptifibatide)
Company Dosing Handout
NOTE: in November, 2003, the company revised the dosing recommendations. They recommend halving the infusion rate for those with a calculated creatinine clearance rate of < 50. They recommend the Cockcroft-Gault Equation for calculating creatinine clearance.

Est. Creatinine Clearance = [[140 - age(yr)]*weight(kg)]/[72*serum Cr(mg/dL)]
(multiply by 0.85 for women)

An online calculator from the Medical College of Wisconsin is available for this calculation.

DOSING GUIDELINES FOR PATIENTS WITH UNSTABLE ANGINA AND NON-Q-WAVE MI, INCLUDING THOSE MANAGED MEDICALLY AND THOSE UNDERGOING PCI

Patient Weight
(kg)          (lb)		 Bolus Volume
(2mg/mL vial)		 Infusion Rate
(0.75 mg/mL vial)
37-41      81-91 3.4 mL 6 mL/h
42-46      92-102 4.0 mL 7 mL/h
47-53     103-117 4.5 mL 8 mL/h
54-59     118-130 5.0 mL 9 mL/h
60-65     131-143 5.6 mL 10 mL/h
66-71     144-157  6.2 mL 11 mL/h
72-78     158-172 6.8 mL 12 mL/h
79-84     173-185 7.3 mL 13 mL/h
85-90     186-198 7.9 mL 14 mL/h
91-96     199-212  8.5 mL 15 mL/h
97-103   213-227 9.0 mL 16 mL/h
104-109 228-240 9.5 mL 17 mL/h
110-115 241-253 10.2 mL 18 mL/h
116-121 254-267  10.7 mL 19 mL/h
>121      >267 11.3 mL 20 mL/h