[53]   "Detection of trace palladium in flasks and metal reagents using a fluorogenic Tsuji-Trost reaction" D. Li, L. D. Campbell, B. A. Austin, and K. Koide*, ChemPlusChem 2012, 1, accepted for publication. Link

[52]   "Amine-promoted β-elimination of a β-aryloxy aldehyde for fluorogenic chemodosimeters" A. K. Leslie, D. Li, and K. Koide*, J. Org. Chem. 2011, 76, 6860–6865. Link

[51]   "The use of 3,5,4'-tri-O-acetylresveratrol as a potential pro-drug for resveratrol protects mice from γ-irradiation–induced death" K. Koide,* S. Osman, A. L. Garner, F. Song, T. Dixon, J. S. Greenberger, and M. W. Epperly* ACS Med. Chem. Lett. 2011, 2, 270-274. Link
One More Reason to Guzzle Red Wine (Newsweek Magazine May 23&30, 2011 issue)

[50]   "Diastereoselective synthesis of diketopiperazine bis-α,β-epoxides" S. Ando, A. L. Grote, and K. Koide, J. Org. Chem. 2011, 76, 1155-1158. Link

[49]   "Development and applications of fluorogenic probes for mercury(II) based on vinyl ether oxymercuration" S. Ando and K. Koide, J. Am. Chem. Soc. 2011, 133, 2556-2566. Link

[48]   "Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464" S. Osman, B. J. Albert, Y. Wang, M. Li, N. L. Czaicki, K. Koide, Chem.-Eur. J. 2011, 17, 895–904. Link

[47]   "Evaluation of FR901464 analogues in vitro and in vivo" S. Osman, W. R. Waud, G. S. Gorman, B. W. Day, and K. Koide, Med. Chem. Commun. 2011, 2, 38-43. Link

[46]   "Studies toward an ideal fluorescence method to measure palladium in functionalized organic molecules: effects of sodium borohydride, temperature, phosphine ligand, and phosphate ions on kinetics" F. Song, E. J. Carder, C. C. Kohler, and K. Koide, Chem.-Eur. J. 2010, 16, 13500-13508. Link

[45]   "Meayamycin inhibits pre-mRNA splicing and exhibits picomolar activity against multidrug resistant cells" B. J. Albert, P. A. McPherson, K. O'Brien, N. L. Czaicki, V. DeStefino, S. Osman, M. Li, B. W. Day, P. J. Grabowski, M. Moore, A. Vogt, K. Koide, Mol. Cancer Ther. 2009, 8, 2308-2318. Link

[44]   "Specific fluorogenic probes for ozone in biological and atmospheric samples" A. L. Garner, C. M. St. Croix, B. R. Pitt, G. D. Leikauf, S. Ando, and K. Koide, Nature Chem. 2009, 1, 316-321. Link
New probe promises ozone answers (Chemistry World)
Pitt chemist is developing a bright idea (Pittsburgh Post-Gazette)
News in brief (Nature Methods)

[43]   "Enhancement of a catalysis-based fluorometric detection method for palladium through rational fine-tuning of the palladium species" A. L. Garner, F. Song, K. Koide, J. Am. Chem. Soc. 2009, 131, 5163–5171. Link
Green Chemistry

[42]   "External compression-induced fracture patterning on the surface of poly(dimethylsiloxane) cubes and microspheres" T. Uchida, K. L. Mills, C.-H. Kuo, W. Roh, Y.-C. Tung, A. L. Garner, K. Koide, M. D. Thouless, S. Takayama, Langmuir 2009, 25, 3102-3107. Link

[41]   "Studies of a fluorogenic probe for palladium and platinum leading to a palladium-specific detection method" A. L. Garner, K. Koide, Chem. Commun. 2009, 86-88. Link

[40]   "Fluorescent method for platinum detection in buffers and serums for cancer medicine and occupational hazards" A. L. Garner, K. Koide, Chem. Commun. 2009, 83-85. Link

[39]   "Oxidation-resistant fluorogenic probe for mercury based on alkyne oxymercuration" F. Song, S. Watanabe, P. E. Floreancig, K. Koide, J. Am. Chem. Soc. 2008, 130, 16460-16461. Link

[38]   "Oxidation state-specific fluorescent method for palladium(II) and platinum(IV) based on the catalyzed aromatic Claisen rearrangement" A. L. Garner, K. Koide, J. Am. Chem. Soc. 2008, 130, 16472-16473. Link

[37]   "Cyclic acetal formation between 2-pyridinecarboxaldehyde and γ-hydroxy-α,β-acetylenic esters" S. Osman, K. Koide, Tetrahedron Lett. 2008, 49, 6550-6552. Link

[36]   "Scalable and concise synthesis of dichlorofluorescein derivatives displaying tissue permeation in live zebrafish embryos" K. Koide, F. Song, E. D. de Groh, A. L. Garner, V. D. Mitchell, L. A. Davidson, N. A. Hukriede, ChemBioChem 2008, 9, 214-218. Link

[35]   "Zirconium-promoted epoxy rearrangement-alkynylation sequence" B. J. Albert, K. Koide, J. Org. Chem. 2008, 73, 1093-1098. Link
Best Synthetic Methods: Carbon-Carbon Bond Construction

[34]   "Solid-phase olefin cross-metathesis promoted by a linker" A. L. Garner, K. Koide, Org. Lett. 2007, 9, 5235–5238. PDF
C&E News

[33]   "Synthesis and biological activity of antitumor natural product FR901464 and its analogue" K. Koide, Farumashia 2007, 43, 1183–1188. Link

[32]   "How rapidly do epoxides non-specifically form covalent bonds with thiols in water?" B. J. Albert, K. Koide, ChemBioChem 2007, 8, 1912–1915 PDF
Cover page

[31]   "A highly sensitive fluorescent sensor for palladium based on the allylic oxidative insertion mechanism" F. Song, A. L. Garner, K. Koide, J. Am. Chem. Soc. 2007,129, 12354–12355.Link
C&E News

[30]   "Fluorescent sensors for specific RNA: A general paradigm using chemistry and combinatorial biology" B. A. Sparano, K. Koide, J. Am. Chem. Soc. 2007,129, 4785–4794. Link

[29]   "Sodium bicarbonate-catalyzed stereoselective isomerizations of electron-deficient propargylic alcohols to (Z)-enones" J. P. Sonye, K. Koide, J. Org. Chem. 2007, 72. 1846-1848. Link

[28]   "Total synthesis, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue" B. J. Albert, A. Sivaramakrishnan, T. Naka, N. L. Czaicki, K. Koide, J. Am. Chem. Soc. 2007, 129. 2648-2659.Link

[This article was highlighted on the National Public Radio, in Nature (2007, 445, p798) Link , Pitt Chronicle Link , The Pitt News Link , The Carnegie Mellon University Tartan Link , Insider R&D, BioSpace, United Press International, Medilexicon Link ]

[27]   "Review: Total syntheses of FR901464" K. Koide, B. J. Albert, J. Synth. Org. Chem. Jpn. 2007, 65. 119–126 [PDF file available upon request].

[26]   "A new paradigm for the development of fluorescent RNA imaging technology using synthetic molecules" K. Koide, American Biotechnology Laboratory 2006, 24, 8–10 [PDF file available upon request].

[25]   "Base-catalyzed stereoselective isomerization of electron-deficient propargylic alcohols to E-enones" J. P. Sonye, K. Koide, J. Org. Chem. 2006, 71. 6254–6257. Link

[24]   "Total synthesis of FR901464, an antitumor agent that regulates the transcription of oncogenes and tumor suppressor genes" B. J. Albert, A. Sivaramkrishnan, T. Naka, K. Koide, J. Am. Chem. Soc. 2006, 128. 2792–2793. Link

[23]   "Organic base-catalyzed stereoselective isomerizations of 4-hydroxy-4-phenyl-but-2-ynoic acid methyl ester to (E)- and (Z)-4-oxo-4-phenyl-but-2-enoic acid methyl esters" J. P. Sonye, K. Koide, Synth. Commun. 2006, 36, 599–602. Link

[22]   "On the mechanism of DABCO-catalyzed stereoselective isomerization of g-hydroxy-a,b-alkynoates to gamma-oxo-alpha,beta-(E)-alkenoates" J. P. Sonye, K. Koide, Org. Lett. 2006, 8, 199–202. Link

[21]   "A strategy for the development of small molecule-based sensors that strongly fluoresce when bound to a specific RNA" B. A. Sparano, K. Koide, J. Am. Chem. Soc. 2005, 127, 14954–14955. (Ranked 6th in the "Most-Accessed Articles: October–December, 2005" list) Link

[20]   "Synthesis of a C4-epi C1–C6 fragment of FR901464 using a novel bromolactolization" B. J. Albert, K. Koide, Org. Lett. 2004, 6, 3655–3658.Link

[19]   "Effect of binding and conformation on fluorescence quenching in new 2',7'-dichlorofluorescein derivatives" B. A. Sparano, S. P. Shahi, K. Koide, Org. Lett., 2004, 6, 1947–1949. Link

[18]   "Trans-selective conversions of gamma-hydroxy-alpha,beta-alkynoic esters to g-hydroxy-a,b-alkenoic esters" C. T. Meta, K. Koide, Org. Lett. 2004, 6, 1785–1787. Link

[17]   "A mild method for the preparation of gamma-hydroxy-alpha,beta-acetylenic esters" S. P. Shahi, K. Koide, Angew. Chem. Int. Ed. 2004, 43, 2525–2527. Link

[16]   "A novel and simple method to prepare g-hydroxy-a,b-(E)-alkenoic esters from g-keto-alkynoic esters" T. Naka, K. Koide, Tetrahedron Lett. 2003, 44, 443–445. Link


Graduate and Postdoctoral Work (1-15):

[15]   "A synthetic library of cell-permeable molecules", K. Koide, J. M. Finkelstein, Z. Ball, G. L. Verdine, J. Am. Chem. Soc. 2001, 123, 398. Link

[14]   "Inhibition of protein kinases by balanol: Specificity within the serine/threonine protein kinase sub-family", J. Setyawan, K. Koide, T. C. Diller, M. E. Bunnage, S. S. Taylor, K. C. Nicolaou, L. L. Brunton, Mol. Pharm. 1999, 56, 370.

[13]   "Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase", N. Narayana, T. C. Diller, K. Koide, M. E. Bunnage, K. C. Nicolaou, L. L. Brunton, N.-H. Xuong, L. F. Ten Eyck, S. S. Taylor, Biochemistry 1999, 38, 2367.

[12]   "Glycosyl 2-pyridinecarboxylate as an effective glycosyl donor: Glycosidation of mannose, 2-azidosugar, and 2-deoxysugar into disaccarides", H. Furukawa, K. Koide, K. Takao, S. Kobayashi, Chem. Pharm. Bull. 1998, 46, 1244.

[11]   "Synthetic studies on maduropeptin chromophore.  2.  Synthesis of the madurosamine aryl amide and the C1’-C9’ fragments", K. C. Nicolaou, K. Koide, J. Xu, M. H. Izraelewicz, Tetrahedron Lett. 1997, 38, 3671.

[10]   "Synthetic studies on maduropeptin chromophore. 1. Construction of the aryl ether and attempted synthesis of the [7.3.0] bicyclic system", K. C. Nicolaou, K. Koide, H. Khatuya, Tetrahedron Lett. 1997, 38, 3667.

[9]     "Glycosyl fluoride for glycosidation promoted by a catalytic amount of gallium reagent", K. Koide, M. Ohno, S. Kobayashi, Synthesis 1996, 1175.

[8]     "Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol", K. Koide, M. E. Bunnage, L. Gomez Paloma, J. R. Kanter, S. S. Taylor, L. L. Brunton, K. C. Nicolaou, Chem. Biol. 1995, 2, 601.

[7]     "Total synthesis of balanol and designed analogues", K. C. Nicolaou, K. Koide, M. E. Bunnage, Chem. Eur. J. 1995, 1, 454.

[6]     "Total synthesis of rapamycin", K. C. Nicolaou, A. D. Piscopio, P. Bertinato, N. Minowa, T. K. Chakraborty, K. Koide, Chem. Eur. J. 1995, 1, 316.

[5]     "Total synthesis of truncated brevetoxin B [AFGHIJK]", K. C. Nicolaou, J. Tiebes, E. A. Theodorakis, F. P. J. T. Rutjes, K. Koide, M. Sato, E. Untersteller, J. Am. Chem. Soc. 1994, 116, 9371.

[4]     "Total synthesis of balanol", K. C. Nicolaou, M. E. Bunnage, K. Koide, J. Am. Chem. Soc. 1994, 116, 8402.

[3]     "A highly convergent strategy towards rapamycin. Stereoselective construction of the C8-C18 fragment", A. D. Piscopio, N. Minowa, T. K. Chakraborty, K. Koide, P. Bertinato, K. C. Nicolaou, J. Chem. Soc. Chem. Commun. 1993, 7, 617.

[2]     "A new glycosylation reaction based on a remote activation concept - Glycosyl 2-pyridinecarboxylate as a novel glycosyl donor.", K. Koide,  M. Ohno,  S. Kobayashi Tetrahedron Lett. 1991, 32, 7065.

[1]     "Gallium reagents in organic synthesis: Dimethylgallium chloride and triflate as activators in glycosidation using glycopyranosyl fluorides", S. Kobayashi, K. Koide, M. Ohno, Tetrahedron Lett. 1990, 31, 2435.