Abstracts

Bein, K. and Simons, M. Thrombospondins 1 and 2 Inhibit activation of pro-metalloproteinases 2 and 9 enzymes. Supplement to Circulation, 102: #839. New Orleans, Louisiana 2000; November 12-15.

Bein, K. Characterization of His6-S peptide-MBP fusion tag produced using the baculoviral expression system. 42^nd American Society for Cell Biology Annual Meeting San Francisco 2002, Dec 14-18 Molecular Biology of the Cell Vol 13 supplement

Bein, K. TGF-B1-induced alteration of capillary tube patterning. North American Vascular Biology Organization Meeting. Pacific Grove, CA 2004. Endothelium 10: 360-61.

Leikauf, G.D., Pope-Varsalona, H. Concel, V.J., Liu, P., Bein, K., Brant, K.A., Dopico, R.A., Peter Di, Y.P., Jang, An_S., Medvedovic, M., Li, Q., Vega, L., Kaminski, N., You, M., and Prows, D.R. Candidate Susceptibility Genes Identified By Genomewide Analysis Of Chloride-induced Acute Lung Injury In Mice. Am. J. Respir. Crit. Care Med. 2010; 181: A5370

Jang, A.S., Concel, V.J. Bein, K., Brant, K.A., Liu, S., Pope-Varsalona, H. Dopico, R.A. Jr. Jr., Peter Di, Y.P., Barchowsky, A., and Leikauf G.D. Endothelial Dysfunction And Claudin 5 Regulation During Acrolein-induced Lung Injury. Am. J. Respir. Crit. Care Med..2010; 181: A3607

Bein, K and Leikauf, G.E. Macrophages Mediate LPS-Induced Increased CCAAT/enhancer Binding Protein (C/EBP), Beta (C/EBP-Beta) Transcripts In Lung Epithelial Cells Am. J. Respir. Crit. Care Med.2011; 183: A5099

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP. Integrative Assessment of Chlorine-induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2012 Mar 23. PubMed PMID: 22447970

Books and Book Chapters

Paola Grandi, Kiflai Bein, Costas G. Hadjipanayis, Darren Wolfe, Xandra O.Breakefield and Joseph C. Glorioso. Application of HSV-1 Vectors to the Treatment of Cancer. In Viral Therapy of Cancer, edited by Harrington, K.J., Vile, R.G., and Pandha, H. Chichester, England: Hoboken, NJ; John Wiley & Sons. June, 2008, Page 19.

Journal Articles

1. Bein, K., Simmer, J.P., and Evans, D.R. Molecular cloning of a cDNA encoding the amino end of the multifunctional protein CAD and analysis of the flanking region of the CAD gene. J. Biol. Chem. 1990; 266: 3791-3799. PMID: 1671675



2. Evans, D.R., Bein, K., Guy, H.I., Liu, X., Molina, A. and Zimmermann, B.H. CAD gene sequence and the domain structure of the mammalian multifunctional protein. Biochem. Soc. Trans. 1993; 21: 186-91. PMID: 8095469



3. Husain, M., Bein, K., Jiang, L., Alper, S., Simons, M. and Rosenberg, R.D. c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells. Circulation Research 1997; 80: 617-626. PMID: 9130442



4. Husain, M., Jiang, L., See, V., Bein, K., Simons, M., Alper, S., and Rosenberg, R.D. Regulation of vascular smooth muscle cell proliferation by plasma membrane Ca 2+ ATPase. American J Physiol. 1997; 272: C1947-C1959. PMID: 9227424



5. Bein, K., Husain, M., Ware, J.A., Mucenski, M.L., Rosenberg , R.D. and Simons, M. c-Myb function in fibroblasts. J. Cellular Physiol. 1997; 173: 319-326. PMID: 9369944



6. Bein, K. Ware, J.A. and Simons, M. Myb-dependent regulation of thrombospondin 2 expression: role of mRNA stability. J Biol. Chem. 1998; 273: 21423-21429. PMID: 9694906



7. Bein, K. and Simons, M. Thrombospondin type 1 repeats Interact with Matrix Metalloproteinase 2: regulation of metalloproteinase activity. J. Biol. Chem. 2000; 275: 32167-32173. PMID: 10900205



8. * Bein, K., Odell-Fiddler, E.T., Drinane, M. Role of TGF-{beta}1 and JNK signaling in capillary tube patterning. Am J Physiol Cell Physiol. 2004; 287: C1012-C1022. *Please note that the first author is the main author. PMID: 15201140



9. Odell-Fiddler, E.T. and Bein, K. Transforming growth factor B1-induced inhibition or stimulation of endothelial cell motility is mediated through an ALK5/p160Rock-dependent mechanism. 2006.



10. Odell-Fiddler, E.T. and Bein, K. 2007. The dual effects of TGF-B1 on endothelial cell motility are dictated by pericellular context. Molecular and Cellular Biology (Submitted).



11. Li H, Baskaran R, Krisky DM, Bein K, Grandi P, Cohen JB, Glorioso JC. Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. Virology. 2008 Mar 3. PMID: 18321553



12. Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD.  Surfactant Associated Protein B is Critical to Survival in Nickel-induced Injury in Mice.  Am J Respir Cell Mol Biol. 2009 Jan 8. PMID: 19131640



13. Koustav Ganguly, Martin Depner, Cheryl Fattman, Kiflai Bein, Tim D. Oury, Scott C. Wesselkamper, Michael Thomas Borchers, Martina Schreiber, Fei Gao, Erika von Mutius, Michael Kabesch, George D. Leikauf, and Holger Schulz.  Superoxide dismutase 3, extracellular (SOD3) variants and lung function.  Physiol. Genomics. 2009 May 13;37(3):260-7. Epub 2009 Mar 24. PMID: 19318538



14. Stark JM, Barmada MM, Winterberg AV, Majumber N, Gibbons WJ Jr, Stark MA, Sartor MA, Medvedovic M, Kolls J, Bein K, Mailaparambil B, Krueger M, Heinzmann A, Leikauf GD, Prows DR. Genomewide association analysis of respiratory syncytial virus infection in mice. J Virol. 2009 Dec 16. PubMed  PMID: 20015999



15. An_Soo Jang, Vincent J. Concel, Kiflai Bein, Kelly A. Brant, Shannen Liu, Hannah Pope-Varsalona, Richard A. Dopico, Jr., Jr., Y.P. Peter Di, Aaron Barchowsky, and George D. Leikauf. Endothelial Dysfunction And Claudin 5 Regulation During Acrolein-induced Lung Injury. Am J Respir Cell Mol Biol. 2011 Apr;44(4):483-90. Epub 2010 Jun 4. PubMed PMID: 20525806



16. Leikauf G.D., Pope-Varsalona H., Concel V.J., Liu P., Bein K., Brant K.A., Dopico R.A.Jr, Di Y.P., Jang A-S., Dietsch M., Medvedovic M., Li Q., Vuga L.J., Kaminski N., You M., Prows D.R. Functional genomics of chlorine-induced acute lung injury in mice. Proc. Am. Thorac. Soc. 2010 Jul;7(4):294-6. PubMed PMID: 20601635



17. Bein K, Leight H, Leikauf GD. JUN-CCAAT/Enhancer Binding Protein (C/EBP) Complexes Inhibit Surfactant Associated Protein B Promoter Activity. Am J Respir Cell Mol Biol. 2010 Dec 10. PubMed PMID: 21148742



18. Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA, Dietsch M, Pope-Varsalona H, Dopico Jr RA, Di YP, Li Q, Vuga LJ, Medvedovic M, Kaminski N, You M, Prows DR. Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1. Am J Respir Crit Care Med. 2011 Feb 4. PubMed PMID: 21297076



19. Fabisiak JP, Medvedovic M, Alexander DC, McDunn JE, Concel VJ, Bein K, Jang AS, Berndt A, Vuga LJ, Brant KA, Pope-Varsalona H, Dopico RA Jr, Ganguly K, Upadhyay S, Li Q, Hu Z, Kaminski N, Leikauf GD. Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury. Mol Nutr Food Res. 2011 Aug 8. doi: 10.1002/mnfr.201100291. PubMed PMID: 21823223

Review Articles

Bein, K. and Leikauf, G.D. (2011). Acrolein – a pulmonary hazard. Molecular Nutrition & Food Research (September 2011), 55 (9), pg. 1342-1360. Article first published online: 17 AUG 2011. DOI: 10.1002/mnfr.201100279

Joint Presentations

Leikauf, G.D., Concel, V., Liu, P., Dietsch, M., Bein, K., Majumder, N., Jang, A-S., Borchers, M.T., Tichelaar, J.A., Prows, D.R., Hardie, W., Korfhagen, T., and You, M. Functional Genomics of Chemical Induced Acute LUng Injury. Countermeasures Against Chemical Threats. Washington, D.C., 2008.

Presentations