Department of Environmental and Occupational Health

Activities Awards Grants Publications Presentations Research Teaching

Pearce/Peterson - Publications

Last 5 years (* indicates submitting author)

    1. N.A. Belikova, Y.A. Vladimirov, A.N. Osipov, A.A. Kapralov, V.A. Tyurin, M.V. Potapovich, L.V. Basova, J. Peterson, I.V. Kurnikov, V.E. Kagan*:  “Peroxidase Activity and Structural Transitions of Cytochrome c Bound to Cardiolipin-containing Membranes”; Biochemistry 45, 4998-5009 (2006). PMID: 16605268

    2. L.V. Basova, I.V. Kurnikov, L. Wang, V.B. Ritov, N.A. Belikova, I.I. Vlasova, A.A. Pacheco, D.E. Winnica, J. Peterson, H. Bayir, D.H. Waldeck, V.E. Kagan*:  “Cardiolipin Switch in Mitochondria:  Shutting off the Reduction of Cytochrome c and Turning on the Peroxidase Activity”; Biochemistry 46, 3423-3434 (2007). PMID: 17319652

    3. L.L. Pearce*, S. Martinez-Bosch, E. Lopez Manzano, J. Peterson*:  “The Antagonism of Nitric Oxide Toward the Inhibition of Cytochrome c Oxidase by Carbon Monoxide and Cyanide”; Chem. Res. Tox. 21, 2073-2081 (2008).  PMID: 18956847

    4. L.L. Pearce*, S. Martinez-Bosch, E. Lopez Manzano, D.E. Winnica, M.W. Epperly, J. Peterson*:  “The Resistance of Electron Transport Chain Fe-S Clusters to Oxidative Damage during the Reaction of Peroxynitrite with Mitochondrial Complex II and Rat Heart Pericardium”; Nitric Oxide 20, 135-142 (2009). PMID: 19118636

    5. M.W. Epperly, J.A. Melendez, X. Zhang, S. Nie, L.L. Pearce, J. Peterson, D. Franicola, T. Dixon, B.A. Greenberger, P. Komanduri, H. Wong and J.S. Greenberger*: “Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases Radioresistance In Vitro and In Vivo”; Rad. Res. 171, 588-595 (2009).

    6. M. Otsuka, S.A. Marks, D.E. Winnica, A.A. Amoscato, L.L. Pearce and J. Peterson*: Covalent Modifications of Hemoglobin by Nitrite Anion: Formation Kinetics and Properties of Nitrihemoglobin. Chem Res Toxicol. 2010 Oct 20. PubMed PMID: 20961082

    7. Stitt-Fischer MS, Ungerman RK, Wilen DS, Wasserloos K, Renz LM, Raub SE, Peterson J, Pearce LL. Manganese Superoxide Dismutase is not Protective in Bovine Pulmonary Artery Endothelial Cells at Systemic Oxygen Levels. Radiat Res. 2010 Dec;174(6):679-90. Epub 2010 Sep 28. PubMed PMID: 21128791

    8. Kapralov AA, Yanamala N, Tyurina YY, Castro L, Arias AS, Vladimirov YA, Maeda A, Weitz AA, Peterson J, Mylnikov D, Demicheli V, Tortora V, Klein-Seetharaman J, Radi R, Kagan VE. Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes. Biochim Biophys Acta. 2011 Sep;1808(9):2147-55. Epub 2011 Apr 29. PubMed PMID: 21550335

    9. Cambal LK, Swanson MR, Yuan Q, Weitz AC, Li HH, Pitt B, Peterson J, Pearce LL. Acute, Sub-lethal Cyanide Poisoning in Mice is Ameliorated by Nitrite Alone: Complications Arising from Concomitant Administration of Nitrite and Thiosulfate as an Antidotal Combination. Chem Res Toxicol. 2011 Jul 18;24(7):1104-12. Epub 2011 May 11. PMID:21534623

    10. Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun. 2011 Oct 11;2:497. doi: 10.1038/ncomms1499. PubMed PMID: 21988913

    11. Pearce LL, Zhang X, Martinez-Bosch S, Kerr PP, Khlangwiset P, Epperly MW, Fink MP, Greenberger JS, Peterson J. l-Arginine is a Radioprotector for Hematopoietic Progenitor Cells. Radiat Res. 2011 Dec 16. PubMed PMID: 22175298

    12. O. S. Benz, Q. Yuan, A. A. Amoscato, L.L. Pearce* and Jim Peterson*: “The Metalloporphyrin CoIIITMPyP Ameliorates Acute, Sub-lethal Cyanide Toxicity in Mice” Chem. Res. Toxicol. 25, 2687–2703, (2012).

    13. Sang-Min Lee1, 2, Joseph N. McLaughlin1, Daniel R. Frederick1, Lin Zhu1, Karla Wasserloos2, Iris Kaminski2, Octavia Peck-Palmer, Linda Pearce2,  Jim Peterson2, CBI Person, Jin; Joseph D. Latoche, Tim D. Oury, Cheryl L. Fattman2, Donna Beer-Stolz3, John F. Alcorn4, Derek C. Angus1, Bruce R. Pitt2, A. Murat Kaynar1   “Metallothionien-induced zinc partitioning exacerbates hyperoxic induced lung injury”, Am J Physiol Lung Cell Mol Physiol March 1, (2013) 304:L350-L360.

    14. Leah K. Cambal Andrew C. Weitz, Hui-Hua Li, Xi Zheng, Linda L. Pearce and Jim Peterson “Alternative Nitrite Therapies for Acute Cyanide Poisoning in Mice: Complications Arising from Anesthetics” Chem. Res. Toxicol. 26, 828-836 (2013)

    15. Angela Fagoǂ§, Alvin L. Crumbliss¶, Michael P. Hendrichǁ, Linda L. Pearce**, Jim Peterson**, Robert Henkens§, and Celia Bonaventura§ “Oxygen Binding to Partially Nitrosylated Hemoglobin” Biochimica Biophysica Acta - Proteins and Proteomics In Press, Accepted Manuscript, Available online April 25 (2013)

    Published Abstracts (last 5 years)

    OXIDANT-LINKED MITOCHONDRIAL MECHANISMS OF CELL DEATH IN IRRADIATED TISSUE.  J. Peterson, S. Martinez-Bosch, D.E. Winnica, L.L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Radiation Research Society, 53rd Annual Meeting, Philadelphia, 2006.

    EFFECTS OF L-ARGININE ON MITOCHONDRIAL RESPIRATORY FUNCTION IN IRRADIATED HEMATOPOIETIC PROGENITOR CELLS.  S. Martinez-Bosch, M.W. Epperly, P. Khlangwiset, J. Peterson, L.L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Society for Free Radicals in Biology and Medicine, 13th Annual Meeting, Denver, 2006.

    NITRIC OXIDE AND THE STANDARD THERAPY FOR ACUTE CYANIDE POISONING.  J. Peterson, E. Lopez Manzano, S. Martinez-Bosch, L. L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Second International Meeting on the Role of Nitrite in Physiology, Pathophysiology, and Therapeutics, Bethesda MD, 2007.

    OXIDATION OF HYDROETHIDINE FLUORESCENT PROBES BY COMPONENTS OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN. E.A. Ungerman, O. Benz, P.P. Kerr, S. Martinez-Bosch, J. Peterson, L. L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Society for Free Radicals in Biology and Medicine, 14th Annual Meeting, Washington DC, 2007.

    RESISTANCE OF ELECTRON TRANSPORT CHAIN IRON-SULFUR CENTERS TO OXIDATIVE DEGRADATION BY PEROXYNITRITE. J. Peterson, S. Martinez-Bosch, D.E. Winnica, M.W. Epperly, L. L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Society for Free Radicals in Biology and Medicine, 14th Annual Meeting, Washington DC, 2007.

    DIRECT IRRADIATION AND RADIATION-INDUCED BYSTANDER RESPONSES BOTH RESULT IN MITOCHONDRIAL DYSFUNCTION IN HEMATOPOIETIC PROGENITOR CELLS. P. Khlangwiset, S. Martinez-Bosch, M.W. Epperly, J. Peterson, L. L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Society for Free Radicals in Biology and Medicine, 14th Annual Meeting, Washington DC, 2007.

    FUNCTIONAL STUDIES OF NITRIHEMOGLOBIN. M. Otsuka, D.E. Winnica, L. L. Pearce, J. Peterson; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Society for Free Radicals in Biology and Medicine, 14th Annual Meeting, Washington DC, 2007.

    NITRIC OXIDE, NITRITE AND THE STANDARD THERAPY FOR ACUTE CYANIDE INTOXICATION.  J. Peterson, L.K. Cambal, M.R. Swanson, E. Lopez Manzano, L.L. Pearce & B.R. Pitt; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Third Annual CounterACT Meeting, Washington DC, 2009.

    NITRIC OXIDE, NITRITE AND THE STANDARD THERAPY FOR ACUTE CYANIDE INTOXICATION.  J. Peterson, L.K. Cambal, M.R. Swanson, E. Lopez Manzano, B.R. Pitt & L.L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Third International Meeting on the Physiology, Pathophysiology and Therapeutics of Nitrite, Stockholm, Sweden, 2009.

    THE PUZZLING OXYGEN DEPENDENCE OF THE OXIDATION OF CYTOCHROME C BY PEROXYNITRITE. Elisenda Lopez Manzano, Jim Peterson, & Linda L. Pearce Society for Free Radicals in Biology and Medicine, 16th Annual Meeting, San Francisco, 2009.

    MANGANESE SUPEROXIDE DISMUTASE IS NOT RADIOPROTECTIVE IN BOVINE PULMONARY ARTERY ENDOTHELIAL CELLS AT SYSTEMIC OXYGEN. Molly Stitt-Fischer, Rachel K. Ungerman, Daniel S. Wilen, Lara M. Huyler, Shannon E. Raub, Jim Peterson and Linda L. Pearce Society for Free Radicals in Biology and Medicine, 16th Annual Meeting, San Francisco, 2009.

    Jim Peterson, Leah K. Cambal, Megan R. Swanson, Elisenda Lopez Manzano, Bruce R. Pitt & Linda L. Pearce. Third International Meeting on the Physiology, Pathophysiology and Therapeutics of Nitrite “Nitric Oxide, Nitrite and the Standard Therapy for Acute Cyanide Intoxication.

    OLD MYTHS AND NEW UNCERTAINTIES REGARDING THE ACTION OF SODIUM NITRITE IN THE AMELIORATION OF CYANIDE INTOXICATION. J. Peterson; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health. 17th Biennial, Hunt Valley MD, 2010.

    ACUTE CYANIDE TOXICITY, COMPLEX IV, NO AND NITRITE. J. Peterson, L.L. Pearce & B.R. Pitt; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health. Fourth Annual CounterACT Meeting, San Francisco CA, 2010.

    MANGANESE SUPEROXIDE DISMUTASE IS NOT RADIOPROTECTIVE IN BOVINE PULMONARY ARTERY ENDOTHELIAL CELLS AT SYSTEMIC OXYGEN LEVELS.  L.L. Pearce and J. Peterson; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Radiation Research Society 56th Annual Meeting, Maui HI 2010.

    ACUTE CYANIDE TOXICITY, METHEMOGLOBIN, NITRITE AND THIOSULFATE.  J. Peterson, L.K. Cambal, Q. Yuan,A.C. Weitz, Xi Zheng, H.-H. Li, Bruce R. Pitt & L.L. Pearce; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health.  Fifth Annual CounterACT Meeting, Washington DC, 2011.

    Books and Book Chapters

    Samantha Malone, Linda L. Pearce and Jim Peterson “Environmental Toxicology of Cyanide” in Clinical and Experimental Toxicology of Cyanides, 2nd edition edited by G. Isom & B. Bard, submitted in final form in August 2012 for publication in 2013.

    Publication Review (last 5 years)

    Dates Journal Title
    October 2005 Journal of the American Chemical Society (F. Ann Walker, Ed.)
    December 2005 Journal of Chemical Education (John W. Moore, Ed.)
    February 2007 Nitric Oxide:  Biology & Chemistry (Jack Lancaster, Ed.)
    April 2007 Antioxidants & Redox Signaling (Chandan Sen, Ed.)
    May 2007 Biochimica et Biophysica Acta (Denise M. Wells, Ed.)
    July 2007 Toxicological Sciences (Aaron Barchowsky, Assoc. Ed.)
    July 2007 Biophysical Journal (Eduardo Perozo, Ed.)
    August 2009 Chemical Research in Toxicology (Judy Bolton, Assoc. Ed.)
    September 2009 Antioxidants & Reodx Signaling (Valerian Kagan, Exec. Ed.)
    November 2009 Journal of the American Chemical Society (F. Ann Walker, Ed.)
    January 2010 Journal of Chemical Education (Alice Teeter, Assist. Ed.)
    July 2010 Toxicological Sciences (Aaron Barchowsky, Assoc. Ed.)
    June 2011

    Biochemistry (Gary Brudvig, Assoc. Ed.)
    September 2011

    PLoS ONE (Marianne Koritzinsky, Acad. Ed.)
    October 2011

    PLoS ONE (Marianne Koritzinsky, Acad. Ed.)