International Symposium on Ligaments and Tendons III

New Orleans, LA
February 1, 2003


We would like to welcome you to the third International Symposium on Ligaments and Tendons (ISL&T-III). In the past, we have been able to successfully bring together biologists, clinicians and bioengineers under one roof to present and discuss new developments in ligament and tendon research.

ISL&T-III is again a high-quality, focused meeting devoted to ligament and tendon biomechanics, biology, tissue engineering and treatments of injury. ISL&T-III will include sessions on biology and function of ligaments and tendons, biomechanics of upper and lower extremities, tissue engineering, pathophysiology and other hot topics. This year's highlight will consist of a special symposium on tendinopathy.

We thank our local hosts, Dr. Deryk Jones and his staff in Tulane University for all their assistance in the planning of this meeting. In New Orleans, we are looking forward to free exchange of current scientific information, lively discussion as well as the renewal of friendships and making new ones.

Sincerely,

Savio L-Y. Woo, Ph.D., D.Sc.
Zong-Ming Li, Ph.D.
Fengyan Jia, M.D.
ISL&T-III Planning Committee



The International Symposium on Ligaments & Tendons provides a forum to discuss state-of-the-art ligament and tendon research. By bringing together some of the best minds in the field, we hope to address challenging problems in ligament and tendon biomechanics and biology, and set new research directions that hold great potential for the future.

ISL&T-III will be at Tulane University School of Medicine Auditorium, located at 1430 Tulane Avenue, New Orleans, LA 70112.

Click here for an image of the campus map.

Savio L-Y. Woo, Ph.D., D.Sc. - Chair
Diann DeCenzo, M.S. - Treasurer
Serena Chan Saw, M.S.
Fengyan Jia, M.D.
Zong-Ming Li, Ph.D.
Colleen O'Hara, B.S.

Deryk G. Jones, M.D. - Chair
Stephen Cook, Ph.D.
Gerrie Savage
Sherry Werner, Ph.D.

Steven Arnoczky, DVM (North America)
Albert Banes, Ph.D. (North America)
Bruce Beynnon, Ph.D. (North America)
Giuliano Cerulli, M.D. (Europe)
Chih Hwa Chen, M.D. (Asia)
Tassos Georgoulis, M.D. (Europe)
Fengyan Jia, M.D. (North America)
Masahiro Kurosaka, M.D. (Asia)
Zong-Ming Li, Ph.D. (North America)
Per Renström, M.D., Ph.D. (Europe)
Scott Rodeo, M.D. (North America)
William Walsh, Ph.D. (Australia)
Jennifer Wayne, Ph.D. (North America)
Jeff Weiss, Ph.D. (North America)

Thank you for participating as a moderator in ISL&T - III. Please arrive in the presentation room at least 15 minutes before the session is scheduled to begin, in order to gather all the presenters and to work with the projectionist. For each presentation, please introduce the speaker, their affiliation, and the title of the presentation.

Moderators are responsible for keeping the sessions on schedule. Please ensure that each presentation starts and ends on time, and that there is sufficient time for questions and discussion within the allotted time.

The goal of the International Symposium on Ligaments and Tendons is to discuss state-of-the-art knowledge and to present new directions for research. Therefore, the time for presentations has been limited, in favor of discussion. Please see the presentation formats listed below. We have asked your moderators to adhere to the time allotted for your presentation as well as the number of slides.

• For Session 1, Session 2 & Session 3
• 10 min presentations each immediately followed by a 5 min discussion.
• Maximum 10 PowerPoint slides for computer presentation.
• For Session 4A & Session 4B
• 5 min presentations followed by a group discussion of 2-3 papers.
• Maximum 5 PowerPoint slides for computer presentation.

Kindly note that all speakers must be prepared to present their research using PowerPoint computer projection. We ask that you send your PowerPoint presentation file to us by January 20, 2003 so that we can load all talks into a master computer prior to the symposium. Please make sure you clearly label your file with the author's name and the title of your presentation.

In view of time and the large number of talks, there will be no opportunity for you to use your personal computer or load your PowerPoint file during the symposium.

All speakers are asked to check-in with the session moderators at least 15 minutes before the session in which they will present to meet the projectionist and the moderator.

All posters should be no larger than 45" x 45". Poster boards will be available in the lobby prior to registration. Please set up your poster between 7:30 am - 8:00 am and leave the posters up throughout the day. Posters are to be taken down by 5:30 pm.

8:00 - 8:20 am	Registration and Check-In
8:20 - 8:30 am	Opening Ceremony, Welcome & Announcements Savio L-Y. Woo, Ph.D., D.Sc. (Hon.)

Session 1: Biology and Function of Ligaments and Tendons
Session Moderators: Kai-Nan An, Ph.D. & Bruce Beynnon, Ph.D.

8:30 am	A Mechanism for the Development of a SLAP Lesion in Throwers p. 8 JE Tibone, MG Grossman, MH McGarry, DJ Schneider, TQ Lee
8:45 am	Mechanical Properties of Endobutton Constructs Used in ACL Reconstruction p. 9 PC Stephens, T Miwa, A Perry, D Acton, R Evans, W Bruce, WR Walsh
9:00 am	Migration of Markers Attached to Anterior Cruciate Ligament Soft Tissue Grafts After Cyclic Loading: A Study Using Roentgen Stereophotogrammetric Analysis (RSA) p. 10 PJ Roos, ML Hull, SM Howell
9:15 am	Inter-Insertion Distances Measured Over Time in Both Damaged and Intact Knee Ligaments After ACL/MCL Injury p. 11 JE Tapper, Y Funakoshi, M Hariu, C Sutherland, GM Thornton, JL Ronsky NG Shrive, CB Frank
9:30 am	Impact of Suture Technique and Tendon Preparation on the Interference Fixation Strength of Quadrupled Hamstring Tendon Grafts p. 12 S Scheffler, ES Steenlage, DNM Caborn, A Weiler, J Hoher
9:45 am	Evidence of Functional Graft Elongation During Running One Year After ACL Reconstruction p. 13 S Tashman, W Anderst, D Collon
10:00 - 10:25 am	Break and Poster Session

Session 2: Special Symposium - Tendinopathy
Session Moderators: Lou Soslowsky, Ph.D. & Ranjan Gupta, M.D.

10:25 am	Introduction by Moderators
10:30 am	Tendinopathy: Biology & Etiology p. 14 SP Arnoczky
10:42 am	The Molecular Biology of Tendons: Regulating Signaling and Gene Expression in with Ligands and Mechanical Load p. 15 AJ Banes, M Tsuzaki, M Wall, J Qi
10:54 am	A Mechanobiological Approach to Study Cellular and Molecular Mechanisms for the Development of Tendinopathy p. 16 JH-C Wang, ZZ Li, G Yang, D Stone, SL-Y Woo
11:06 am	Aspects of Functional Tissue Engineering in Tendinopathies p. 17 DL Butler, H Awad, MT Harris, MR Dressler, N Juncosa, J West, GP Boivin, R Young, M Galloway
11:18 am	Clinical Management of Tendinopathy p. 18 PA Renström
11:30 am	The Scientific Basis for Progressive Rehabilitation of Rotator Cuff Tendinopathy p. 19 WB Kibler, B Wise, TL Uhl
11:42 am	Discussion
12:00 - 1:00 pm	Lunch

Session 3: Biomechanics of the Upper & Lower Extremities
Session Moderators: Jennifer Wayne, Ph.D. & Anastasios Georgoulis, M.D.

1:00 pm	Pilot Study of the In Vivo Kinematic Analysis of the Pivot Shift Phenomenon Using Electromagnetic Device p. 20 S Kubo, S Yoshiya, H Muratsu, M Yagi, K Mizuno, M Kurosaka
1:15 pm	Determination of Optimal Graft Lengths in Cruciate Ligament Reconstruction p. 21 G Li, LE DeFrate
1:30 pm	The Mechanical Consequences of Gender Differences in Single Limb Alignment During Landing p. 22 AM Chaudhari, BK Hearn, LA Leveille, TP Andriacchi
1:45 pm	Knee Internal-External Rotation After ACL Reconstruction p. 23 C Papageorgiou, S Ristanis, G Giakas, N Stergiou, A Georgoulis
2:00 pm	Knee Mechanics of Posterior Cruciate Ligament Deficient Patients During Stair Descending p. 24 S Iwata, T Nagura, Y Suda, H Matsumoto, Y Toyama, TP Andriacchi
2:15 pm	Ligamentous Restraint to Anterior Translation and External Rotation in the Apprehension Position: Biomechanical Assessment of Simulated Anterior Shoulder Instability p. 25 T Mihata, YS Lee, MH McGarry, M Abe, TQ Lee
2:30 - 3:00 pm	Break (Poster Session)

Session 4A: Tissue Engineering
Session Moderators: Evan Flatow, M.D. & Jeffrey Weiss, Ph.D.

3:00 pm	Mouse Tendon Mechanical Properties Vary Significantly With Genetic Background and Exercise p. 26 VM Wang, CW Tsai, H Wolde-Semait, EL Flatow, KJ Jepsen
3:05 pm	Comparison of Skin, Patellar Tendon and Medial Collateral Ligament Scars in the Same Rabbit - Biomechanical and Histological Study p. 27 A Omine, GM Thornton, LL Marchuk, NG Shrive, Y Funakoshi, CB Frank
3:10 pm	Discussion
3:20 pm	Identification of Genes Over-Expressed in Fibroblasts Derived From the Stress-Shielded Patellar Tendon-PCR-Based Subtractive Hybridization Analysis p. 28 N Kitamura, H Tohyama, M Hatano, M Suzuki, J Nishihira, K Yasuda
3:25 pm	The Effect of Amplitude and Frequency of Cyclic Tensile Stress on the Inhibition of MMP-1 Expression in Rat Tail Tendon Cells p. 29 M Lavagnino, T Tian, ZM Vaupel, SP Arnoczky
3:30 pm	Gene Expression and Cytoskeletal Tensional Homeostasis: Evidence for a Mechanostat Set Point in Tendon Cells p. 30 SP Arnoczky, T Tian, K Gardner, M Lavagnino
3:35 pm	Dicussion
3:45 pm	Norepinephrine-Induced Calcium Signaling Via Alpha-Adrenoceptors in Avian Tendon Surface Cells and Internal Fibroblasts p. 31 ME Wall, X Yang, JE Faber, AJ Banes
3:50 pm	Human Tendon Cells Release ATP in Response to Load or UTP p. 32 M Tsuzaki, D Bynum, L Almekinders, J Faber, R Graff, AJ Banes
3:55 pm	Discussion

Session 4B: Pathophysiology
Session Moderators: Kazunori Yasuda, M.D., Ph.D. & Martha Murray, M.D.

4:05 pm	Cyclic Loading Alters Biomechanical Properties and Secretion of PGE2 and NO from Tendon Explants p. 33 J Flick, A Devkota, M Tsuzaka, A Banes, L Almekinders, P Weinhold
4:10 pm	The Role of the Cruciate Ligaments in Deep Knee Flexion p. 34 DI Caruntu, C Spanu, MS Hefzy
4:15 pm	Variations in Tendon-to-Bone Healing in an Animal Model of Graft-Tunnel Motion: An Experimental Study in Rabbits p. 35 S Rodeo, HJ Kim, C Dynybil, S Kawamura, L Ying
4:20 pm	Discussion
4:30 pm	The Calcium Phosphate Hybridization Method Results in the Regeneration of a Direct Insertion at the Tendon-Bone Tunnel Interface p. 36 M Sakane, T Sato, H Mutsuzaki, I Yamaguchi, J Zeminski, Y Miyanaga, H Nakajima, J Tanaka, N Ochiai
4:35 pm	Immunohistochemical Studies on Post-Traumatic Joint Contractures: Osteocalcin Expression in Human Elbow Joint Capsules p. 37 KA Hildebrand, W van Snellenberg
4:40 pm	MMP2 Activity in ACL Versus MCL Under Injurious Stretching Conditions p. 38 PN Siparsky, AH Teng, KLP Sung
4:45 pm	Discussion
5:00 pm	Discussion of Future Direction for ISL&T Savio L-Y. Woo, Ph.D., D.Sc. (Hon.)
5:30 - 6:15 pm	Transportation to Kung's Dynasty Restaurant, 1912 St. Charles Ave., 504-525-6669
6:15 - 7:00 pm	Cocktails
7:00 - 9:00 pm	Dinner

8:00 am - 5:00 pm

CDMPs in Tendon Repair p. 39 P Aspenberg, C Forslund Effect of Suture Type on the Performance Over a Suture Anchor Eyelet p. 40 D Acton, A Perry, R Evans, P Stephens, A Butler, W Bruce, J Goldberg, D Sonnabend, WR Walsh Human Tendon Cells Express Multiple Titin Isoforms with Long Spring Elements p. 41 AJ Banes, J Qi, X Yang, L Almekinders, D Bynum IL-1B Induced MMP's Degrade Collagen in Rabbit Achilles Tendons p. 42 KF Bowman, M Tsuzaki, K Spencer, J Archambault, G Guyton, AJ Banes Periodicity of ACL Deficient Patients During Walking: An Application of the Chaos Theory p.43 AD Georgoulis, T Moraiti, G Giakas, N Stergiou, CD Papageorgiou Cyclic Stretching of Human Patellar Tendon Fibroblasts Induces Production of PGE2 and LTB4 in a Balanced Mannerp. 44 ZZ Li, G Yang, M Khan, D Stone, SL-Y Woo, JH-C Wang A Biomechanical Analysis of Braided Soft Tissue Grafts p. 45 N Patel, W Silver, P Weinhold, S Karas Why is There Pain with Carpal Tunnel Syndrome p. 46 K Rowshan, T Chao, P Bui, LS Rummler, T Mozaffar, R Gupta