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Roles and Affiliations:
Director: Program in Cognitive Affective Neuroscience (PICAN) Director of Affective Neuroscience: Biometrics Research Program and Clinical Cognitive Neuroscience Lab. Associate Professor: University of Pittsburgh, Department of Psychology,, Cognitive Program and Clinical Program. Associate Professor: Center for the Neural Basis of Cognition. Research Associate: VA Pittsburgh Healthcare System |
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I direct the Program in Cognitive Affective Neuroscience, which has a number of ongoing projects.
I am also on the executive team of the Mood Disorders Treatment and Research Program (MDTRP) which is the clinical trials unit for Western Psychiatric Institute and Clinic. We do our psychotherapy and psychopharmacology studies through the MDTRP.
My lab has opportunities for post-docs as well as undergraduates, and research assistants.
It's important to me to devote adequate time to mentoring each
student in my lab. Due to the large number of graduate students currently
affiliated with my lab, this year (Fall 2008) I don't currently intend to consider taking an incoming graduate student for entry in Fall 2009.
Web-based projects include:
The
Balanced Affective Word List Project and the
Connectionist Models of Cognitive, Affective, Brain, and Behavioral Disorders website
Webmaster for: Program in Cognitive Affective Neuroscience, Biometrics Research Program, Cognitive Therapy and Research, Cognitive Clinical Assessment Lab
I received my Ph.D. through the San Diego State University / University of California, San Diego Joint Doctoral Program in Clinical Psychology.
Siegle, G.J., Condray, R., Thase, M.E., Keshavan, M., Steinhauer, S.R. (in press). Sustained gamma-band EEG during emotional information processing in depression and schizophrenia. International Journal of Psychophysiology
Jones, N., Siegle, G.J., Thase, M.E. (in press). Effects of rumination and initial severity on response to Cognitive Therapy for depression. Cognitive Therapy and Research
Silk, J. S., Siegle, G. J., Whalen, D. J., Ostapenko, L., Ladouceur, C. D., & Dahl, R. E. (in press). Pubertal changes in emotional information processing: pupillary, behavioral, and subjective evidence during emotional word identification. Development and Psychopathology.
4.DeRubeis, R.J., Siegle, G. J., Hollon, S., (2008). Cognitive therapy versus medications for depression: treatment outcomes and neural mechanisms. Nature neuroscience: Reviews, 9, 788-796.
Siegle, G.J., Ichikawa, N., Steinhauer, S.R. (2008). Blink before and after you think: Blinks occur prior to and following cognitive load indexed by pupillary responses. Psychophysiology, 45, 679-687.
Franzen, P.L., Siegle, G.J., Buysse, D.J. (2008). Relationships between Affect, Vigilance, and Sleepiness Following Sleep Deprivation. Journal of Sleep Research, 17, 34-41.
Silk, J.S., Dahl, R.E., Ryan, N.D., Birmaher, B., Axelson, D. Siegle, G.J. (2007). Pupillary reactivity to emotional information in child and adolescent depression: Links to clinical and ecological measures. American Journal of Psychiatry, 164, 1873-1880.
Siegle, G.J., Ghinassi, F., Thase, M.E. (2007). Neurobehavioral therapies in the 21st century: Summary of an emerging field and an extended example of Cognitive Control Training for depression. Cognitive Therapy and Research, 31, 235-262.
Siegle, G.J., Thompson, W., Thase, M.E., Steinhauer, S.R., Carter, C. S., (2007). Increased amygdala and decreased dorso-lateral prefrontal BOLD responses in unipolar depression: Related and independent features. Biological Psychiatry, 61, 198-209.
Forbes, E.E., May, J.C., Siegle, G.J., Ladouceur, C.D., Ryan, N.D., Carter, C.S., Dahl, R.E. (2006). Reward-Related Decision-Making in Pediatric Anxiety and Major Depressive Disorders: An fMRI Study. Journal of Clinical Child and Adolescent Psychology, 47, 1031-1040.
Siegle, G.J. (2006). From brain imaging to intervention: Disruptions of emotional reactivity in unipolar depression. Japanese Journal of Research on Emotions, 13, 65-82.
Larson, C., Schaefer, H.S., Siegle, G.J., Jackson, C. A. B., Anderle, M.J., Davidson, R.J. (2006). Fear is fast in phobic individuals: Amygdala activation in response to fear-relevant stimuli. Biological Psychiatry. 60, 410-417.
Siegle, G.J., Carter, C.S., Thase, M.E. (2006). Use of fMRI to predict recovery from unipolar depression with Cognitive Behavior Therapy. American Journal of Psychiatry, 163, 735-738. published pdf (subscriber access only). preprint pdf.
Siegle, G.J., Steinhauer, S.R., Thase, M.E. (2004). Pupillary Assessment and Computational Modeling of the Stroop Task in Depression. International Journal of Psychophysiology. 52, 63-76. preprint pdf
Siegle, G. J., Steinhauer, S.R., Stenger, V.A., Konecky, R., Carter, C. S., (2003). Use of concurrent pupil dilation assessment to inform interpretation and analysis of fMRI data. Neuroimage. 20(1), 114-124. preprint pdf
Siegle, G. J., Steinhauer, S.R., Carter, C. S., Ramel, W., Thase, M.E. (2003). Do the seconds turn into hours? Relationships between sustained pupil dilation in response to emotional information and self-reported rumination. Cognitive Therapy and Research. 27, 365-383. preprint pdf
Siegle, G. J., Steinhauer, S.R., Thase, M.E., Stenger, V.A., Carter, C. S., (2002). Can't Shake that Feeling: fMRI Assessment of Sustained Amygdala Activity in Response to Emotional Information in Depressed Individuals. Biological Psychiatry, 51, 693-707. preprint pdf
Siegle, G. J., Granholm, E., Ingram R., Matt, G. (2001). Pupillary response and reaction time measures of sustained processing of negative information in depression, Biological Psychiatry, 49, 624-636. preprint html
Siegle, G. J., Steinhauer, S. R., Carter, C., Thase, M. E. (2000). Convergence and divergence in measures of rumination. In G. Siegle and C. Papageorgiou (Chairs), Depressive rumination: Nature and Consequences. Meeting of the Association for the Advancement of Behavior Therapy, New Orleans, LA.preprint html
Siegle, G. J., Ingram, R. E., & Matt, G. E. (2002). Affective interference: Explanation for negative information processing biases in dysphoria? Cognitive Therapy and Research, 26, 73-88.preprint html
Siegle, G.J. (1999) A neural network model of attention biases in depression, in Reggia, J. and Ruppin, E. (Eds.) Disorders of brain, behavior, and cognition: The neurocomputational perspective. (pp. 415-441) New York, NY: Elsevier preprint html
Siegle, G. J. (1999).Cognitive and Physiological Aspects of Attention to Personally Relevant Negative Information in Depression, Unpublished Doctoral Dissertation, San Diego State University, University of California, San Diego.
Williams, G., Conner, J., Siegle, G. J., Ingram, R., & Cole, D. (1998). Is more negative less positive? Relating dysphoria to emotion ratings. Presentation at the meeting of the Western Psychological Association, Albuquerque, New Mexico.
Siegle, G. J. (1996). Rumination on affect: Cause for negative attention biases in depression?, Unpublished Masters Thesis, San Diego State University, San Diego, CA.
To link to more publications: click here
Here's an animation showing the mean of 25 control participants' brain activity associated with rating the personal relevance of positive words. The animation was made by generating a snapshot of regions significantly different (p<0.001) from the pre-trial baseline at each TR (1.5 seconds) for the 12 second trial (in AFNI), and interpolating between them (in Virtual Dub). As shown in the animation the anterior cingulate reacts early, followed slightly later by BA47, a brain region associated with rumination. Data from Siegle, G.J., Thompson, W., Thase, M.E., Steinhauer, S.R., Carter, C. S., (in press). Increased amygdala and decreased dorso-lateral prefrontal BOLD responses in unipolar depression: Related and independent features. Biological Psychiatry. Animation by Greg Siegle and Lena Gemmer.
Here's an animation showing the location of the amygdala. Roma Konecky and I made this from an SPGR image acquired on a 1.5T GE scanner using BrainVoyager to align and smooth the image, MRICro to trace the amygdala, AFNI to create the rendering, and WWW Gif Animator to concatenate the frames.
Here's an animation showing brain regions in which depressed participants displayed more brain activity in response to negative words than never-depressed people. I used AFNI to create the rendering and WWW Gif Animator to concatenate the frames. The data is from our paper, Siegle et al (2002) Biological Psychiatry.
Here are a few interesting mathematical functions I've been playing with lately.
