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Research - George D. Leikauf

Investigate the functional genomics of acute lung injury, asthma, chronic obstructive pulmonary disease. Molecular mechanisms by which air pollutants exacerbate or cause lung diseases are being studied by various strategies including (genetic linkage and microarray) analyses and transgenic/gene-targeted murine systems. A major research interest is uncovering the genetic basis of increased susceptibility to pulmonary epithelial injury and repair. In addition, recent studies are examining on transcriptional regulation of molecular targets (e.g. surfactant proteins) altered by exposure to ozone, aldehydes, and particulate matter.

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Current Funding:

Year	Title	Position
12/01/05-11/30/10	Growth Factor Protection in Acute Lung Injury	Principal Investigator
9/26/06-6/20/11	Functional Genomics of Chemical -Induced Acute Lung Injury	Principal Investigator
3/01/08-2/28/12	"Metalloproteinases control of Mucin expression in COPD"	Principal Investigator

Pending Funding

Year	Title	Position
12/01/10–11/30/15	"Functional genomics of genetic variants controlling lung function”	Principal Investigator