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Department of Environmental and Occupational Health

Publications - George D. Leikauf

Past 5 years

  1. McDowell S.A., Gammon K., Zingarella B., Bachruski C.J., Prows D.R., Leikauf G.D.: Inhibition of nitric oxide restores surfactant gene expression during acute lung injury. Am. J. Respir. Cell Mol. Biol. 28:188-198, 2003. PMID: 12540486


  2. Prows D.R., Mc Dowell S.A., Aronow B.J., Leikauf G.D: Genetic susceptibility to nickel-induced acute lung injury. Chemosphere 51:1139-1148, 2003. PMID: 12718980


  3. Perkowski S., Sun J., Singhal S., Santiago J., Leikauf G.D., Albelda S.M.: Gene expression profiling of the early pulmonary response to hyperoxia in mice. Am. J. Respir. Cell Mol. Biol. 28: 682-696, 2003. PMID: 12760966


  4. Leikauf G.D., Wesselkamper SC, Bachurski C., Medvedovic M., Sartor M.A., Tomlinson C.R., McDowell S.A., Case L.M., Haffey B.D., Henning L.M., Horner M.L., Hardie W.D., Korfhagen T.R, Prows D.R.: Transcriptional Regulatory Networks in Acute Lung Injury. In: Effects of Air Contaminants on the Respiratory Tract – Interpretations from Molecules to Meta Analysis. U. Heinrich (ed.), Fraunhofer IRB Verlag, Stuutgart, 373-396, 2004.


  5. Leikauf G.D., Hardie W.D., Wesselkamper S.C., Bachurski C.J., Medvedovic M., Sartor M.A., Tomlinson C.R., McDowell S.A., Henning L.M., Case L.M., Tichelaar J.W., Prows D.R., Korfhagen T.R.: Resolving Gene-Environment Interactions in Complex Traits: Acute Lung Injury. In Whitsett J.A., et al. Functional Genomics of Lung Disease. Am J. Respir. Cell Mol Biol. 31: S23-34, 2004.


  6. Deshmukh H.S., Case L.N., Wesselkamper S.C., Borchers M.T., Martin L.D., Shertzer H.G., Nadel J.A., Leikauf G.D.: Acrolein increases Mucin5AC transcripts by a ligand-dependent epidermal growth factor receptor activation mediated by metalloproteinases. Am. J. Respir. Crit. Care Med. 171:305-14, 2005. Abstract


  7. Leikauf G.D., Deshmukh, H.: When wheeze leads to squeeze: growth under pressure. Am J Respir Cell Mol Biol. 32:366, 2005. Abstract


  8. Wesselkamper S.C., Case L.M., Henning L. M., Borchers M. J., Tichelaar J.W., Medvedovic M., Sartor M. A., Tomlinson C.R, Leikauf G.D.: Gene Expression Changes During Acute Lung Injury: Role of Transforming Growth Factor- b. Am J Respir Crit Care Med 172:1399-411, 2005. PMID: 16100012


  9. Tichelaar J.W., Leikauf G. D. Lung Cancer (Chapter 15). In Molecular Carcinogenesis and Molecular Biology of Human Cancer. Warshawsky D and Landolph J (ed) Taylor & Francis, LLC,. 2005.


  10. Mallakin A, Kutcher L.W., McDowell S.A., Kong S., Schuster R., Lentsch A.B., Aronow B.J., Leikauf G.D., Waltz S.E.: Gene expression profiles of Mst1r deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol 34: 15-28, 2006. PMID: 16166746


  11. Wesselkamper S.C., McDowell S.A., Medvedovic M., Dalton T.P., Deshmukh H.S., Sartor M.A., Case L.M., Henning L.N., Borchers M.T., Tomlinson C.R., Prows D.R., Leikauf G.D.: The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol 34: 73-82, 2006. PMID: 16166738


  12. Sartor M.A, Tomlinson C.R., Wesselkamper S.C., Sivaganesan S., Leikauf G.D., Medvedovic M. Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments. BMC Bioinformatics. 7:538-54, 2006. PMID: 17177995


  13. Hardie W. D., Korfhagen T. R., Sartor M.A., Prestridge A., Medvedovic M., Le Cras T.D., Ikegami M., Tomlinson C.R., Nichols W., Dietsch M.A., Wesselkamper S.C., Whitsett J.A. Leikauf G.D. Genomic Profile of Matrix and Vasculature Remodeling in TGF alpha -induced Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Biol. 2007 May 11; PMID: 17496152


  14. Raj J.; Aliferis C.; Caprioli R., Cowley Jr A., Davies P., Duncan M., Erle D., Erzurum S.C., Finn P., Ischiropoulos H., Kaminski N., Kleeberger S., Leikauf G., Loyd J., Martin T., Matalon S., Moore J., Quackenbush J. Sabo-Attwood T., Shapiro S., Schnitzer J., Schwartz D., Schwiebert L., Wurfel, M., Weiss S., Ware L., Sheppard D., Matthay M.,Whitsett J. Genomics and Proteomics of Lung Disease. Am J Physiol: Lung Cell Mol. Physiol. 293:L45-51, 2007. PMID: 17468134


  15. Prows DR, Hafertepen AP, Winterberg AV, Gibbons Jr WJ, Wesselkamper SC, Singer JB, Hill AE, Nadeau JH, Leikauf GD. Reciprocal Congenic Lines of Mice Capture the Aliq1 Effect on Acute Lung Injury Survival Time.Am J Respir Cell Mol Biol. 2007 Jul 26; PMID: 17656683


  16. Ganguly K, Stoeger T., Wesselkamper S.C. Reinhard C., Sartor M.A., Medvedovic A., Tomlinson C.R., Bolle I., Mason J.M., Leikauf G.D., Schulz H. Candidate genes controlling pulmonary function: transcript profiling and predicted protein structure. Physiol Genomics. 2007 Sep 5; PMID: 17804602


  17. Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD. CD8(+) T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol. 2007 Sep 26; [Epub ahead of print]. PMID: 17950725


  18. Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, Whitsett JA. Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 2007 Oct;33(8):385-417. PMID: 17994369


  19. Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production. Am J Respir Cell Mol Biol. 2007 Nov 15; [Epub ahead of print]. PMID: 18006877


  20. Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr; 38 ( 4 ): 446-54 . Epub 2007 Nov 15. PMID: 18006877


  21. Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR.  EGFR- tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis.  Am J Physiol Lung Cell Mol Physiol. 2008 Apr 18; PMID: 18424623


  22. Mongan M, Tan Z, Chen L, Peng Z, Dietsch M, Su B, Leikauf G, Xia Y.  Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury.  Toxicol Sci. 2008 May 7. [Epub ahead of print]  PMID: 18467339

Submitted

  1. Leikauf, G.D.: Formaldehyde and other aldehydes. In: Environmental Toxicants: Human Exposures and Their Health Effects. (3ed) M. Lippmann, ed., Van Nostrand Reinhold, New York, NY (In Press)


  2. Lippmann M, Leikauf G.D. Introduction and Background. In: Environmental Toxicants: Human Exposures and Their Health Effects. (3ed) M. Lippmann, ed., Van Nostrand Reinhold, New York, NY (In Press)


  3. Deshmukh H.S., McLachlan A., Shaver C., Case L.M., Wesselkamper S.C., Korfhagen T.R., Hardie W.D., Dietsch M. A., Corradi M., Nadel J.A., Borchers M.T., Leikauf G.D.: Acrolein-activated matrix metallo-proteinase 9 leads to persistent mucin production. Am J Respir Cell Mol Biol. (In Revision)


  4. Sartor M.A., Leikauf G.D. Medvedovic M.: Systematic comparisons reveal that logistic regression provides a simple yet powerful approach to identifying enriched biological groups in gene expression data. Genome Biology (Submitted)


  5. Tichlear J.W,. Wesselkamper S.C., Chowdhury S., Yin H., Berclaz P.V., Sartor M.A., Leikauf G.D., Whitsett J.A. Duration-dependent cytoprotective versus inflammatory effects of lung epithelial FGF7 expression. Am J Respir Cell Mol Biol (Submitted)